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53/100

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

The correlation between white and gray matter disappeared after partial-volume correction in 11 C-PIB ( r 2 = 0) but persisted for 18 F-flortaucipir ( r 2 = 0.27), demonstrating that the correlation between white and gray matter signal in 18 F-flortaucipir is not solely due to partial-volume effects. A linear regression showed that off-target signal from putamen and thalamus together explained 64% of the variability in the cortical signal in amyloid-negative HCs (not seen in amyloid-positive HCs). Variability in amyloid-negative HCs but not amyloid-positive HCs correlated with white matter signal (unrelated to partial-volume effects) and age-related off-target signal (possibly related to iron load). The noise in the 18 F-flortaucipir measurement could pose challenges when studying early tau accumulation.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Baker, S. L., Harrison, T. M., Maass, A., La Joie, R., & Jagust, W. J. (2019). Effect of Off-Target Binding on 18F-Flortaucipir Variability in Healthy Controls Across the Life Span. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.118.224113

Vancouver

Baker SL, Harrison TM, Maass A, La Joie R, Jagust WJ. Effect of Off-Target Binding on 18F-Flortaucipir Variability in Healthy Controls Across the Life Span. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019. doi:10.2967/jnumed.118.224113. PMID: 30877180.

BibTeX

@article{baker2019-30877180,
  author  = {Baker, S. L. and Harrison, T. M. and Maass, A. and La Joie, R. and Jagust, W. J.},
  title   = {{Effect of Off-Target Binding on 18F-Flortaucipir Variability in Healthy Controls Across the Life Span}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2019},
  doi     = {10.2967/jnumed.118.224113},
  pmid    = {30877180},
  url     = {https://doi.org/10.2967/jnumed.118.224113}
}

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Key findings

The correlation between white and gray matter disappeared after partial-volume correction in 11 C-PIB ( r 2 = 0) but persisted for 18 F-flortaucipir ( r 2 = 0.27), demonstrating that the correlation between white and gray matter signal in 18 F-flortaucipir is not solely due to partial-volume effects.
A linear regression showed that off-target signal from putamen and thalamus together explained 64% of the variability in the cortical signal in amyloid-negative HCs (not seen in amyloid-positive HCs).
Variability in amyloid-negative HCs but not amyloid-positive HCs correlated with white matter signal (unrelated to partial-volume effects) and age-related off-target signal (possibly related to iron load).
The noise in the 18 F-flortaucipir measurement could pose challenges when studying early tau accumulation.

Why it matters

This analysis found that off-target signal from the putamen and thalamus explained much of the variability in cortical flortaucipir signal in amyloid-negative healthy controls, and that this variability correlated with white matter signal and age-related off-target signal. The authors note this noise could pose challenges when studying early tau accumulation.

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Study details

Participants139
Evidence strengthLow

How this study scored 53/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
Journal's citation record	2 / 4	Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2019 — within 10 year(s) of the newest study here
Sample size	2 / 4	139 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 131 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	14.6 citations a year over 9 year(s) since 2019
Impact for its field and year	4 / 6	Cited 11.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 7 other studies in this library
Still being cited	2 / 4	Cited 49 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author William J. Jagust: h-index 152 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, Berkeley: institution h-index 2,012 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30877180)
Free to read	0 / 2	Behind a paywall — scores zero
Total	53 / 100	—

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