Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Intraindividual cognitive decline using a brief computerized cognitive screening test

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2012-01-01 Cognitive tests and assessment

    Intraindividual decline in cognitive performance can be detected in otherwise healthy, community-dwelling, older persons, and this may deserve further study as a potential indicator of early Alzheimer's disease pathology.

  2. Reshaping the mind: The benefits of bilingualism

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Canadian Journal of Experimental Psychology/Revue canadienne de psychologie expérimentale 2011-09-12 Risk factors

    Studies have shown that bilingual individuals consistently outperform their monolingual counterparts on tasks involving executive control.

  3. MDS Task Force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Movement disorders : official journal of the Movement Disorder Society 2011-06-09 Getting a diagnosis

    There is controversy regarding the definition and characteristics of mild cognitive impairment in Parkinson's disease.

  4. The natural history of treated Parkinson's disease in an incident, community based cohort

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neurology, neurosurgery, and psychiatry 2011-05-18 Digital health tools

    Dementia risk is associated with increased age, impaired baseline semantic fluency and the MAPT H1/H1 genotype.

  5. Multimodal classification of Alzheimer's disease and mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. NeuroImage 2011-01-12 Tau biomarkers

    However, most existing research focuses on only a single modality of biomarkers for diagnosis of AD and MCI, although recent studies have shown that different biomarkers may provide complementary information for the diagnosis of AD and MCI.

  6. Episodic memory decline predicts cortical amyloid status in community-dwelling older adults

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Alzheimer's disease : JAD 2011-01-01 Cognitive tests and assessment

    Intra-individual decline in memory and cognition is characteristic of prodromal Alzheimer's disease (AD) and may allow detection of very early AD pathology.

  7. Abnormal cortical networks in mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PLoS computational biology 2010-11-18 Brain scans and imaging

    Recently, many researchers have used graph theory to study the aberrant brain structures in Alzheimer's disease (AD) and have made great progress.

  8. New diagnostic EEG markers of the Alzheimer's disease using visibility graph

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neural transmission (Vienna, Austria : 1996) 2010-08-17 Digital health tools

    A new chaos-wavelet approach is presented for electroencephalogram (EEG)-based diagnosis of Alzheimer's disease (AD) employing a recently developed concept in graph theory, visibility graph (VG).

  9. Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 2010-06-02 Disease mechanisms

    Age-associated memory impairment (AAMI) occurs in many mammalian species, including humans.

  10. Untreated poor vision: a contributing factor to late-life dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. American journal of epidemiology 2010-02-11 Costs and economics

    Ophthalmologic abnormalities have been described in patients with dementia, but the extent to which poor vision and treatment for visual disorders affect cognitive decline is not well defined.

  11. Structural brain changes in aging: courses, causes and cognitive consequences

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Reviews in the neurosciences 2010-01-01 Brain scans and imaging

    The structure of the brain is constantly changing from birth throughout the lifetime, meaning that normal aging, free from dementia, is associated with structural brain changes.

  12. Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain : a journal of neurology 2009-11-13 Brain scans and imaging

    Recent imaging evidence in Alzheimer's disease suggests that neural involvement in early-stage disease is more complex than is encapsulated in the commonly held position of predominant mesial temporal lobe degeneration-there is also early posterior cingulate cortex and diencephalic damage.

  13. Essential tremor--neurodegenerative or nondegenerative disease towards a working definition of ET

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Movement disorders : official journal of the Movement Disorder Society 2009-10-01 Risk factors

    Essential tremor (ET) is a syndrome of tremor in posture and movement, but recent studies have revealed additional cerebellar motor disturbances, cognitive disturbances, personality changes, hearing loss, and olfactory deficits.

  14. Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. International journal of geriatric psychiatry 2009-02-01 Risk factors

    The MoCA appears to have utility as a cognitive screen for early detection of AD and for MCI and warrants further investigation regarding its applicability in primary care settings, varying ethnic groups, and younger at-risk individuals.

  15. Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain : a journal of neurology 2008-10-24 Brain scans and imaging

    In this study we examined changes in the large-scale structure of resting-state brain networks in patients with Alzheimer's disease compared with non-demented controls, using concepts from graph theory.

  16. Network analysis of intrinsic functional brain connectivity in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PLoS computational biology 2008-06-27 Brain scans and imaging

    Functional brain networks detected in task-free ("resting-state") functional magnetic resonance imaging (fMRI) have a small-world architecture that reflects a robust functional organization of the brain.

  17. Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain 2007-12-03 Brain scans and imaging

    Although the patterns of structural and metabolic brain alterations in Alzheimer's disease are being refined and discrepancies between them are being underlined, the exact relationships between atrophy and hypometabolism are still unclear.

  18. Graph theoretical analysis of complex networks in the brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nonlinear biomedical physics 2007-07-05 Brain scans and imaging

    Since the discovery of small-world and scale-free networks the study of complex systems from a network perspective has taken an enormous flight.

  19. Neural basis of category-specific semantic deficits for living things: evidence from semantic dementia, HSVE and a neural network model

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain : a journal of neurology 2007-04-01 Digital health tools

    Studies of patients with semantic impairments following brain damage offer key insights into the cognitive and neural organization of semantic memory.

  20. The topography of grey matter involvement in early and late onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain : a journal of neurology 2007-02-09 Brain scans and imaging

    Clinical observations have suggested that the neuropsychological profile of early and late onset forms of Alzheimer's disease (EOAD and LOAD) differ in that neocortical functions are more affected in the former and learning in the latter, suggesting that they might be different diseases.

  21. Cognitive decline and literacy among ethnically diverse elders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of geriatric psychiatry and neurology 2005-12-01 Disparities

    Researchers on genetic and environmental influences on risk for Alzheimer's disease must be prepared for the growing ethnic and racial diversity of our participants.

  22. Visual dysfunction in Parkinson disease without dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 2005-11-09 Digital health tools

    Patients with mild to moderate Parkinson disease showed impaired visual perception and cognition compared with elderly control subjects.

  23. Sleep disturbance in mild to moderate Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Sleep medicine 2005-03-31 Risk factors

    Sleep disturbance in AD is associated with other behavioural symptoms, notably aggressiveness.

  24. Medial temporal lobe function and structure in mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 2004-07-01 Brain scans and imaging

    Functional magnetic resonance imaging (fMRI) was used to study memory-associated activation of medial temporal lobe (MTL) regions in 32 nondemented elderly individuals with mild cognitive impairment (MCI).

  25. Clinical predictive factors of subthalamic stimulation in Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain : a journal of neurology 2002-03-01 Digital health tools

    High-frequency stimulation of the subthalamic nucleus (STN) constitutes one of the most effective treatments for advanced forms of Parkinson's disease.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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