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Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals
Yu JT, Jiang T, Wang YL, Wang HF, Zhang W, Hu N, Tan L, Sun L et al.. Neurobiology of aging, 2013-10-11
Topic: Brain proteins, microglia and lab models
Recent studies have reported that a rare mutation of triggering receptor expressed on myeloid cells 2 gene (TREM2 [rs75932628-T]) has significantly increased the risk of late-onset Alzhemier's disease (LOAD) in European-descendent population. To date, no study has investigated the association between rare mutations of TREM2 and LOAD risk in non-European population. Here, we sequenced exon2 of TREM2 in the northern Han Chinese population consisting of 1133 patients with LOAD and 1159 control subjects.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Yu, J. T., Jiang, T., Wang, Y. L., Wang, H. F., Zhang, W., Hu, N., et al. (2014). Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2013.10.075
Vancouver
Yu JT, Jiang T, Wang YL, Wang HF, Zhang W, Hu N, et al. Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals. Neurobiology of aging. 2014. doi:10.1016/j.neurobiolaging.2013.10.075. PMID: 24184202.
BibTeX
@article{yu2014-24184202,
author = {Yu, J. T. and Jiang, T. and Wang, Y. L. and Wang, H. F. and Zhang, W. and Hu, N. and Tan, L. and Sun, L. and others},
title = {{Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals}},
journal = {Neurobiology of aging},
year = {2014},
doi = {10.1016/j.neurobiolaging.2013.10.075},
pmid = {24184202},
url = {https://doi.org/10.1016/j.neurobiolaging.2013.10.075}
}
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Key findings
- To date, no study has investigated the association between rare mutations of TREM2 and LOAD risk in non-European population.
- Here, we sequenced exon2 of TREM2 in the northern Han Chinese population consisting of 1133 patients with LOAD and 1159 control subjects.
- Although, 4 novel mutations (c.102G>A: Val34Val, c.330C>T: Cys110Cys, c.342T>C: His114His, and c.343G>A: Gly115Ser) were identified in patients with LOAD, none of them exhibited significant association with LOAD risk after Bonferroni correction.
- Most importantly, the previously reported rare variants in European-descendent population including rs75932628-T (predicted to cause an R47H substitution) were absent in our cohort.
Why it matters
The TREM2 R47H variant (rs75932628-T), linked to higher late-onset Alzheimer's risk in people of European descent, was absent from this study of 1,133 patients and 1,159 controls of northern Han Chinese descent. Sequencing exon 2 of TREM2 turned up four previously unreported variants, but none was significantly associated with Alzheimer's risk after Bonferroni correction. This suggests the European R47H finding may not carry over to this population; it does not rule out other TREM2 variants or show any treatment.
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Study details
- Participants1,133
- Evidence strengthModerate
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,133 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 68 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.9 citations a year over 14 year(s) since 2014 |
| Impact for its field and year | 3 / 6 | Cited 5.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 22 other studies in this library |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Lan Tan: h-index 102 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Nanjing Medical University: institution h-index 508 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24184202) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 51 / 100 | — |
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