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Research

27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 1–25 of 29 studies by Koudstaal PJ (page 1 of 2) · 27,380 in the whole library · How the 0–100 score works

Showing 29 studies tagged prospective — clear

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Other authors

Names as each record prints them; the same person can appear under two spellings.

Institutions

From OpenAlex; 12,859 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study

✓ Peer-reviewed alzhub usefulness score 69 out of 100. Neurology 2012-05-02

In the 1990 subcohort (25,696 person-years), 286 persons developed dementia, and in the 2000 subcohort (8,384 person-years), 49 persons. 4 key findings →

Design: cohort study Participants: 5,727 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study

✓ Peer-reviewed alzhub usefulness score 67 out of 100. The Lancet. Neurology 2006-08-01

High concentrations of Abeta(1-40) but not Abeta(1-42) at baseline were associated with an increased risk of dementia. 5 key findings →

Design: cohort study Participants: 6,713 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Cerebral Perfusion and the Risk of Dementia: A Population-Based Study

✓ Peer-reviewed alzhub usefulness score 67 out of 100. Circulation 2017-06-06

Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether hypoperfusion precedes neurodegeneration is unknown. 4 key findings →

Design: cross-sectional Participants: 4,759 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Association Between Atrial Fibrillation and Dementia in the General Population

✓ Peer-reviewed alzhub usefulness score 65 out of 100. JAMA neurology 2015-11-01

Atrial fibrillation (AF) has been suggested as a risk factor for dementia since it may lead to chronic cerebral hypoperfusion and stroke. 4 key findings →

Design: longitudinal study Participants: 6,514 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study

✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2005-06-01

Unsaturated fatty acids are important constituents of neuronal cell membranes and have neuroprotective, antioxidant, and anti-inflammatory properties. 4 key findings →

Design: cohort study Participants: 5,289 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Subjective memory complaints, education, and risk of Alzheimer's disease

✓ Peer-reviewed alzhub usefulness score 61 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2007-03-23

Although memory complaints are associated with an increased risk of Alzheimer's disease in persons with cognitive impairment as well as in persons with normal cognition, they are commonly considered of less importance than objective cognitive measures. 4 key findings →

Design: cohort study Participants: 7,983 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Retinopathy and risk of dementia: the Rotterdam Study

✓ Peer-reviewed alzhub usefulness score 58 out of 100. Neurology 2012-07-11

We investigated the associations between retinopathy and dementia and its subtypes Alzheimer disease (AD) and vascular dementia both cross-sectionally and prospectively in the Rotterdam Study, a large population-based cohort study. 4 key findings →

Design: cohort study Participants: 195 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Cerebral Vasoreactivity, Apolipoprotein E, and the Risk of Dementia: A Population-Based Study

✓ Peer-reviewed alzhub usefulness score 58 out of 100. Arteriosclerosis, thrombosis, and vascular biology 2015-11-19

Cerebral vasoreactivity (CVR) is a key factor in maintenance of continuous cerebral perfusion and a marker of (micro)vascular damage. 4 key findings →

Design: longitudinal study Participants: 1,629 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

10-year trajectories of depressive symptoms and risk of dementia: a population-based study

✓ Peer-reviewed alzhub usefulness score 55 out of 100. The lancet. Psychiatry 2016-04-29

Late-life depressive symptoms have been extensively studied for their relationship with incident dementia, but have been typically assessed at a single timepoint. 4 key findings →

Participants: 3,325 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

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Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed