Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest in this topic

  1. Alcohol use disorder accelerates age-related cognitive decline 2026-09-23
  2. A longitudinal study of age-related traits and cognitive function: The Collaborative Amish Aging and Memory Project (CAAMP) 2026-09-20
  3. Associations of menopause hormone therapy with late-life cognition and brain health vary by formulation and APOEε4 presence 2026-09-20

Studies

1,142 studies carry this tag.

Date range

1986 to 2026

Top journals

  • Alzheimer s & Dementia 42
  • Neurology 41
  • Journal of the American Geriatrics Society 36
  • Journal of Alzheimer's disease : JAD 35
  • Nutrients 23

437 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Disparities in neighborhood food environment and cognitive decline among US older adults: a cohort study

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. BMC Medicine 2025-05-05 Risk factors

    The mean age of participants was 77.1 years (SD = 7.6), and 2779 were women (weighted % = 56.7).

  2. The impact of cognitive training and physical rehabilitation on activity and quality of life in elderly patients

    ✓ Peer-reviewed alzhub usefulness score 29 out of 100. Russian Journal of Geriatric Medicine 2025-05-05 Prevention trials

    RELEVANCE . With age, people experience a decline in cognitive and physical functions, which increases the risk of falls, loss of independence, and deterioration in quality of life.

  3. Eighty older adults with MCI (median age 86.50 years) participated, with an average attendance rate of 86.25% in the intervention group.

  4. Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Alzheimer s & Dementia 2025-05-01 Prevention and risk

    Among ACHIEVE participants in the top quartile of predicted risk, 3-year cognitive decline in the hearing intervention was 61.6% (95% confidence interval [CI]: 33.7%-94.1%) slower than the control.

  5. Regular use of opioids and dementia, cognitive measures, and neuroimaging outcomes among UK Biobank participants with chronic non‐cancer pain

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Alzheimer s & Dementia 2025-05-01 Long-term cohort studies

    Regular opioid use was associated with a 20% higher risk of all-cause dementia and a 49% higher risk of vascular dementia (VD) compared with those not using analgesics.

  6. The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Alzheimer s & Dementia 2025-05-01 How common it is

    Per- and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants.

  7. All ML models outperformed the MMSE alone.

  8. Association of Mediterranean Diet With Cognitive Decline Among Diverse Hispanic or Latino Adults From the Hispanic Community Health Study/Study of Latinos

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Carolina Digital Repository (University of North Carolina at Chapel Hill) 2025-04-29 Prevention trials

    A total of 6321 participants (mean [SE] age, 56.1 [0.18] years at visit 1; n = 4077 women [57.8%]) were included.

  9. Interventions That Support Lifestyle Behavior Change for Secondary Prevention of Stroke: A Scoping Review

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Stroke 2025-04-28 Prevention and risk

    Lifestyle behavioral change is a critical component for secondary prevention of stroke.

  10. Longitudinal Remote Sleep and Cognitive Research in Older Adults With Mild Cognitive Impairment and Dementia: Prospective Feasibility Cohort Study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. JMIR Aging 2025-04-28 Getting a diagnosis

    In total, 41 participants consented (n=10, 24% participants with Alzheimer disease; n=11, 27% participants with Lewy body disease; and n=20, 49% controls).

  11. No significant difference between the three groups in ADAS-Cog was found at the primary endpoint at 15 months (CPR vs health advice, β= -0·04 [95% CI -0·34 to 0·26]; RFM vs health advice, β= -0·14 [-0·44 to 0·15]; CPR vs RFM, β=0·10 [-0·19 to 0·40]) nor at the 6-month and 12-month follow-ups.

  12. Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. Alzheimer's & Dementia 2025-04-24 Clinical trials

    Exercise intensity did not differentially affect cognitive trajectory.

  13. Neuropsychological phenotypic characteristics in a cohort of community-based older adults: Data from the Framingham Heart Study

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of Alzheimer s Disease 2025-04-23 Long-term cohort studies

    BackgroundNeuropsychological (NP) assessment is crucial for diagnosing prodromal and Alzheimer's disease and related dementia (ADRD) syndromes.

  14. Cognitive and Neuropsychiatric Effects of 40 Hz tACS Simultaneously with Cognitive Exercises for Dementia: A Randomized, Crossover, Double-Blind, Sham-Controlled Study

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Medicina 2025-04-19 Cognitive tests and assessment

    Real tACS paired with cognitive exercises significantly improved ADAS-Cog scores post-treatment compared to pre-treatment (p-value = 0.019), whereas sham tACS did not.

  15. Nonlinear Associations of Accelerometer-Based Sedentary Time With Cognitive Functions in the UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journals of Gerontology Series B 2025-04-18 Long-term cohort studies

    Except for the visual-spatial memory test, nonlinear approaches provided a better fit than linear methods to model the associations of sedentary time with other cognitive outcomes.

  16. The effects of computer-based cognitive training on attention and working memory in Thai older adults with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Journal of Associated Medical Sciences 2025-04-12 Prevention trials

    The results showed that the experimental group had a statistically significant difference of attention (TMT-B) and working memory scores, while the control group had no statistically significant difference for both attention and working memory.

  17. In years when older adults subjectively reported fewer difficulties with their finances, they objectively performed better at financial tasks and this relationship became stronger over 10 years.

  18. The impact of tract‐ and county‐level segregation on 10‐year cognitive and everyday functioning outcomes of Black/African American older adults in the ACTIVE study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer s & Dementia Behavior & Socioeconomics of Aging 2025-04-06 Risk factors

    Higher segregation, indicated by lower tract and county-level interaction, was associated with better cognitive and everyday functioning levels but faster rates of decline.

  19. Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer s Research & Therapy 2025-04-05 Brain scans and imaging

    Cognitive decline is a condition affecting almost one sixth of the elder population and is widely regarded as one of the first manifestations of Alzheimer's disease.

  20. A comparative study of the EAT‐Lancet diet and the Mediterranean diet in relation to neuroimaging biomarkers and cognitive performance

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Alzheimer s & Dementia 2025-04-01 Prevention trials

    In multi-adjusted models, higher adherence to the EAT-Lancet diet was associated with higher total mean cortical thickness, and thicker cortex in Alzheimer's disease-signature regions, while a higher adherence to the MeDi was associated with better cognitive performance.

  21. Long sleep duration, cognitive performance, and the moderating role of depression: A cross‐sectional analysis in the Framingham Heart Study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer s & Dementia 2025-04-01 Long-term cohort studies

    Long sleep was associated with reduced overall cognitive function (β ± standard error = -0.25 ± 0.07, p < 0.001), with strongest effects in those with depressive symptoms using (-0.74 ± 0.30, p = 0.017) and not using antidepressants (-0.60 ± 0.26, p = 0.024).

  22. Scoping review exploring the impact of hip fracture in older adults with cognitive impairment or dementia

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. BMJ Open 2025-04-01 Clinical safety

    We identified 30 studies reporting health outcomes following hip fracture.

  23. Translation with ongoing adaptation and improvement (ToAI) framework: A community‐informed, structured, iterative approach to culturally adapting cognitive assessment tools

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Alzheimer s & Dementia Translational Research & Clinical Interventions 2025-04-01 Getting a diagnosis

    The ToAI framework followed a nine-step process: preparation, translation, native-speaker review, VIP team review, external panel review, pilot testing, proofreading, final formatting, and ongoing review and improvement.

  24. Social interaction as a unique form of reward – Insights from healthy ageing and frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuroscience & Biobehavioral Reviews 2025-03-30 Lewy body dementia

    The drive for positive social interactions, or "social rewards", is an important motivator of human behaviour, conferring several adaptive benefits.

  25. Nexus Between Exposure to Natural Outdoor Environments and Cognitive Competence among Older Adults in China

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Annals of the American Association of Geographers 2025-03-26 Risk factors

    With a rapidly aging population and an increasing number of older people with cognitive impairment, a multitude of social problems could arise.

  26. Longitudinal, Bidirectional Association between Gait Speed and Cognitive Function in Community-Dwelling Older Adults without Dementia

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Journal of the American Medical Directors Association 2025-03-25 Getting a diagnosis

    This study found a reciprocal association between gait speed and global or domain-specific cognition.

  27. The MIND diet, cognitive function, and well-being among healthy adults at midlife: a randomised feasibility trial

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. BMC Nutrition 2025-03-25 Prevention trials

    A repeated measures ANOVA showed that in comparison to the control group, both intervention groups significantly improved mood, quality of life, MIND diet score and all COM-B components at follow-up (p < 0.05).

  28. Effects of B Vitamins on Homocysteine Lowering and Thrombotic Risk Reduction—A Review of Randomized Controlled Trials Published Since January 1996

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nutrients 2025-03-24 Prevention and risk

    (cobalamin)-dependent pathways. Supplementation of B vitamins has been shown to effectively reduce plasma homocysteine levels.

  29. Cognitive Training and Enrichment Modulates Neural Plasticity and Enhances Cognitive Reserve in Aging Rats

    ✓ Peer-reviewed alzhub usefulness score 28 out of 100. Experimental Aging Research 2025-03-21 Prevention trials

    The Ct group and Ct+ee group performed significantly better than the control group in behavioural tasks and had improved dendrite profiles of DG and basal tree of CA1 region of hippocampus.

  30. Identifying Exercise Interventions That May Slow the Progression of Cognitive Decline in Older Adults With Mild Cognitive Impairment: A Scoping Review

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Cureus 2025-03-20 Mild cognitive impairment

    Mild cognitive impairment (MCI) is defined as the stage between normal cognitive changes that may occur with age and more serious symptoms that indicate dementia.

  31. Central Nervous System-Active Medication Use in Older Adults With and Without Dementia-A Retrospective Cohort Study

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Journal of general internal medicine 2025-03-19 Health systems and care delivery

    Central nervous system (CNS)-active medication use is common in older adults; however, there are limited data on utilization trends over time, differences in utilization amongst those with and without dementia, and modification of utilization surrounding dementia diagnosis.

  32. Adherence and intensity in multimodal lifestyle-based interventions for cognitive decline prevention: state-of-the-art and future directions

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Alzheimer s Research & Therapy 2025-03-17 Prevention and risk

    Preventing dementia and Alzheimer's disease (AD) is a global priority.

  33. Western Mediterranean diet predicts 9-year changes in episodic memory in an adult lifespan sample of Americans

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Journal of Alzheimer s Disease 2025-03-17 Prevention trials

    A wMD was related to slowed EM declines across sociodemographic populations in a national U.S. sample.

  34. Brain health PRO/Santé cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of Prevention of Alzheimer s Disease 2025-03-15 Risk factors

    Two logic models were developed to identify the determinants of risk for dementia and how these could be targeted by the program.

  35. Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Aging Cell 2025-03-12 Disparities

    We demonstrate that senolytic treatment is an effective therapeutic strategy to mitigate cognitive impairment by reducing neuroinflammation and associated metabolic disturbances.

  36. Ιnnovative Health Promotion Strategies: A 6-Month Longitudinal Study on Computerized Cognitive Training for Older Adults with Minor Neurocognitive Disorders

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. European Journal of Investigation in Health Psychology and Education 2025-03-12 Prevention trials

    Minor neurocognitive disorders (NCDs) represent a transitional phase between normal cognitive aging and dementia, highlighting the importance of early interventions.

  37. Effectiveness of exercise for improving cognition, memory and executive function: a systematic umbrella review and meta-meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 76 out of 100. British Journal of Sports Medicine 2025-03-06 Prevention and risk

    133 systematic reviews (2,724 RCTs and 258 279 participants) were included.

  38. Assessing Cognition Remotely: Expanding the Reach of Cognitive Testing for Older Adults at Risk for Dementia in a Randomized Controlled Trial

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Canadian Geriatrics Journal 2025-03-05 Getting a diagnosis

    Little is known about whether cognitive assessments can be completed remotely by older adults at risk for dementia, and there is no consensus on which tool is best.

  39. Unlocking Cognitive Potential: Exploring a Virtual Environment for Cognitive Training in Healthy Aging and Mild Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. IRBM 2025-03-05 Prevention trials

    This study aims to investigate how cognitive impairment and social presence influence goal attainment in an ecological virtual environment.

  40. Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort: An exploratory study

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Alzheimer s & Dementia 2025-03-01 Risk factors

    Neighborhood disadvantage was associated with worse cognitive performance on memory, executive function, processing speed, and preclinical Alzheimer's tests on both datasets.

  41. Feasibility and acceptability of a remote computerized cognitive training employing telehealth in older adults with subjective cognitive complaints

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Digital Health 2025-03-01 Prevention trials

    A significant improvement in mental flexibility and planning abilities was observed in both groups (as measured by the Zoo planning test), but no other neuropsychological tests showed improvement.

  42. In this study, 122 individuals were divided into two groups.

  43. Brain age mediates gut microbiome dysbiosis-related cognition in older adults

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer s Research & Therapy 2025-02-27 Cognitive tests and assessment

    Two clusters were identified in the microbiota at the phylum level that showed significant differences on a few microbiotas phylum.

  44. The Effect of Aerobic or Strength Training in Elderly with Cognitive Decline: The Fit4Alz Project

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Sports Science and Medicine 2025-02-24 Prevention trials

    This study aimed to examine the effects of aerobic and strength training methodologies, either combined with or without cognitive training, on mitigating cognitive decline.

  45. Modifiable Lifestyle Risk Factors and Strategies for Slowing the Progression of Age-Related Macular Degeneration

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Vision 2025-02-23 Prevention and risk

    Age-related macular degeneration (AMD) is a multifactorial disorder influenced by genetic, lifestyle, nutritional, and systemic health factors that contribute to increased oxidative stress and chronic inflammation in the retina.

  46. Investigating Modifiable Factors Associated with Cognitive Decline: Insights from the UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Biomedicines 2025-02-21 Long-term cohort studies

    Our findings revealed a significant impact of unfavorable medical and psychiatric histories on processing speed and visual episodic memory decline (Hazard Ratio (HR) = 1.34, 95% CI: 1.20–1.51, p = 6.06 × 10⁻7; HR = 1.50, 95% CI: 1.22–1.86, p = 1.62 × 10⁻4, respectively).

  47. COG-T CHD is the first clinical trial to evaluate the efficacy of computer-based cognitive training in patients with coronary heart disease, filling an important gap in the treatment evidence for cognitive digital therapy.

  48. Long-Term Effect of Intensive vs Standard Blood Pressure Control on Mild Cognitive Impairment and Probable Dementia in SPRINT

    ✓ Peer-reviewed alzhub usefulness score 76 out of 100. Neurology 2025-02-11 Prevention and risk

    This long-term follow-up of the SPRINT randomized trial tested whether intensively lowering systolic blood pressure (to below 120, vs. the standard target of below 140) reduces the risk of thinking problems in adults 50+ with hypertension.

  49. Circulating metabolomic profile of the MIND diet and its relation to cognition in middle‐aged and older adults

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. iMetaOmics. 2025-02-10 Prevention trials

    The Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diet has been related to a lower risk of dementia and better cognitive function.

  50. Association Between Lifestyle at Different Life Periods and Brain Integrity in Older Adults

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. Neurology 2025-02-07 Treatments

    In 135 older adults (mean age = 69.3 years; women = 61.5%), no associations were found within AD-signature regions (all p > 0.25).

From across this tag

9 of the 1,134 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts