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Home › Research › Topic

Amyloid, tau and blood-test diagnosis

5,209 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Download bibliography of all 5,209 studies, highest score first: BibTeX (.bib) · RIS (.ris)

Highest usefulness score first. Studies without a score come last.

  1. Glial cell dysregulation: a new perspective on Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurotoxicity research 2007-12-01 Risk genes beyond APOE

    Alzheimer disease (AD) is a major cause of dementia.

    Why it matters

    This review discusses glial cell dysregulation and inflammation in Alzheimer's disease, noting it is still unclear whether inflammation is a cause or a consequence of neurodegeneration. It does not report any treatment, cure or prevention.

  2. Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Antioxidants & redox signaling 2006-11-01 Disease mechanisms

    Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and extracellular senile plaques.

  3. REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Sleep 2006-10-01 Disease mechanisms

    Study objective To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects.

  4. Age-dependent axonal degeneration in an Alzheimer mouse model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2006-09-11 Disease mechanisms

    Some neurodegenerative diseases including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) exhibit prominent defects in axonal transport.

  5. Update on hypertension and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurological research 2006-09-01 Vascular contributions

    Several studies report that blood pressure is increased in victims of Alzheimer's disease (AD) decades before the onset of the disease.

  6. Telemedicine, dementia and Down syndrome: implications for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2006-07-01 Down syndrome and Alzheimer's

    This study supports the need for formal reliability and validity studies of TM preparatory to the consideration of this modality for use in clinical trials for AD.

    Why it matters

    This study found that it is feasible to diagnose dementia of the Alzheimer type in people with Down syndrome using telemedicine, which could help those who live far from major medical centers. The authors call for formal reliability and validity studies of telemedicine before it is considered for wider use.

  7. Mitoenergetic failure in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. American journal of physiology. Cell physiology 2006-06-28 Disease mechanisms

    Brain cells are highly energy dependent for maintaining ion homeostasis during high metabolic activity.

  8. Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2006-06-19 Hippocampus size on brain scans

    The concept of amnestic mild cognitive impairment (MCI) describes older people who show a decline predominantly in memory function, but who do not meet criteria for dementia.

  9. Efficacy of language assessment in Alzheimer's disease: comparing in-person examination and telemedicine

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Clinical interventions in aging 2006-01-01 Digital health tools

    Telemedicine can improve access to speech and language evaluation services which is relevant to both dementia and other neurological diseases of the elderly.

    Why it matters

    In ten patients with mild Alzheimer's disease, language test scores were not significantly different when tests were done by telemedicine compared with in-person testing. This is about how assessment is delivered, not about treating, curing or preventing the disease.

  10. Current pharmacotherapy for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of medicine 2006-01-01 Disease mechanisms

    Alzheimer's disease (AD) is an age-related neurodegenerative disease that affects approximately 4.5 million people in the United States.

  11. The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current Alzheimer research 2005-10-01 Disease mechanisms

    Neuronal loss is associated with Alzheimer's disease (AD).

  12. Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current drug targets. CNS and neurological disorders 2005-08-01 Disease mechanisms

    The characteristic hallmarks of Alzheimer's disease (AD), the most common form of dementia in the elderly, include senile plaques, mainly composed of beta-amyloid (Abeta) peptide, neurofibrillary tangles and selective synaptic and neuronal loss in brain regions involved in learning and memory.

  13. Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2005-04-01 Hippocampus size on brain scans

    Structural deformity of the hippocampus is characteristic of individuals with very mild and mild forms of dementia of the Alzheimer type (DAT).

  14. Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pharmacological research 2005-01-01 Vascular contributions

    Memantine is also reported to have beneficial effects in other CNS disorders viz., Parkinson's disease (PD), stroke, epilepsy, CNS trauma, amyotrophic lateral sclerosis (ALS), drug dependence and chronic pain.

  15. Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropathology : official journal of the Japanese Society of Neuropathology 2004-12-01 Disease mechanisms

    Argyrophilic grain disease (AgD) is a late-onset dementia morphologically characterized by the presence of abundant spindle-shaped argyrophilic grains (ArG) in neuronal processes and coiled bodies in oligodendrocytes.

  16. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004-09-01 Hippocampus size on brain scans

    Application of magnetic resonance imaging (MRI) techniques reveals that human brain aging varies across cortical regions.

  17. Role for glyoxalase I in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2004-05-05 Disease mechanisms

    P301L mutant tau transgenic mice develop neurofibrillary tangles, a histopathologic hallmark of Alzheimer's disease and frontotemporal dementia (FTDP-17).

  18. Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2002-06-01 Disease mechanisms

    Alzheimer's disease (AD) brain is characterized by excess deposition of amyloid beta-peptide (Abeta), particularly the 42-amino acid peptide [Abeta(1-42)] and by extensive oxidative stress.

  19. Involvement of Maillard reactions in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurotoxicity research 2002-05-01 Disease mechanisms

    Maillard reactions have been explored by food chemists for many years.

  20. Beta-amyloid, neuronal death and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current molecular medicine 2001-12-01 Disease mechanisms

    Alzheimer's disease (AD) is a common neurodegenerative disease that affects cognitive function in the elderly.

  21. Immunological aspects of microglia: relevance to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurochemistry international 2001-11-01 Inflammation and the immune system

    Alzheimer's disease (AD) is a progressive dementing neurologic illness, and the most frequent cause of dementia in the elderly.

  22. MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2001-09-01 Hippocampus size on brain scans

    With high resolution, quantitative magnetic resonance imaging (MRI) techniques, it is now possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD).

  23. Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2001-05-01 Disease mechanisms

    To explore the hypothesis that alterations in ethanolamine plasmalogen may be directly related to the severity of dementia in Alzheimer's disease (AD), we performed a systematic examination of plasmalogen content in cellular membranes of gray and white matter from different regions of human subjects with a spectrum of AD clinical dementia ratings (CDR) using electrospray ionization mass spectrometry (ESI/MS).

  24. Cell death or synaptic loss in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 2000-12-01 Disease mechanisms

    It is an erroneous but common assumption that loss of neuronal perikarya causes the cognitive change in Alzheimer disease.

  25. Review: modulating factors in amyloid-beta fibril formation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of structural biology 2000-06-01 Clinical safety

    Amyloid formation is a key pathological feature of Alzheimer's disease and is considered to be a major contributing factor to neurodegeneration and clinical dementia.

From across this topic

10 of the 5,172 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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