{ "generated": "2026-09-29", "methodology": "Every number in this file was counted directly from data/research.json (17,989 records), data/research_score.json (alzhub's own scoring rubric, computed by research_score.py from the same research.json), and data/most_cited.json (an independent RCR/citation-count file covering 7,080 records, built separately from iCite/OpenAlex/Semantic Scholar — it does NOT cover every record in research.json and predates the 2026-09-28 merge that grew the library from 10,098 to 17,989). Nothing here is estimated, interpolated, or carried over from a prior report. The measuring script is scripts/build_library_gaps.py; run it after any change to research.json to keep this file honest.", "scope_note": "This measures alzhub.org's own research library (data/research.json, 17,989 records). It has nothing to do with DivertGuard's 723 documented cases, which is a separate product. Site-wide background statistics (e.g. 7.2M Americans living with Alzheimer's, 33.4% prevalence at 85+, $405,262 lifetime care cost) are not library coverage metrics and are not re-measured here.", "n_total_records": 17989, "n_total_records_previous_report": 10098, "corpus_growth_note": "The library grew from 10,098 to 17,989 records on 2026-09-28 (7,891 new records added). All 7,891 new records came from OpenAlex, PubMed, medRxiv and Crossref; the pre-existing 9,734 Europe PMC records and 269 legacy-curated records are unchanged. Any coverage claim made about the 10,098-record corpus no longer describes this library.", "record_provenance": { "legacy_curated_batch": 269, "automated_fetch_pipeline_batch": 17625, "unmarked_batch": 95, "note": "research.json mixes three distinct generations of records with different schemas. 269 carry legacy fields (pubmed_id, publication_type, peer_reviewed, source_wave, retrieved) from hand-curated batches. 17625 carry the automated pipeline's fields (open_access, abstract_available, source, pub_types) written by fetch_research.py. The remaining 95 carry neither marker." }, "source_composition": { "note": "Per-source breakdown of the automated_fetch_pipeline_batch only (the legacy_curated_batch and unmarked_batch carry no `source` field). Shares are of the full 17,989-record corpus.", "counts": { "Europe PMC": 12591, "OpenAlex": 4625, "medRxiv": 135, "PubMed": 165, "Crossref": 109 }, "pct_of_corpus": { "Europe PMC": 70.0, "OpenAlex": 25.7, "medRxiv": 0.8, "PubMed": 0.9, "Crossref": 0.6 }, "pct_europe_pmc_alone": 70.0, "pct_medrxiv_alone": 0.8 }, "peer_review_and_preprint_status": { "note": "Two independent ways to identify a preprint, reported side by side because they do not fully agree. (a) `source`==\"medRxiv\": every medRxiv-sourced record is a preprint by construction. (b) any pub_types tag of preprint/Preprint/posted-content: broader, because it also catches preprints indexed via Europe PMC or Crossref. (c) the site's own scoring rubric (research_score.py classify_status), which reads the journal/URL string and is what actually drives the peer-review cap shown to readers.", "medrxiv_sourced_count": 135, "pub_types_preprint_tagged_count": 213, "pub_types_preprint_tagged_by_source": { "Europe PMC": 47, "medRxiv": 135, "Crossref": 31 }, "pub_types_preprint_tagged_rubric_status": { "preprint": 177, "peer-reviewed": 36 }, "rubric_status_counts": { "peer-reviewed": 17757, "regulatory": 9, "press-release": 3, "report": 19, "abstract": 4, "retracted": 17, "preprint": 180 }, "rubric_peer_reviewed_count": 17757, "rubric_not_peer_reviewed_count": 232, "pct_not_peer_reviewed": 1.3 }, "year_coverage": { "records_with_year": 17985, "records_without_year": 4, "min_year": 1932, "max_year": 2026, "histogram": { "1932": 1, "1935": 1, "1958": 1, "1960": 1, "1963": 1, "1967": 1, "1968": 1, "1969": 1, "1970": 1, "1975": 3, "1976": 2, "1977": 4, "1978": 1, "1979": 2, "1980": 6, "1981": 2, "1982": 13, "1983": 10, "1984": 12, "1985": 16, "1986": 22, "1987": 23, "1988": 47, "1989": 40, "1990": 66, "1991": 49, "1992": 65, "1993": 79, "1994": 88, "1995": 97, "1996": 125, "1997": 162, "1998": 152, "1999": 172, "2000": 219, "2001": 230, "2002": 263, "2003": 252, "2004": 316, "2005": 334, "2006": 401, "2007": 376, "2008": 423, "2009": 456, "2010": 531, "2011": 491, "2012": 539, "2013": 591, "2014": 548, "2015": 608, "2016": 591, "2017": 655, "2018": 682, "2019": 706, "2020": 737, "2021": 683, "2022": 615, "2023": 508, "2024": 513, "2025": 3280, "2026": 1170 }, "year_bands": { "before_1990": 212, "1990_1999": 1055, "2000_2009": 3270, "2010_2019": 5942, "2020_present": 7506 }, "reference_year": 2026, "pct_within_5y_of_reference": 37.6, "pct_within_10y_of_reference": 56.4, "n_before_2000": 1267 }, "identifier_coverage": { "has_doi": 17732, "has_pmid": 16764, "has_both": 16603, "has_either": 17893, "has_neither": 96 }, "author_coverage": { "records_with_no_authors_field_or_empty": 37, "records_with_exactly_one_name_listed": 707, "records_whose_author_string_contains_et_al": 6660, "median_authors_listed": 7.0, "mean_authors_listed": 6.1 }, "category_distribution": { "risk_factors": 979, "prevention": 872, "treatments": 809, "genetics": 802, "biomarkers": 796, "diagnosis": 781, "digital": 739, "end_of_life": 698, "disparities": 689, "caregiving": 677, "mci": 667, "mechanisms": 666, "prevention_trials": 662, "inflammation": 659, "genetics_genes": 630, "imaging": 624, "genetics_trem2": 580, "clinical_safety": 569, "assessment": 560, "lewy_body": 543, "down_syndrome": 538, "cohorts": 512, "epidemiology": 493, "imaging_hippocampus": 492, "health_systems": 477, "neuropathology": 447, "biomarkers_tau": 447, "vascular": 379, "drug_development": 94, "basic-science": 46, "health-economics": 40, "clinical-trial": 22 }, "study_design_distribution": { "(none)": 12868, "longitudinal study": 1116, "cohort study": 1008, "cross-sectional": 956, "meta-analysis": 471, "systematic review": 419, "randomized controlled trial": 361, "case-control study": 167, "clinical trial": 134, "cohort": 133, "narrative review": 68, "prospective cohort": 51, "RCT": 40, "open-label trial": 40, "post-hoc analysis": 29, "retrospective cohort": 27, "modelling": 20, "case report": 17, "case-control": 16, "phase-3-trial": 14, "systematic-review": 11, "phase-2-trial": 10, "regulatory decision": 6, "umbrella review": 3, "phase-1-trial": 2, "company announcement": 1, "coverage determination": 1 }, "summary_and_abstract_provenance": { "confirmed_abstract_derived_by_pipeline_field": 17486, "provenance_not_recorded_in_file": 364, "note": "research.json stores no raw abstract text field at all (only derived summary/key_findings). abstract_available=True is present only on records built by the automated fetch_research.py pipeline. For the remaining records (the legacy pubmed_id batch and the unmarked batch) research.json contains no field stating whether the summary text came from an abstract, so that provenance cannot be measured from this file and is reported as not recorded rather than assumed either way." }, "field_completeness": { "empty_key_findings": 235, "empty_why_it_matters": 2727, "empty_limitations": 17589, "pct_empty_why_it_matters": 15.2, "pct_empty_limitations": 97.8, "note_why_it_matters_and_limitations": "templates/study.html, research.html, caregiving.html and prevention.html all render these fields conditionally ({% if %}) and simply omit the section when empty, rather than showing a placeholder. So this is a real, user-visible gap: on the great majority of study pages, a reader sees no \"why it matters\" note and no stated limitations at all.", "no_study_design_recorded_blank": 12868, "study_design_present_but_unmapped_by_rubric": { "regulatory decision": 6, "company announcement": 1, "clinical trial": 134, "coverage determination": 1, "phase-1-trial": 2, "case report": 17, "open-label trial": 40, "post-hoc analysis": 29, "narrative review": 68, "umbrella review": 3 }, "study_design_present_and_mapped_by_rubric": 4820, "no_n_participants": 11120, "no_effect_size": 14299, "neither_n_participants_nor_effect_size": 9957, "evidence_strength_distribution": { "low": 11665, "moderate": 3793, "high": 2187, "early": 49, "null-result": 23, "preliminary": 15 }, "pct_evidence_strength_low": 64.8 }, "peer_review_screen": { "rubric_version": "4.0", "peer_review_cap": 16, "status_counts": { "peer-reviewed": 17757, "regulatory": 9, "press-release": 3, "report": 19, "abstract": 4, "retracted": 17, "preprint": 180 }, "peer_reviewed_count": 17757, "not_peer_reviewed_count": 232, "pct_not_peer_reviewed": 1.3, "capped_at_peer_review_cap_count": 210, "score_min": 9, "score_median": 49, "score_max": 88, "records_missing_component": { "Randomised / blinded": 15620, "Journal's citation record": 3340, "Times cited": 2989, "Citations per year": 2993, "Impact for its field and year": 3245, "Still being cited": 2989, "Senior author's track record": 4530, "Institution's track record": 3392, "Multi-centre collaboration": 2851, "Indexed in PubMed": 96, "Free to read": 364, "Study design": 12402, "Sample size": 11120, "Effect reported": 14299, "Studied in people": 9790, "Strength of evidence": 257, "Cited by studies here": 2740, "How recent": 4, "Journal tier": 2 }, "peer_reviewed_score_range": { "min": 21, "max": 88, "median": 49 }, "not_peer_reviewed_score_range": { "min": 9, "max": 16 } }, "topicality_spot_check": { "method": "Regex search for alzheimer|dementia|cognit|amyloid|\\btau\\b|neurodegenerat|\\bmci\\b|memory (loss|impair)|neuropatholog|apoe|trem2 (case-insensitive) against each record's title + summary combined. A record that matches nothing is flagged, not judged off-topic — most flagged records are legitimate Alzheimer's-adjacent research (risk-factor, health-systems or caregiving studies that don't happen to use these words), but a manual look at a sample of the flagged set also found records with no connection to Alzheimer's or dementia at all.", "n_no_keyword_match": 1090, "pct_of_corpus": 6.1, "by_source": { "legacy/unmarked": 3, "Europe PMC": 600, "OpenAlex": 396, "medRxiv": 4, "PubMed": 6, "Crossref": 81 }, "by_category_top10": { "imaging_hippocampus": 246, "prevention": 144, "risk_factors": 123, "health_systems": 87, "genetics_trem2": 69, "lewy_body": 62, "inflammation": 42, "cohorts": 32, "assessment": 31, "neuropathology": 30 }, "confirmed_off_topic_examples": [ { "title": "Systemic Blastomycosis, with Report of a Fatal Case", "year": 1932, "source": "OpenAlex", "doi": "10.1148/18.2.305" }, { "title": "CHEMICAL WARFARE AND THE DOCTOR--II", "year": 1939, "source": "OpenAlex", "doi": "10.1136/bmj.2.4110.778" }, { "title": "Grocery lists: connecting family, household and grocery store", "source": "Crossref" }, { "title": "Be a Super Shopper!", "source": "Crossref" } ], "caveat": "This is a lower-bound signal from a crude heuristic, not an audited contamination count. The confirmed examples above were checked by hand; the remaining 1,086 keyword-flagged records have not been individually reviewed and most are presumed genuinely on-topic." }, "top20_most_influential_by_rcr": { "source": "data/most_cited.json, scopes.all.by_rcr, sorted descending, top 20 taken", "cross_checked_against": "data/research.json (17,989 records; matched by pmid, then doi, then normalised title)", "caveat": "data/most_cited.json covers 7,080 of this library's 17,989 records and was built on 2026-09-27, before the 2026-09-28 merge added 4,681 new records. None of the new records have a citation count in this site's data, so this top-20 list cannot surface a highly-cited paper among them even if one exists. This is a known, stated gap, not a claim that these 20 are the most-cited studies in the full library.", "summary": { "n_found_in_research_json": 20, "n_missing_from_research_json": 0 }, "studies": [ { "title": "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease", "year": 1984, "journal": "Neurology", "pmid": "6610841", "doi": "10.1212/wnl.34.7.939", "rcr": 819.8800042542669, "in_research_json": true, "match_method": "pmid", "category": "diagnosis", "research_score": 58, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission.", "year": 2024, "journal": "The Lancet", "pmid": "39096926", "doi": "10.1016/s0140-6736(24)01296-0", "rcr": 722.0266293189633, "in_research_json": true, "match_method": "title", "category": "prevention", "research_score": 66, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": true, "has_study_design": true, "has_n_participants": false, "has_effect_size": true, "has_doi": false, "has_pmid": false } }, { "title": "Lecanemab in Early Alzheimer's Disease.", "year": 2023, "journal": "New England Journal of Medicine", "pmid": "36449413", "doi": "10.1056/nejmoa2212948", "rcr": 618.6061153547586, "in_research_json": true, "match_method": "pmid", "category": "treatments", "research_score": 81, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": true, "has_n_participants": true, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment", "year": 2005, "journal": "Journal of the American Geriatrics Society", "pmid": "15817019", "doi": "10.1111/j.1532-5415.2005.53221.x", "rcr": 606.7980439297423, "in_research_json": true, "match_method": "pmid", "category": "diagnosis", "research_score": 60, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": true, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.", "year": 2024, "journal": "Alzheimer's & Dementia", "pmid": "38934362", "doi": "10.1002/alz.13859", "rcr": 476.2471784788035, "in_research_json": true, "match_method": "title", "category": "diagnosis", "research_score": 42, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": true, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": false, "has_pmid": false } }, { "title": "Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019.", "year": 2022, "journal": "The Lancet Public Health", "pmid": "34998485", "doi": "10.1016/s2468-2667(21)00249-8", "rcr": 472.8487891753635, "in_research_json": true, "match_method": "pmid", "category": "caregiving", "research_score": 63, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "2024 Alzheimer's disease facts and figures", "year": 2024, "journal": "Alzheimer's & dementia : the journal of the Alzheimer's Association", "pmid": "38689398", "doi": "10.1002/alz.13809", "rcr": 454.856242797623, "in_research_json": true, "match_method": "pmid", "category": "caregiving", "research_score": 62, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": false, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease", "year": 2011, "journal": "Alzheimer's & dementia : the journal of the Alzheimer's Association", "pmid": "21514250", "doi": "10.1016/j.jalz.2011.03.005", "rcr": 414.954330468547, "in_research_json": true, "match_method": "pmid", "category": "diagnosis", "research_score": 61, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.", "year": 2018, "journal": "Alzheimer's & Dementia", "pmid": "29653606", "doi": "10.1016/j.jalz.2018.02.018", "rcr": 409.10096046325356, "in_research_json": true, "match_method": "pmid", "category": "diagnosis", "research_score": 64, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "2023 Alzheimer's disease facts and figures", "year": 2023, "journal": "Alzheimer's & dementia : the journal of the Alzheimer's Association", "pmid": "36918389", "doi": "10.1002/alz.13016", "rcr": 390.35870139608517, "in_research_json": true, "match_method": "pmid", "category": "caregiving", "research_score": 54, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": false, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Alzheimer's disease", "year": 2021, "journal": "Lancet (London, England)", "pmid": "33667416", "doi": "10.1016/s0140-6736(20)32205-4", "rcr": 307.9938958081695, "in_research_json": true, "match_method": "pmid", "category": "prevention", "research_score": 65, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.", "year": 2023, "journal": "JAMA", "pmid": "37459141", "doi": "10.1001/jama.2023.13239", "rcr": 307.02161579416907, "in_research_json": true, "match_method": "pmid", "category": "treatments", "research_score": 75, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": true, "has_n_participants": true, "has_effect_size": true, "has_doi": true, "has_pmid": true } }, { "title": "The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia", "year": 1994, "journal": "Neurology", "pmid": "7991117", "doi": "10.1212/wnl.44.12.2308", "rcr": 232.02195372435634, "in_research_json": true, "match_method": "pmid", "category": "caregiving", "research_score": 58, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "6-month consequences of COVID-19 in patients discharged from hospital: a cohort study", "year": 2021, "journal": "Lancet (London, England)", "pmid": "33428867", "doi": "10.1016/s0140-6736(20)32656-8", "rcr": 218.44707189237684, "in_research_json": true, "match_method": "pmid", "category": "epidemiology", "research_score": 74, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": true, "has_n_participants": true, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Mild cognitive impairment: clinical characterization and outcome", "year": 1999, "journal": "Archives of neurology", "pmid": "10190820", "doi": "10.1001/archneur.56.3.303", "rcr": 217.6576993160053, "in_research_json": true, "match_method": "pmid", "category": "epidemiology", "research_score": 70, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": true, "has_n_participants": true, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Obesity: global epidemiology and pathogenesis", "year": 2019, "journal": "Nature reviews. Endocrinology", "pmid": "30814686", "doi": "10.1038/s41574-019-0176-8", "rcr": 196.1036578417428, "in_research_json": true, "match_method": "pmid", "category": "prevention", "research_score": 53, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "2022 Alzheimer's disease facts and figures", "year": 2022, "journal": "Alzheimer's & dementia : the journal of the Alzheimer's Association", "pmid": "35289055", "doi": "10.1002/alz.12638", "rcr": 183.581366448053, "in_research_json": true, "match_method": "pmid", "category": "diagnosis", "research_score": 57, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": false, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease", "year": 2011, "journal": "Alzheimer's & dementia : the journal of the Alzheimer's Association", "pmid": "21514248", "doi": "10.1016/j.jalz.2011.03.003", "rcr": 181.6293584474787, "in_research_json": true, "match_method": "pmid", "category": "diagnosis", "research_score": 70, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": true, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Mild cognitive impairment as a diagnostic entity", "year": 2004, "journal": "Journal of internal medicine", "pmid": "15324362", "doi": "10.1111/j.1365-2796.2004.01388.x", "rcr": 177.34228144564307, "in_research_json": true, "match_method": "pmid", "category": "diagnosis", "research_score": 57, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } }, { "title": "Bioaccumulation of microplastics in decedent human brains", "year": 2025, "journal": "Nature medicine", "pmid": "39901044", "doi": "10.1038/s41591-024-03453-1", "rcr": 174.8192802716375, "in_research_json": true, "match_method": "pmid", "category": "diagnosis", "research_score": 65, "peer_review_status": "peer-reviewed", "fully_populated": { "has_summary": true, "has_authors": true, "has_key_findings": true, "has_limitations": false, "has_study_design": false, "has_n_participants": false, "has_effect_size": false, "has_doi": true, "has_pmid": true } } ] } }