Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest in this topic

  1. Diagnostic accuracy of remote self-administered digital cognitive assessment by clinical diagnosis and Alzheimer's disease PET imaging biomarkers 2026-09-25
  2. Multi-scale 3D CNN with imbalance-aware training for structural MRI-based six-class Alzheimer disease staging 2026-09-22
  3. T1 mapping in Alzheimer’s disease: a quantitative MRI study with amyloid-PET correlation 2026-09-21

Studies

842 studies carry this tag.

Date range

1983 to 2026

Top journals

  • Neurology 83
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine 42
  • Brain : a journal of neurology 34
  • NeuroImage 31
  • Alzheimer s & Dementia 30

283 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. The role of neuroimaging in Alzheimer’s disease: implications for the diagnosis, monitoring disease progression, and treatment

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Exploration of neuroscience 2025-02-25 Brain scans and imaging

    Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of people worldwide.

  2. Identification of UBE2N as a biomarker of Alzheimer’s disease by combining WGCNA with machine learning algorithms

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Scientific Reports 2025-02-22 Digital health tools

    Alzheimer’s disease (AD) is the most common cause of dementia, emphasizing the critical need for the development of biomarkers that facilitate accurate and objective assessment of disease progression for early detection and intervention to delay its onset.

  3. Integrating Machine Learning and Environmental and Genetic Risk Factors for the Early Detection of Preclinical Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. The journals of gerontology. Series B, Psychological sciences and social sciences 2025-02-19 Risk factors

    This study classified preclinical Alzheimer's disease (AD) using cognitive screening, neighborhood deprivation via the area deprivation index (ADI), and sociodemographic and genetic risk factors.

  4. IRMA: Machine learning-based harmonization of $$^{18}$$F-FDG PET brain scans in multi-center studies

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. European Journal of Nuclear Medicine and Molecular Imaging 2025-02-18 Digital health tools

    IRMA can be used to learn and disregard center-specific information in features extracted from brain $$^{18}$$ 18 F-FDG PET scans, while retaining disease-specific information.

  5. Stacked CNN-based multichannel attention networks for Alzheimer disease detection

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Scientific Reports 2025-02-17 Brain scans and imaging

    Alzheimer's Disease (AD) is a progressive condition of a neurological brain disorder recognized by symptoms such as dementia, memory loss, alterations in behaviour, and impaired reasoning abilities.

  6. Validation of a novel neuroimaging signature for dementia and clinical Alzheimer's disease in the population-based Rotterdam study

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Journal of Alzheimer s Disease 2025-02-16 Long-term cohort studies

    BackgroundA novel neuroimaging signature of regional cortical thickness on brain MRI recently showed high potential for Alzheimer's disease and related dementias (ADRD) risk stratification in the community.

  7. ALZENET: Deep learning-based early prediction of Alzheimer's disease through magnetic resonance imaging analysis

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Telematics and Informatics Reports 2025-02-14 Brain scans and imaging

    Alzheimer's Disease (AD) is a particular form of dementiacharacterized by a steady decline in brain function and cognitive abilities, leading to memory loss, disorientation, and trouble doing daily tasks.

  8. Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer's disease: A head‐to‐head comparison of the LEADS and ADNI cohorts

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer s & Dementia 2025-02-01 Long-term cohort studies

    After controlling for the level of cognitive impairment, we found a double dissociation between AD clinical phenotype and localization/magnitude of atrophy, characterized by predominant neocortical involvement in EOAD and more focal anterior medial temporal involvement in LOAD.

  9. Tracer kinetic model detecting heterogeneous blood–brain barrier permeability to water and contrast agent in Alzheimer's disease and dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Alzheimer s & Dementia 2025-02-01 Lewy body dementia

    AD patients exhibited a significant reduction in the water exchange rates across the BBB, whereas DLB patients showed a significant increase in BBB permeability to contrast agent.

  10. UK Biobank MRI data can power the development of generalizable brain clocks: A study of standard ML/DL methodologies and performance analysis on external databases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. NeuroImage 2025-01-30 Long-term cohort studies

    In this study, we present a comprehensive pipeline to train and compare a broad spectrum of machine learning and deep learning brain clocks, integrating diverse preprocessing strategies and correction terms.

  11. Changes in the Parietal Lobe Subregion Volume at Various Stages of Alzheimer’s Disease and the Role in Cognitively Normal and Mild Cognitive Impairment Conversion

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of Integrative Neuroscience 2025-01-21 Mild cognitive impairment

    The left inferior parietal lobule (IPL)_6_5 (rostroventral area 39) showed the best ability to discriminate between patients with AD and those with CN (AUC = 0.688).

  12. Data from 262 records (260 unique participants) were analyzed.

  13. Biomarker Investigation Using Multiple Brain Measures from MRI Through Explainable Artificial Intelligence in Alzheimer’s Disease Classification

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Bioengineering 2025-01-17 Digital health tools

    As the leading cause of dementia worldwide, Alzheimer’s Disease (AD) has prompted significant interest in developing Deep Learning (DL) approaches for its classification.

  14. Machine Learning-Based Alzheimer’s Disease Stage Diagnosis Utilizing Blood Gene Expression and Clinical Data: A Comparative Investigation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Diagnostics 2025-01-17 Digital health tools

    Utilizing clinical data, the highest ROC AUC scores attained were 0.989, 0.927, and 0.907 for the identification of the CN, MCI, and dementia stages, respectively.

  15. Artificial intelligence models using F-wave responses predict amyotrophic lateral sclerosis

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Brain 2025-01-16 Digital health tools

    Model scores two standard deviations below the mean had 4 months increased survival (two standard deviations below had 3 months decreased survival).

  16. Amygdala Nuclei Atrophy in Cognitive Impairment and Dementia: Insights from High-Resolution Magnetic Resonance Imaging

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Medicina 2025-01-15 Getting a diagnosis

    Significant amygdala atrophy was observed in multiple amygdala nuclei across cognitive performance groups, with more pronounced changes in the low-performance group.

  17. The global research of magnetic resonance imaging in Alzheimer’s disease: a bibliometric analysis from 2004 to 2023

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Frontiers in Neurology 2025-01-15 Brain scans and imaging

    A total of 13,659 articles were obtained in this study.

  18. Antiamyloid Therapy and Cerebral Blood Flow Changes on MRI: A Potential Longitudinal Biomarker of Treatment Response?

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. American Journal of Neuroradiology 2025-01-13 Treatments

    Amyloid-targeting therapy has recently become widely available in the United States for the treatment of patients with symptomatic mild Alzheimer disease (AD).

  19. Anterior-temporal network hyperconnectivity is key to Alzheimer’s disease: from ageing to dementia

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Brain 2025-01-09 Getting a diagnosis

    Our findings revealed distinct patterns of connectivity linked to normal ageing or Alzheimer's disease.

  20. The potential role of machine learning and deep learning in differential diagnosis of Alzheimer’s disease and FTD using imaging biomarkers: A review

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Neuroradiology Journal 2025-01-09 Digital health tools

    IntroductionThe prevalence of neurodegenerative diseases has significantly increased, necessitating a deeper understanding of their symptoms, diagnostic processes, and prevention strategies.

  21. Experiences from Clinical Research and Routine Use of Florbetaben Amyloid PET-A Decade of Post-Authorization Insights

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Pharmaceuticals (Basel, Switzerland) 2025-01-08 Health systems and care delivery

    Florbetaben (FBB) is a radiopharmaceutical approved by the FDA and EMA in 2014 for the positron emission tomography (PET) imaging of brain amyloid deposition in patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline.

  22. ReIU: an efficient preliminary framework for Alzheimer patients based on multi-model data

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Frontiers in Public Health 2025-01-03 Brain scans and imaging

    The rising incidence of Alzheimer's disease (AD) poses significant challenges to traditional diagnostic methods, which primarily rely on neuropsychological assessments and brain MRIs.

  23. In Vivo Head-to-Head Comparison of [18F]GTP1 with [18F]MK-6240 and [18F]PI-2620 in Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Nuclear Medicine 2025-01-02 Brain scans and imaging

    [18F]GTP1 exhibited retention patterns that correlated with [18F]PI-2620 and [18F]MK-6240 for all Braak regions (except Braak II).

  24. A Novel Approach to the Prediction of Alzheimer’s Disease Progression by Leveraging Neural Processes and a Transformer Encoder Model

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. IEEE Access 2025-01-01 Mild cognitive impairment

    Alzheimer’s disease (AD) presents a significant global health challenge, necessitating accurate and early prediction methods for effective intervention and treatment planning.

  25. A survey on various Alzheimer classification techniques using 3D MRI images: a challenging overview

    ✓ Peer-reviewed alzhub usefulness score 25 out of 100. International Journal of Information and Decision Sciences 2025-01-01 Brain scans and imaging

  26. A survey on various Alzheimer classification techniques using 3D MRI images: a challenging overview

    ✓ Peer-reviewed alzhub usefulness score 25 out of 100. International Journal of Information and Decision Sciences 2025-01-01 Brain scans and imaging

    This survey presents 50 research papers focussed on various techniques in Alzheimer classification techniques using 3D MRI images, and the categorisation of the techniques is made based on the fusion-based, convolutional neural network (CNN)-based, random forest (RF)-based and support vector machine (SVM)-based approaches.

  27. Agentic artificial intelligence in cognitive screening: A translational roadmap for dementia care

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Journal of Alzheimer s Disease Reports 2025-01-01 Digital health tools

    Conventional dementia screening tools, whether paper tests or static artificial intelligence (AI) models, capture only a snapshot of cognition and need to be adminstered periodically.

  28. Alzheimer's Disease Neuroimaging Initiative: Two decades of pioneering Alzheimer's disease research and future directions

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Alzheimer s & Dementia 2025-01-01 Treatments

    This special issue of Alzheimer's & Dementia celebrates the accomplishments of the Alzheimer's Disease Neuroimaging Initiative (ADNI) project as it approaches its 20th anniversary in 2024, supported by funding from the National Institute on Aging.

  29. Deep Learning-Based Framework for Predicting Mild Cognitive Impairment Progression in Neurology Using Longitudinal MRI

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. IEEE Access 2025-01-01 Mild cognitive impairment

    Alzheimer’s disease (AD), a leading neurodegenerative disorder, progresses from an intermediary stage known as Mild Cognitive Impairment (MCI), characterized by measurable cognitive decline with retained functional independence.

  30. Diagnosis of Alzheimer’s Disease and Frontotemporal Dementia From Electroencephalography Signals

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2025-01-01 Getting a diagnosis

    Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most burdensome neurodegenerative disorders in older populations as they pose significant challenges because of subtle cognitive decline in the initial stages.

  31. Exploring the Effectiveness of Machine Learning and Deep Learning Techniques for EEG Signal Classification in Neurological Disorders

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. IEEE Access 2025-01-01 Digital health tools

    Neurological disorders are among the leading causes of both physical and cognitive disabilities worldwide, affecting approximately 15% of the global population.

  32. Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer’s disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain Communications 2025-01-01 Getting a diagnosis

    Finally, we showed that the MD-MRI-derived astrogliosis biomarker is the only MRI measure capable of predicting cognitive state.

  33. Self-Attention Augmented Wasserstein Generative Adversarial Network-based Detection of Brain Alzheimer Disease Using MRI

    ✓ Peer-reviewed alzhub usefulness score 28 out of 100. International Research Journal of Multidisciplinary Scope 2025-01-01 Brain scans and imaging

    Alzheimer’s disease (AD) is a progressive neurological condition that leads to dementia.

  34. Tablet-based cognitive assessment in a multisite study of early-onset AD: association with pen-and-paper tests and PET measures of amyloid and tau

    ⚠ Conference abstract — not peer-reviewed alzhub usefulness score 16 out of 100. Alzheimer's & Dementia (AAIC 2025 conference abstract) 2025 Getting a diagnosis

    Researchers tested whether a tablet-based cognitive test (TabCAT) could substitute for traditional paper-and-pencil memory tests in people with early-onset Alzheimer's. Scores on the tablet's attention/executive tasks correlated strongly (above 0.7) with standard tests like the MMSE and MoCA, and one subtest could distinguish people with amyloid plaques from those without with good accuracy (AUC 0.82).

  35. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Nature communications 2024-12-02 Digital health tools

    Portable, low-field magnetic resonance imaging (LF-MRI) of the brain may facilitate point-of-care assessment of patients with Alzheimer's disease (AD) in settings where conventional MRI cannot.

  36. Argentina-Alzheimer's Disease Neuroimaging Initiative: pioneering Alzheimer's Research in Latin America and its Implications for Regional Advancement

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024-10-06 Down syndrome and Alzheimer's

    The Alzheimer's Disease Neuroimaging Initiative (ADNI) has fostered collaboration among researchers around the world, catalyzing innovation and accelerating progress in the field.

  37. Refractory Status Epilepticus in a Patient With Aducanumab-Induced Amyloid-Related Imaging Abnormalities

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neurology 2024-08-09 Drug development

    The patient was participating in an extended open-label trial of aducanumab when she was admitted to hospital for focal seizures and ARIA in 2 noncontiguous regions of the left frontal and occipital lobes.

  38. Spatial extent as a sensitive amyloid-PET metric in preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024-07-10 Biomarkers

    These findings indicate EXT may be more sensitive to Aβ's role in preclinical AD than level and improve targeting of individuals for AD prevention trials.

  39. Remote and unsupervised digital memory assessments can reliably detect cognitive impairment in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024-06-12 Digital health tools

    Our results demonstrate that unsupervised digital memory assessments might be used for diagnosis and prognosis in Alzheimer's disease, potentially in combination with plasma biomarkers.

  40. A multimodal machine learning model for predicting dementia conversion in Alzheimer’s disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Scientific Reports 2024-05-29 Health systems and care delivery

    Alzheimer's disease (AD) accounts for 60-70% of the population with dementia.

  41. Neuroinflammation in dementia: A meta-analysis of PET imaging studies

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Medicine 2024-05-01 Inflammation and the immune system

    This study summarizes the existing literature on TSPO expression in specific regions of the brain in patients with dementia, and also provides some preliminary evidence on the possible association between neuroinflammation and dementia.

  42. Quantitative Brain Amyloid PET

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2024-05-01 Biomarkers

    Since the development of amyloid tracers for PET imaging, there has been interest in quantifying amyloid burden in the brains of patients with Alzheimer disease.

  43. Artificial Intelligence Assistive Software Tool for Automated Detection and Quantification of Amyloid-Related Imaging Abnormalities

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. JAMA network open 2024-02-05 Drug development

    ARIA monitoring is important to inform treatment dosing decisions and might be improved through assistive software.

  44. Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neurology 2024-02-05 Tau biomarkers

    Alzheimer disease (AD) is primarily associated with accumulations of amyloid plaques and tau tangles in gray matter, however, it is now acknowledged that neuroinflammation, particularly in white matter (WM), significantly contributes to the development and progression of AD.

  45. Machine Learning Models of Polygenic Risk for Enhanced Prediction of Alzheimer Disease Endophenotypes

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurology. Genetics 2024-01-10 Biomarkers

    We found that ML-PRS approaches improved upon standard PRS for prediction of AD endophenotypes, partly related to improved accounting for nonlinear effects of genetic susceptibility alleles.

  46. A Comprehensive, Community‐Engaged Recruitment Strategy to Increase Minority Representation in New IDEAS – an Amyloid Imaging Study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer s & Dementia 2023-12-01 Health systems and care delivery

    To ensure diversity, we developed a comprehensive recruitment strategy using a diverse, culturally‐trained staff that includes : • Identifying Dementia Specialists experienced recruiting minorities • Embedding high‐impact community engagement in select regions • Increasing capacity of specialists and PET facilities to engage minorities • Increasing pipeline of referrals to Dementia Specialists • Creating a culturally‐informed awareness campaign Result New IDEAS has enrolled 4,524 participants including 954 (21.1%) Black/African American, and 842 (18.6%) Hispanic/Latinx.

  47. It is imperative to recognize and mitigate persistent disparities in the COVID‐19 pandemic, particularly pertaining to participation in long‐COVID research.

  48. Amyloid-related Imaging Abnormalities in Alzheimer Disease Treated with Anti-Amyloid-β Therapy

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Radiographics : a review publication of the Radiological Society of North America, Inc 2023-09-01 Brain scans and imaging

    Alzheimer disease (AD) is the most common form of dementia worldwide.

  49. Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. Cell 2023-09-01 Brain tissue and pathology

    Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the molecular and cellular mechanisms underlying cognitive impairment remain poorly understood.

  50. Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2023-08-10 Digital health tools

    The literature has several methodological limitations including lack of sufficient algorithm development descriptions and standard definitions.

From across this tag

8 of the 838 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts