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Home › Research › Topic

Amyloid, tau and blood-test diagnosis

5,209 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Download bibliography of all 5,209 studies, highest score first: BibTeX (.bib) · RIS (.ris)

Highest usefulness score first. Studies without a score come last.

  1. The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer disease and associated disorders 2020-01-01 Inflammation and the immune system

    Increased levels of inflammatory markers were not associated with faster progression as measured by the annual change on the CDR-SB or MMSE score.

    Why it matters

    Researchers measured C-reactive protein and 14 other inflammation markers in the blood of 242 Norwegian memory clinic patients with amnestic mild cognitive impairment or Alzheimer's dementia, then followed them for 2 years. Higher inflammation markers did not predict faster decline on standard memory and dementia rating scales. This suggests these blood inflammation markers may not be useful for forecasting how quickly the disease will progress.

  2. Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Saudi journal of biological sciences 2019-12-26 Disease mechanisms

    The incidence of Alzheimer's disease (AD) has risen exponentially worldwide over the past decade.

  3. Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's research & therapy 2019-12-05 Tau biomarkers

    Determination of β-amyloid (Aβ) positivity and likelihood of underlying Alzheimer's disease (AD) relies on dichotomous biomarker cut-off values.

    Why it matters

    This study explored which cerebrospinal fluid biomarkers and other characteristics, including modifiable vascular factors, predict progression to dementia in memory clinic patients with mild cognitive impairment whose amyloid level was in the normal range. It is about prognosis and risk factors, not about a treatment or cure.

  4. Functional Connectivity between the Resting-State Olfactory Network and the Hippocampus in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain sciences 2019-11-25 Long-term cohort studies

    Olfactory impairment is associated with prodromal Alzheimer's disease (AD) and is a risk factor for the development of dementia.

    Why it matters

    This study examined functional connectivity between the olfactory network and the hippocampus, based on the idea that this connection may be impaired in early Alzheimer's disease. It is about understanding brain changes, not treating, curing, or preventing the disease.

  5. Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2019-10-14 End-of-life care

    Ageing is an inevitable fundamental process for people and is their greatest risk factor for neurodegenerative disease.

  6. Diet therapy for the treatment of Alzheimer's disease in view of traditional Persian medicine: A review

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Iranian journal of basic medical sciences 2019-10-01 Prevention trials

    Alzheimer's disease (AD) is a neurodegenerative disease and the leading cause of dementia worldwide.

  7. The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2019-09-06 Prevention trials

    Nowadays, Alzheimer's disease (AD) is a severe sociological and clinical problem.

  8. Liver Dysfunction as a Novel Player in Alzheimer's Progression: Looking Outside the Brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2019-07-17 Disease mechanisms

    Alzheimer's disease (AD) afflicts an estimated 20 million people worldwide and is the fourth-leading cause of death in the developed world.

  9. The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrients 2019-07-10 Prevention trials

    The prevalence of degenerative diseases has risen in western countries.

  10. P1‐243: BIOMARKER‐GUIDED STRATIFICATION APPROACH OF THE CLINICAL CONTINUUM OF ALZHEIMER'S DISEASE USING UNSUPERVISED CLUSTERING METHODS

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer s & Dementia 2019-07-01 Risk factors

    We found 5 distinct clusters of subjects (N=38, N=16, N=24, N=14, N=21) with a composition statistically independent from that obtained using available clinical diagnostic criteria (each cluster included all phenotypical groups).

    Why it matters

    Using clustering, this study found five groups of people across the Alzheimer's clinical continuum whose biomarker profiles did not match standard clinical diagnostic categories. One group had an increased neuroinflammation biomarker, suggesting those individuals might be candidates for trials targeting neuroinflammation.

  11. Mediterranean and MIND Diets Containing Olive Biophenols Reduces the Prevalence of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2019-06-07 Prevention trials

    The risk of Alzheimer's disease (AD) increases with nonmodifiable conditions including age and lack of effective efficacious pharmacotherapy.

  12. Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Current nutrition reports 2019-06-01 Prevention trials

    Nutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer's disease (AD) and progression of neurodegeneration.

  13. The Effectiveness of Vitamin E Treatment in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2019-02-18 Clinical safety

    Vitamin E was proposed as treatment for Alzheimer's disease many years ago.

  14. Neuroinflammation and fractalkine signaling in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroinflammation 2019-02-11 Disease mechanisms

    Alzheimer's disease (AD) is a progressive, neurodegenerative disorder, and the most common form of dementia.

  15. The Importance of the Validation of M/EEG With Current Biomarkers in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in human neuroscience 2019-02-05 Disease mechanisms

    Current biomarkers used in research and in clinical practice in Alzheimer's Disease (AD) are the analysis of cerebral spinal fluid (CSF) to detect levels of Aβ42 and phosphorylated-tau, amyloid and FDG-PET, and MRI volumetry.

  16. Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. BMC neuroscience 2018-10-17 Vascular contributions

    Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences.

  17. Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in genetics 2018-09-24 Long-term cohort studies

    Alzheimer's disease (AD) is the most common cause of dementia.

    Why it matters

    This study performed genome-wide association analyses for cerebrospinal fluid and clinical traits in the ADNI cohort. It identified several Alzheimer's disease-related genetic variants and suggested that immune response contributes to Alzheimer's disease development.

  18. HIV Neuroinfection and Alzheimer's Disease: Similarities and Potential Links?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular neuroscience 2018-09-11 Disease mechanisms

    Environmental factors such as chemicals, stress and pathogens are now widely believed to play important roles in the onset of some brain diseases, as they are associated with neuronal impairment and acute or chronic inflammation.

  19. The association between "Brain-Age Score" (BAS) and traditional neuropsychological screening tools in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain and behavior 2018-06-22 Long-term cohort studies

    We present the Brain-Age Score (BAS) as a magnetic resonance imaging (MRI)-based index for Alzheimer's disease (AD).

    Why it matters

    This study developed an MRI-based Brain-Age Score and compared it with traditional screening tools for Alzheimer's disease. It is a diagnostic index and does not provide a treatment, cure, or prevention.

  20. Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell death & disease 2018-06-07 Inflammation and the immune system

    Alzheimer's disease (AD) is the most common cause of dementia in the elderly.

  21. Blood Ammonia as a Possible Etiological Agent for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrients 2018-05-04 Prevention trials

    Alzheimer’s disease (AD), characterized by cognitive decline and devastating neurodegeneration, is the most common age-related dementia.

  22. Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neural regeneration research 2018-04-01 Disease mechanisms

    The most prevalent form of dementia in the elderly is Alzheimer's disease.

  23. [O1–04–03]: NEIGHBORHOOD SOCIOECONOMIC CONTEXTUAL DISADVANTAGE, BASELINE COGNITION AND ALZHEIMER's DISEASE BIOMARKERS IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION (WRAP) STUDY

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer s & Dementia 2017-07-01 Risk factors

    Neighborhood disadvantage is associated with education, health behaviors and mortality.

    Why it matters

    This study found that higher neighborhood disadvantage was linked to worse baseline cognitive performance, especially in the most disadvantaged neighborhood decile. It is early data on social context and cognition, not about treating, curing or preventing Alzheimer's disease.

  24. Alzheimer's disease, dementia, and stem cell therapy

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Stem cell research & therapy 2017-05-12 Disease mechanisms

    Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time.

  25. Synergistic interaction between amyloid and tau predicts the progression to dementia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-12-23 Clinical safety

    The present results support that progression to AD dementia is driven by the synergistic rather than a mere additive effect between Aβ and p-tau proteins.

From across this topic

10 of the 5,172 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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