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Home › Research › Topics › down

down

534 studies tagged down, dated 1975-09-01 to 2026-10-30. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction 2026-10-30
  2. Memory and Plasma pTau217 Refine Prognosis in Down Syndrome 2026-10-02
  3. Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease 2026-10-01

Studies

534 studies carry this tag.

Date range

1975 to 2026

Top journals

  • Proceedings of the National Academy of Sciences of the United States of America 21
  • Alzheimer s & Dementia 20
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 15
  • Neurology 14
  • Neuroscience letters 14

239 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Senile myoclonic epilepsy of Genton: two cases in Down syndrome with dementia and late onset epilepsy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Epilepsy research 2007-10-24 Down syndrome and Alzheimer's

    Senile myoclonic epilepsy of Genton is a newer epileptic syndrome of the older patients with Down syndrome associated with an Alzheimer-type dementia.

  2. Gene expression profiling in the adult Down syndrome brain

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Genomics 2007-10-22 Down syndrome and Alzheimer's

    The mechanisms by which trisomy 21 leads to the characteristic Down syndrome (DS) phenotype are unclear.

  3. DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2007-09-28 Down syndrome and Alzheimer's

    Most individuals with Down syndrome show early onset of Alzheimer disease (AD), resulting from the extra copy of chromosome 21.

  4. Potential interaction between the GARS-AIRS-GART Gene and CP2/LBP-1c/LSF transcription factor in Down syndrome-related Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 26 out of 100. Cellular and molecular neurobiology 2007-09-28 Down syndrome and Alzheimer's

    (1) GARS-AIRS-GART is an important candidate gene in studies of Down syndrome (DS)-related Alzheimer's disease (AD), due to its chromosomal localization (21q22.1) in the Down syndrome critical region, involvement in de novo purine biosynthesis, and over-expression in DS brain.

  5. Symptoms of dementia among adults with Down's syndrome: a qualitative study

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of intellectual disability research : JIDR 2007-09-01 Digital health tools

    This study highlights the similarities in the clinical presentation of dementia among the general population and people with DS with a particular emphasis on the earlier appearance of symptoms associated with the frontal lobe dysfunction among adults with DS.

  6. Aging and Down syndrome: implications for physical therapy

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Physical therapy 2007-08-21 Down syndrome and Alzheimer's

    The number of people over the age of 60 years with lifelong developmental delays is predicted to double by 2030.

  7. Genome-wide expression analysis of cultured trophoblast with trisomy 21 karyotype

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Human reproduction (Oxford, England) 2007-07-17 Down syndrome and Alzheimer's

    Our results demonstrate that gene expression in trisomy 21 affected placentas significantly differs from that of chromosomally normal placentas, and this difference is only partially explained by over-expression of genes from chromosome 21.

  8. Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Archives of neurology 2007-07-01 Down syndrome and Alzheimer's

    Elevations in plasma Abeta(42) peptide levels are associated with earlier onset of AD and increased risk of death.

  9. Neuropsychiatric and behavioral aspects of trisomy 21

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Current psychiatry reports 2007-04-01 Down syndrome and Alzheimer's

    Down syndrome (DS), or trisomy 21, is the most common identifiable genetic cause of mental retardation.

  10. Forensic issues in Down syndrome fatalities

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. Journal of forensic and legal medicine 2007-03-26 Down syndrome and Alzheimer's

    Down syndrome, or trisomy 21, is the most common chromosomal abnormality associated with intellectual impairment.

  11. Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2007-03-01 Down syndrome and Alzheimer's

    Adults with Down syndrome (DS) develop Alzheimer disease (AD) pathology progressively with age but clinical signs of dementia are delayed by at least 10 years after the first signs of disease.

  12. Increased amyloid beta protein levels in children and adolescents with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of the neurological sciences 2007-02-02 Down syndrome and Alzheimer's

    The over expression of APP gene in DS leads to increases in plasma Abeta40 and Abeta42 levels before plaque formation in DS brain.

  13. Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Journal of autism and developmental disorders 2007-01-13 Down syndrome and Alzheimer's

    This review discusses the laboratory and clinical research supporting the rationale for the efficacy of donepezil (Aricept USA) in enhancing cognition in autism, Alzheimer disease, Down syndrome, traumatic brain injury, Attention Deficit Hyperactivity Disorder (ADHD), and schizophrenia.

  14. Beta-amyloid, oxidative stress and down syndrome

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current Alzheimer research 2006-12-01 Down syndrome and Alzheimer's

    Down syndrome (DS) provides a model for studying important aspects of Alzheimer disease (AD).

  15. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Human molecular genetics 2006-11-29 Genetics

    We scanned throughout chromosome 21 to assess genetic associations with late-onset Alzheimer disease (AD) using 374 Japanese patients and 375 population-based controls, because trisomy 21 is known to be associated with early deposition of beta-amyloid (Abeta) in the brain.

  16. Senile myoclonic epilepsy in Down syndrome: a video and EEG presentation of two cases

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Epileptic disorders : international epilepsy journal with videotape 2006-09-01 Down syndrome and Alzheimer's

    Myoclonic epilepsy is being increasingly recognized as a late-onset complication in middle-aged or elderly patients with Down syndrome, in association with cognitive decline.

  17. Reduced short latency afferent inhibition in patients with Down syndrome and Alzheimer-type dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2006-08-22 Down syndrome and Alzheimer's

    Our findings suggest that, with respect to this putative marker of central cholinergic activity, dementia in aging DS shares pathophysiological similarities to AD in the general population.

  18. 99mTc-HMPAO brain perfusion single-photon emission computed tomography in children with Down syndrome: relationship to epilepsy, thyroid functions, and congenital heart disease

    ✓ Peer-reviewed alzhub usefulness score 26 out of 100. Journal of child neurology 2006-07-01 Down syndrome and Alzheimer's

    In recent years, it has been possible for patients with Down syndrome to live longer with advanced medical treatment and social support.

  19. Telemedicine, dementia and Down syndrome: implications for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2006-07-01 Down syndrome and Alzheimer's

    This study supports the need for formal reliability and validity studies of TM preparatory to the consideration of this modality for use in clinical trials for AD.

  20. The effect of acetyl-L-carnitine administration on persons with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Research in developmental disabilities 2006-04-18 Down syndrome and Alzheimer's

    Since previous investigations reported improvements in cognition of patients with dementia after acetyl-L-carnitine therapy and since there is an increased risk for persons with Down syndrome to develop Alzheimer disease, this study was designed to investigate the effect of acetyl-L-carnitine administration on neurological, intellectual, and social functions in adults with Down syndrome.

  21. Brain and brawn: parallels in oxidative strength

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neurology 2006-01-01 Down syndrome and Alzheimer's

    Neuronal oxidative stress occurs early in the progression of Alzheimer disease (AD), significantly before the development of the pathologic hallmarks, neurofibrillary tangles, and senile plaques.

  22. Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurology 2006-01-01 Down syndrome and Alzheimer's

    Frameshift (+1) proteins such as APP(+1) and UBB(+1) accumulate in sporadic cases of Alzheimer disease (AD) and in older subjects with Down syndrome (DS).

  23. Soluble amyloid-beta in the brain: the scarlet pimpernel

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Journal of Alzheimer's disease : JAD 2006-01-01 Down syndrome and Alzheimer's

    Researchers since the 1990s have predominantly focused on the amyloid hypothesis and the formation of amyloid fibrils as the culprit behind AD when we began working on soluble Abeta (sAbeta).

  24. Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Archives of general psychiatry 2005-12-01 Down syndrome and Alzheimer's

    Adults with DS have a significantly increased brain concentration of myo-inositol, and this is associated with reduced cognitive ability.

  25. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Neurobiology of disease 2005-11-01 Down syndrome and Alzheimer's

    DYRK1A, dual-specificity tyrosine-regulated kinase 1A, maps to human chromosome 21 within the Down syndrome (DS) critical region.

  26. Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005-09-01 Down syndrome and Alzheimer's

    Down syndrome (DS) patients suffer from mental retardation, but also display enhanced beta-APP production and develop cortical amyloid plaques at an early age.

  27. Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. The Journal of biological chemistry 2005-08-09 Down syndrome and Alzheimer's

    Familial Danish dementia is an early onset autosomal dominant neurodegenerative disorder linked to a genetic defect in the BRI2 gene and clinically characterized by dementia and ataxia.

  28. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of biological chemistry 2005-06-29 Down syndrome and Alzheimer's

    Beta-secretase (BACE1) is the rate-limiting protease for the generation of the amyloid beta-peptide (Abeta) in Alzheimer disease.

  29. Down syndrome, Alzheimer's disease and seizures

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain & development 2005-06-01 Down syndrome and Alzheimer's

    Neuropathologically, Alzheimer-type abnormalities are demonstrated in patients with Down syndrome (DS), both demented and nondemented and more than a half of patients with DS above 50 years develop Alzheimer's disease (AD).

  30. Alzheimer disease and Down syndrome: factors in pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurobiology of aging 2005-03-01 Down syndrome and Alzheimer's

    There is evidence to suggest that certain shared features exist in the pathogenesis of vascular disease and Alzheimer disease (AD) in the general population.

  31. Learning and memory as a function of age in Down syndrome: a study using animal-based tasks

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Progress in neuro-psychopharmacology & biological psychiatry 2005-03-01 Down syndrome and Alzheimer's

    Individuals with Down syndrome (DS) are at a high risk for developing Alzheimer disease (AD) after the age 40; however, low levels of intellectual functioning, coupled with impaired language ability, confound the detection of AD.

  32. Extracellular deposits of A beta produced in cultures of Alzheimer disease brain vascular smooth muscle cells

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Journal of neuropathology and experimental neurology 2005-01-01 Down syndrome and Alzheimer's

    Alzheimer disease (AD) and Down syndrome (DS) brains contain deposits of amyloid-beta peptide that are located extracellularly in the neuropil and in blood vessels walls.

  33. Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Molecular vision 2004-10-25 Down syndrome and Alzheimer's

    The present findings demonstrate several fundamental parallels between lens and neuron vesicle trafficking cell biology and development, and suggest that more extensive AbetaPP related vesicle trafficking disease mechanisms may be shared by lens and brain.

  34. Cholinesterase inhibitors: new roles and therapeutic alternatives

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Pharmacological research 2004-10-01 Down syndrome and Alzheimer's

    An important aspect of brain cholinesterase function is related to enzymatic differences.

  35. High capacity and low cost detection of prion protein gene variant alleles by denaturing HPLC

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Journal of neuroscience methods 2004-10-01 Down syndrome and Alzheimer's

    Mutations in the human prion protein gene (PRNP) are responsible for hereditary diseases called transmissible spongiform encephalopathies (TSE) and a polymorphic site at codon 129 determines sensitivity to infectious forms of these maladies.

  36. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. The American journal of pathology 2004-07-01 Down syndrome and Alzheimer's

    Collagenous Alzheimer amyloid plaque component (CLAC) is a unique non-Abeta amyloid component of senile plaques (SP) derived from a transmembrane collagen termed CLAC-precursor.

  37. Trisomy 21 and the brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuropathology and experimental neurology 2004-07-01 Down syndrome and Alzheimer's

    In fetuses with Down syndrome, neurons fail to show normal dendritic development, yielding a "tree in winter" appearance.

  38. Neurodegenerative disorders associated with diabetes mellitus

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of molecular medicine (Berlin, Germany) 2004-06-03 Down syndrome and Alzheimer's

    More than 20 syndromes among the significant and increasing number of degenerative diseases of neuronal tissues are known to be associated with diabetes mellitus, increased insulin resistance and obesity, disturbed insulin sensitivity, and excessive or impaired insulin secretion.

  39. Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2004-06-01 Down syndrome and Alzheimer's

    An important lesion in Alzheimer's disease (AD) patient brains is the neurofibrillary tangle (NFT).

  40. Influence of the amyloid precursor protein locus on dementia in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurology 2004-06-01 Down syndrome and Alzheimer's

    APP is an important locus predicting the age at onset of dementia in people with Down syndrome.

  41. Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. American journal of mental retardation : AJMR 2004-03-01 Down syndrome and Alzheimer's

    It has been clearly established that there is an increased incidence of early onset dementia of the Alzheimer type (DAT) in people who have Down syndrome.

  42. Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Clinica chimica acta; international journal of clinical chemistry 2004-03-01 Down syndrome and Alzheimer's

    Our data supported the presumption of increased oxidative stress in DS.

  43. Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: an in vitro model of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Neuroscience 2004-01-01 Down syndrome and Alzheimer's

    Neurodegeneration in fetal development of Down syndrome (DS) patients is proposed to result in apparent neuropathological abnormalities and to contribute to the phenotypic characteristics of mental retardation and premature development of Alzheimer disease.

  44. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neuropathology and experimental neurology 2003-09-01 Down syndrome and Alzheimer's

    Aged individuals with Down syndrome (DS) develop senile plaques and neurofibrillary tangles consistent with Alzheimer disease (AD).

  45. Progressive worsening of adaptive functions in Down syndrome may be mediated by the complexing of soluble Abeta peptides with the alpha 7 nicotinic acetylcholine receptor: therapeutic implications

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Clinical neuropharmacology 2003-09-01 Down syndrome and Alzheimer's

    In persons with Down syndrome, soluble Abeta peptides, which result from the processing of the amyloid precursor protein, appear in the brain decades before the extracellular deposition of neuritic plaques.

  46. Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. American journal of medical genetics. Part A 2003-07-01 Down syndrome and Alzheimer's

    Dementia of the Alzheimer type (DAT) is common in older persons with Down syndrome (DS).

  47. The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of neurology 2003-06-01 Down syndrome and Alzheimer's

    Recently, a frequent prion protein gene (PRNP) polymorphism consisting of a methionine (M) for valine (V) substitution at codon 129 has been associated with cognitive impairment in elderly individuals.

  48. Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 2003-05-01 Down syndrome and Alzheimer's

    Plasma amyloid beta protein 1-40 (Abeta40) and Abeta42 levels were quantitated from 28 young Down syndrome (DS) (20-40 years old), 28 age-matched controls, 32 old DS (41-65 years old) and 32 age-matched controls in a sandwich enzyme-linked immunosorbent assay.

  49. Characteristic developmental expression of amyloid beta40, 42 and 43 in patients with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain & development 2003-04-01 Down syndrome and Alzheimer's

    We immunohistochemically studied the expression of beta-amyloid precursor protein (APP), Abeta40, Abeta42, and Abeta43 in the frontal lobes of 20 Down syndrome (DS) patients and 13 controls.

  50. Mortality and cancer incidence among individuals with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Archives of internal medicine 2003-03-01 Down syndrome and Alzheimer's

    Individuals with DS have a substantially increased risk of mortality due to specific causes and may have an elevated risk of other incident cancers in addition to leukemia.

From across this tag

10 of the 527 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts