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  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Impact of occupational complexity on cognitive decline in the oldest-old

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Aging & mental health 2020-04-07 Risk factors

    Neither work complexity (p = 0.995) nor work duration (p = 0.701) showed a significant effect on the likelihood of presenting a lower cognitive profile or developing dementia (p = 0.385 and p = 0.096, for work complexity and work duration, respectively).

  2. Network localization of clinical, cognitive, and neuropsychiatric symptoms in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Brain : a journal of neurology 2020-04-01 Brain scans and imaging

    There is both clinical and neuroanatomical variability at the single-subject level in Alzheimer's disease, complicating our understanding of brain-behaviour relationships and making it challenging to develop neuroimaging biomarkers to track disease severity, progression, and response to treatment.

  3. Associations of the metabolic syndrome and its components with cognitive impairment in older adults

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. BMC geriatrics 2019-03-07 Risk factors

    Lower HDL-C was significantly associated with a higher odds of cognitive impairment (OR 2.70 per 1 mmol/L reduction; 95% CI 1.25, 5.56; p = 0.011), whereas BMI, TG, glucose and HbA1c were not (all p > 0.05).

  4. Depression and Alzheimer's Disease Biomarkers Predict Driving Decline

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Journal of Alzheimer's disease : JAD 2018 Brain scans and imaging

    Data were available from 131 participants with age ranging from 65.4 to 88.2 years and mean follow up of 2.4 years (SD = 1.0).

  5. Midlife Metabolic Profile and the Risk of Late-Life Cognitive Decline

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Journal of Alzheimer's disease : JAD 2017 Risk factors

    Among metabolic syndrome components, the effects of higher plasma glucose levels on cognitive decline (CD) have been considered in few studies.

  6. [Exercise and Physical Activity for Dementia Prevention]

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Brain and nerve = Shinkei kenkyu no shinpo 2016-07 Prevention trials

    The effects of exercise and physical activity on cognitive function and brain health have been established by longitudinal and intervention studies.

  7. Chronology and Chronicity of Altered Resting-State Functional Connectivity after Traumatic Brain Injury

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Journal of Neurotrauma 2015-02 Brain scans and imaging

    Whereas traumatic brain injury (TBI) results in widespread disruption of neural networks, changes in regional resting-state functional connectivity patterns after insult remain unclear.

  8. Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Dementia and geriatric cognitive disorders 2007-11-07 Clinical safety

    This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.

  9. Objectively Measured Visual Impairment and Dementia Prevalence in Older Adults in the US

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. JAMA ophthalmology 2023-08-01 Cognitive tests and assessment

    In this survey study, all types of objectively measured VI were associated with a higher dementia prevalence.

  10. A novel computer adaptive word list memory test optimized for remote assessment: Psychometric properties and associations with neurodegenerative biomarkers in older women without dementia

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2022-03-09 Cognitive tests and assessment

    The SLS is a valid and reliable self-administered memory test that shows promise for remote assessment of aging and neurodegenerative disorders.

  11. COVID-19 Artificial Intelligence Diagnosis Using Only Cough Recordings

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. IEEE open journal of engineering in medicine and biology 2020-09-29 Digital health tools

    When validated with subjects diagnosed using an official test, the model achieves COVID-19 sensitivity of 98.5% with a specificity of 94.2% (AUC: 0.97).

  12. Diagnosis of Alzheimer's Disease via Multi-Modality 3D Convolutional Neural Network

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Frontiers in neuroscience 2019-05-31 Digital health tools

    Alzheimer's disease (AD) is one of the most common neurodegenerative diseases.

  13. Prevalence of idiopathic normal pressure hydrocephalus: A prospective, population-based study

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. PloS one 2019-05-29 Digital health tools

    In this prospective, population-based study the prevalence of iNPH was 3.7% among individuals 65 years and older, and more common in the higher age group, 80 years and above.

  14. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Science translational medicine 2019-01-01 Brain scans and imaging

    In Alzheimer's disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic loss, brain atrophy, and cognitive impairment.

  15. Classification of Alzheimer's Disease by Combination of Convolutional and Recurrent Neural Networks Using FDG-PET Images

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Frontiers in neuroinformatics 2018-06-19 Digital health tools

    Alzheimer's disease (AD) is an irreversible brain degenerative disorder affecting people aged older than 65 years.

  16. The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: a cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. BMC neurology 2014-10-14 Prevention trials

    Our study is a unique resource of neuroimaging and cognitive measures relevant to change across the adult lifespan.

  17. Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 2011-04-01 Prevention trials

    Comorbid frontotemporal dementia is a negative prognostic indicator.

  18. Cognitive activity and incident AD in a population-based sample of older persons

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 2002-12-01 Prevention trials

    Frequency of participation in cognitively stimulating activities appears to be associated with risk of AD and may partially explain the association of educational and occupational attainment with disease risk.

  19. Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The American journal of psychiatry 2002-05-01 Brain scans and imaging

    Power analyses for voxels showing maximal decline over the 1-year period in regional cerebral glucose metabolism (mg/100 g per minute) were computed to estimate the sample sizes needed to detect a significant treatment response in a 1-year, double-blind, placebo-controlled treatment study.

  20. Prevalence of Alzheimer's Disease in a Community Population of Older Persons

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. JAMA 1989-11-10 How common it is

    Clinically diagnosed Alzheimer's disease and other dementing illnesses were assessed in a geographically defined US community.

  21. Dysfunctional resting state network connectivity predicts postoperative delirium after major surgery

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. British journal of anaesthesia 2025-12-31 Brain scans and imaging

    Group comparisons revealed significantly decreased within-network connectivity in salience-ventral attention, cognitive control, and default mode network in participants with postoperative delirium (n=31) compared with non-delirious participants (n=89; non-parametric permutation test, 1000 iterations, P<0.05).

  22. Joint association of cognitive reserve and frailty with incident Alzheimer's disease and related dementias

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Behavioural brain research 2025-07-15 Risk factors

    Cognitive reserve and frailty are factors associated with Alzheimer's disease and related dementias (ADRD).

  23. Mediterranean diet and brain functional connectivity in a population without dementia

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Frontiers in neuroimaging 2024-12-06 Prevention and risk

    Rs-fMRI analysis revealed significant associations between FC and MedDietScore.

  24. Validity of the Tablet-Based Digital Cognitive Test (SCST) in Identifying Different Degrees of Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of Korean medical science 2024-09-30 Cognitive tests and assessment

    The SCST total score, cognitive domain scores (attention, language, visuospatial function, memory, executive function), and most of the subtest scores decreased significantly in the order of SCD, MCI and dementia.

  25. Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of neurology, neurosurgery, and psychiatry 2024-08-16 Risk factors

    111 out of 287 participants had hearing impairment.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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