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50/100

✓ Peer-reviewed alzhub usefulness score 50 out of 100. TREM2 and immune genetics

Topic: Amyloid, tau and blood-test diagnosis

Background Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer's disease (AD), an expanding research body has delved into the intricate role of TREM2 within the AD context. However, a conflicting landscape of outcomes has emerged from both in vivo and in vitro investigations. This study aimed to elucidate the multifaceted nuances and gain a clearer comprehension of the role of TREM2. Methods PubMed database was searched spanning from its inception to January 2022. The search criteria took the form of ("Alzheimer's disease" OR "AD") AND ("transgenic mice model" OR "transgenic mouse model") AND ("Triggering receptor expressed on myeloid cells" OR "TREM2"). Inclusion criteria consisted of the following: (1) publication of original studies in English; (2) utilization of transgenic mouse models for AD research; and (3) reports addressing the subject of TREM2. Results A total of 43 eligible articles were identified. Our analysis addresses four pivotal queries concerning the interrelation of TREM2 with microglial function, Aβ accumulation, tau pathology, and inflammatory processes. However, the diverse inquiries posed yielded inconsistent responses. Nevertheless, the inconsistent roles of TREM2 within these AD mouse models potentially hinge upon factors such as age, sex, brain region, model type, and detection methodologies. Conclusions This review substantiates the evolving understanding of TREM2's disease progression-dependent impacts. Furthermore, it reviews the interplay between TREM2 and its effects across diverse tissues and temporal stages.

Key findings

Results A total of 43 eligible articles were identified.

Why it matters

This systematic review gathered 43 studies of TREM2, an immune receptor on microglia, in mouse models of Alzheimer's. Results on how TREM2 affects microglia, amyloid, tau and inflammation were inconsistent, possibly depending on age, sex, brain region, model type and lab methods. The authors conclude TREM2's effects likely change with disease stage, which matters for anyone hoping to target it as a treatment.

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Study details

Study designsystematic review
Participants43
Evidence strengthLow

How this study scored 50/100

Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for effect reported because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Chinese medical journal)
Journal's citation record	1 / 4	Chinese Medical Journal: journal h-index 94 (OpenAlex, 2026-10-29)
Study design	12 / 12	A systematic review of all the studies on the question
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	1 / 4	43 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	A review of other studies — randomisation is not credited here
Times cited	2 / 7	Cited 8 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.0 citations a year over 4 year(s) since 2024
Impact for its field and year	1 / 6	Cited 0.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Yi Tang: h-index 8 (OpenAlex, whole career)
Institution's track record	0 / 3	Capital Medical University: institution h-index 643 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 38915213)
Free to read	2 / 2	Free to read
Total	50 / 100	—

What each of these 20 components measures, and what this score is not →

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Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Yin, Y., Yang, H., Li, R., Wu, G., Qin, Q., & Tang, Y. (2024). A systematic review of the role of TREM2 in Alzheimer's disease. Chinese medical journal. https://doi.org/10.1097/cm9.0000000000003000

Vancouver

Yin Y, Yang H, Li R, Wu G, Qin Q, Tang Y. A systematic review of the role of TREM2 in Alzheimer's disease. Chinese medical journal. 2024. doi:10.1097/cm9.0000000000003000. PMID: 38915213.

BibTeX

@article{yin2024-38915213,
  author  = {Yin, Y. and Yang, H. and Li, R. and Wu, G. and Qin, Q. and Tang, Y.},
  title   = {{A systematic review of the role of TREM2 in Alzheimer's disease}},
  journal = {Chinese medical journal},
  year    = {2024},
  doi     = {10.1097/cm9.0000000000003000},
  pmid    = {38915213},
  url     = {https://doi.org/10.1097/cm9.0000000000003000}
}

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