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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. NAD + in Brain Aging and Neurodegenerative Disorders

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cell metabolism 2019-10-01 Disease mechanisms

    NAD + is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival.

  2. Ageing as a risk factor for neurodegenerative disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Nature reviews. Neurology 2019-09-09 Disease mechanisms

    Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD).

  3. Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Gut 2019-08-30 Disease mechanisms

    These results indicate that microbiota-mediated intestinal and systemic immune aberrations contribute to the pathogenesis of AD in ADLP APT mice, providing new insights into the relationship between the gut (colonic gene expression, gut permeability), blood (blood immune cell population) and brain (pathology) axis and AD (memory deficits).

  4. Diabetes drugs in the fight against Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Ageing research reviews 2019-07-19 Drug development

    Alzheimer's disease (AD) is the most prevalent form of dementia, particularly in old age subjects.

  5. The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Life sciences 2019-06-13 Drug development

    These data suggest that the neuroprotective effects of liraglutide on diabetes-induced cognitive impairments are associated with the improvements of hippocampal synapses and inhibition of neuronal apoptosis.

  6. DPP-4 inhibitor improves learning and memory deficits and AD-like neurodegeneration by modulating the GLP-1 signaling

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuropharmacology 2019-06-12 Drug development

    Glucagon-like peptide-1 (GLP-1) signaling in the brain plays an important role in the regulation of glucose metabolism, which is impaired in Alzheimer's disease (AD).

  7. Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Behavioural brain research 2019-05-10 Drug development

    The role of mitochondrial dysfunction has been well-documented in Alzheimer's disease (AD).

  8. Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. CNS drugs 2019-03-01 Drug development

    The current absence of effective treatments for Alzheimer's disease (AD) and Parkinson's disease (PD) reflects an incomplete knowledge of the underlying disease processes.

  9. Fructooligosaccharides Ameliorating Cognitive Deficits and Neurodegeneration in APP/PS1 Transgenic Mice through Modulating Gut Microbiota

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of agricultural and food chemistry 2019-02-28 Drug development

    Alzheimer's disease (AD) is closely related to gut microbial alteration.

  10. Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Biochemical and biophysical research communications 2019-02-14 Drug development

    Dulaglutide, a novel long-acting glucagon-like peptide 1 (GLP-1) receptor agonist, is an incretin mimetic approved for type 2 diabetes mellitus (T2DM) treatment.

  11. Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Molecular neurobiology 2019-02-12 Biomarkers

    Hesperetin is a bioactive flavonoid in the body, produced from hesperidin.

  12. The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroendocrinology 2019-02-01 Disease mechanisms

    The gut microbiota has emerged as an environmental factor that modulates the development of the central nervous system (CNS) and the enteric nervous system (ENS).

  13. Chitosan oligosaccharide (COS): An overview

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. International journal of biological macromolecules 2019-01-29 Drug development

    The frequently studied polysaccharide, chitosan oligosaccharide/chitooligosaccharide (COS) is the major degradation product of chitosan/chitin via chemical hydrolysis or enzymatic degradation involving deacetylation and depolymerization processes.

  14. Recent Advances in the Understanding of the Health Benefits and Molecular Mechanisms Associated with Green Tea Polyphenols

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of agricultural and food chemistry 2019-01-17 Disease mechanisms

    Tea, leaf, or bud from the plant Camellia sinensis, make up some of the beverages popularly consumed in different parts of the world as green tea, oolong tea, or black tea.

  15. Gut microbiota in neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroimmunology 2019-01-09 Disease mechanisms

    Gut dysbiosis, a primary factor behind various gastrointestinal disorders may also augment lipopolysaccharides, pro-inflammatory cytokines, T helper cells and monocytes causing increased intestinal and BBB permeability via microbiota-gut-brain axis.

  16. Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Experimental gerontology 2018-12-06 Prevention trials

    It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1 TG ).

  17. Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2018-11-27 Biomarkers

    Cognitive decline and memory impairment induced by oxidative brain damage are the critical pathological hallmarks of Alzheimer's disease (AD).

  18. Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuropharmacology 2018-11-11 Drug development

    Obesity and type 2 diabetes mellitus (T2DM) are important risk factors for Alzheimer's disease (AD).

  19. Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurochemistry international 2018-08-14 Disease mechanisms

    The number of bacterial cells living within the human body is approximately equal to, or greater than, the total number of human cells.

  20. Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain research 2018-04-27 Drug development

    Recent studies indicate that metabolic disorders such as diabetes and obesity are a major risk factor of psychiatric diseases.

  21. Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain, behavior, and immunity 2018-03-29 Drug development

    Cognitive dysfunction and neuroinflammation are typical in Alzheimer's disease (AD), but are also associated with normal aging, albeit less severely.

  22. Causes of hyperhomocysteinemia and its pathological significance

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Archives of pharmacal research 2018-03-19 Risk factors

    In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases.

  23. Glucagon like peptide-1 (GLP-1) likes Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Diabetes & metabolic syndrome 2018-03-16 Drug development

    Glucagon-like peptide-1 (GLP-1) is a 30 amino acid long peptide hormone derived from the proglucagon gene and secreted in the distal small intestine when food enters the duodenum.

  24. DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. European journal of pharmacology 2018-03-15 Drug development

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there is no cure.

  25. A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Hippocampus 2018-03-05 Drug development

    Type 2 diabetes mellitus (T2DM) is an important risk factor for Alzheimer's disease (AD).

From across this topic

10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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