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Anterior insula degeneration in frontotemporal dementia
Seeley WW.. Brain structure & function, 2010-05-29
Topic: Risk, prevention and care in population studies
The human anterior insula is anatomically and functionally heterogeneous, containing key nodes within distributed speech-language and viscero-autonomic/social-emotional networks. The frontotemporal dementias selectively target these large-scale systems, leading to at least three distinct clinical syndromes. Examining these disorders, researchers have begun to dissect functions which rely on specific insular nodes and networks. In the behavioral variant of frontotemporal dementia, early-stage frontoinsular degeneration begets progressive "Salience Network" breakdown that leaves patients unable to model the emotional impact of their own actions or inactions. Ongoing studies seek to clarify local microcircuit- and cellular-level factors that confer selective frontoinsular vulnerability. The search for frontotemporal dementia treatments will depend on a rich understanding of insular biology and could help clarify specialized human language, social, and emotional functions.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Seeley, W. W. (2010). Anterior insula degeneration in frontotemporal dementia. Brain structure & function. https://doi.org/10.1007/s00429-010-0263-z
Vancouver
Seeley WW. Anterior insula degeneration in frontotemporal dementia. Brain structure & function. 2010. doi:10.1007/s00429-010-0263-z. PMID: 20512369.
BibTeX
@article{seeley2010-20512369,
author = {Seeley, W. W.},
title = {{Anterior insula degeneration in frontotemporal dementia}},
journal = {Brain structure \& function},
year = {2010},
doi = {10.1007/s00429-010-0263-z},
pmid = {20512369},
url = {https://doi.org/10.1007/s00429-010-0263-z}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The frontotemporal dementias selectively target these large-scale systems, leading to at least three distinct clinical syndromes.
- Examining these disorders, researchers have begun to dissect functions which rely on specific insular nodes and networks.
- In the behavioral variant of frontotemporal dementia, early-stage frontoinsular degeneration begets progressive "Salience Network" breakdown that leaves patients unable to model the emotional impact of their own actions or inactions.
- Ongoing studies seek to clarify local microcircuit- and cellular-level factors that confer selective frontoinsular vulnerability.
- The search for frontotemporal dementia treatments will depend on a rich understanding of insular biology and could help clarify specialized human language, social, and emotional functions.
Why it matters
This paper describes how frontotemporal dementias damage the anterior insula and related brain networks, leading to problems with social and emotional functions. It is about understanding these diseases and states that the search for treatments will depend on better understanding insular biology.
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Study details
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain structure & function) |
| Journal's citation record | 1 / 4 | Brain Structure and Function: journal h-index 131 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 161 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.9 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 4 / 6 | Cited 9.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 18 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author William W. Seeley: h-index 126 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20512369) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
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Read the original
- DOI: 10.1007/s00429-010-0263-z
- PubMed: 20512369
- Original source →
- Free full text: Brain Structure and Function →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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