This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Genetics

Topic: Genetics and APOE

Plain-language summary

We investigated associations between apolipoprotein E (APOE) alleles and motor manifestations in Alzheimer's dementia (AD) capitalizing on National Alzheimer's Coordinating Center data: the baseline evaluations of older adults (≥60 years) with a diagnosis of AD were analyzed. Those with a concomitant diagnosis Parkinson's disease or other parkinsonian syndrome, and those treated with anti-parkinsonian agents were excluded. Three APOE groups were formed: APOE2 (APOE2 carriers), APOE3 (APOE3/APOE3) and APOE4 (APOE4/APOE4, APOE4/APOE3). UPDRS-III was used to assess the presence or absence of motor signs in 9 domains. Adjusted binary logistic models featuring the three APOE groups as exposures and motor domains as outcomes were estimated. There were 389 individuals in the APOE2, 1799 in the APOE3 and 2791 in the APOE4 groups. Compared to the APOE2 group, individuals in the APOE4 group had lower odds of having at least one motor sign [0.64 (0.50-0.82)]. Among motor signs, rigidity [0.53 (0.34-0.81)], bradykinesia [0.56 (0.40-0.77)], impaired chair rise [0.54 (0.37-0.78)] and impaired posture-gait [0.54 (0.36, 0.81)] exhibited significant associations. Exploratory analyses featuring APOE genotypes suggested dose-response relationships for both APOE2 and APOE4. In conclusion, APOE2 confers a risk towards motor (mainly parkinsonian) signs in AD. APOE4 may have a protective effect.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Liampas, I., Demiri, S., Siokas, V., Tsika, A., Marogianni, C., Stamati, P., et al. (2025). Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia. International journal of molecular sciences. https://doi.org/10.3390/ijms26178562

Vancouver

Liampas I, Demiri S, Siokas V, Tsika A, Marogianni C, Stamati P, et al. Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia. International journal of molecular sciences. 2025. doi:10.3390/ijms26178562. PMID: 40943487.

BibTeX

@article{liampas2025-40943487,
  author  = {Liampas, Ioannis and Demiri, Silvia and Siokas, Vasileios and Tsika, Antonia and Marogianni, Chrysa and Stamati, Polyxeni and Nasios, Grigorios and Messinis, Lambros and others},
  title   = {{Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.3390/ijms26178562},
  pmid    = {40943487},
  url     = {https://doi.org/10.3390/ijms26178562}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record lists 389 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

Compared to the APOE2 group, individuals in the APOE4 group had lower odds of having at least one motor sign [0.64 (0.50-0.82)].
Among motor signs, rigidity [0.53 (0.34-0.81)], bradykinesia [0.56 (0.40-0.77)], impaired chair rise [0.54 (0.37-0.78)] and impaired posture-gait [0.54 (0.36, 0.81)] exhibited significant associations.
In conclusion, APOE2 confers a risk towards motor (mainly parkinsonian) signs in AD.

New to this subject? Start with our plain-English guide: Genetics →

Study details

Participants389
Evidence strengthLow

How this study scored 52/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 29 of the 56 points we could judge it on, which is 52 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (International journal of molecular sciences)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	389 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multicenter collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40943487)
Free to read	— / 2	Access not recorded — left out of this score
Points	29 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 29 of the 56 points we could judge it on is 52 out of 100.
Total	52 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.

Studies in the library that share something with this one. The line above each title says what.

Related studies in Genetics from nearby years

Also tagged “apoe2”

265 studies in the library carry the topic tag “apoe2”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 265 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Genetics

See all studies in Genetics →