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Inflammatory Alterations and Multidomain Cognition in Alzheimer Disease and Related Dementias
Anna P. Smith, Diana Guzman, Seonjoo Lee, Daniel Talmasov, Dina Dass, Ndubisi Chikwem, Aubrey S. Johnson, Hannah M. Houlihan et al.. Alzheimer Disease & Associated Disorders, 2025-10-01
Topic: Amyloid, tau and blood-test diagnosis
Greater TSPO is associated with lower performance in episodic memory, attention/processing speed, executive function, language, and visuospatial ability in amyloid-positive individuals, but restricted to episodic memory in amyloid-negative individuals. Targeting microglia as an additional or alternative strategy for cognitive impairment in Alzheimer disease and related dementias may provide further benefits, even in amyloid-negative individuals.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Smith, A. P., Guzman, D., Lee, S., Talmasov, D., Dass, D., Chikwem, N., et al. (2025). Inflammatory Alterations and Multidomain Cognition in Alzheimer Disease and Related Dementias. Alzheimer Disease & Associated Disorders. https://doi.org/10.1097/wad.0000000000000706
Vancouver
Smith AP, Guzman D, Lee S, Talmasov D, Dass D, Chikwem N, et al. Inflammatory Alterations and Multidomain Cognition in Alzheimer Disease and Related Dementias. Alzheimer Disease & Associated Disorders. 2025. doi:10.1097/wad.0000000000000706. PMID: 41288277.
BibTeX
@article{smith2025-41288277,
author = {Smith, Anna P. and Guzman, Diana and Lee, Seonjoo and Talmasov, Daniel and Dass, Dina and Chikwem, Ndubisi and Johnson, Aubrey S. and Houlihan, Hannah M. and others},
title = {{Inflammatory Alterations and Multidomain Cognition in Alzheimer Disease and Related Dementias}},
journal = {Alzheimer Disease \& Associated Disorders},
year = {2025},
doi = {10.1097/wad.0000000000000706},
pmid = {41288277},
url = {https://doi.org/10.1097/wad.0000000000000706}
}
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Key findings
- Greater TSPO is associated with lower performance in episodic memory, attention/processing speed, executive function, language, and visuospatial ability in amyloid-positive individuals, but restricted to episodic memory in amyloid-negative individuals.
- Targeting microglia as an additional or alternative strategy for cognitive impairment in Alzheimer disease and related dementias may provide further benefits, even in amyloid-negative individuals.
Why it matters
Greater TSPO, a marker of microglial activation, was linked to lower performance across several cognitive domains in amyloid-positive individuals, but only to episodic memory in amyloid-negative individuals. The authors suggest targeting microglia may provide further benefits, but this cross-sectional finding is not itself a treatment or cure.
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Study details
- Study designcross-sectional
- Participants21
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer Disease & Associated Disorders) |
| Journal's citation record | 1 / 4 | Alzheimer Disease & Associated Disorders: journal h-index 131 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 21 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 1 / 6 | Cited 0.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Patrick J. Lao: h-index 28 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Columbia University: institution h-index 1,824 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41288277) |
| Free to read | 2 / 2 | Free to read |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1097/wad.0000000000000706
- PubMed: 41288277
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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