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Default Mode Network Connectivity in Alzheimers Disease
Elif Yıldırım, Ezgi Soncu Büyükişcan. Turk psikiyatri dergisi = Turkish journal of psychiatry, 2019
Topic: Brain imaging, connectivity and assessment
Studies generally indicate a progressive impairment in DMN connectivity during the course of AD. It has been also stated that DMN subsystems show differential connectivity patterns in the preclinical and prodromal stages of AD. There is also evidence suggesting that impairment in DMN connectivity could be associated with different connectivity patterns in other networks. Furthermore, findings point towards a relationship between DMN and AD-related neuropathology and genetic risk factors. It may be proposed that AD is a generalized disconnection syndrome that causes functional impairments in resting state networks, particularly in DMN. In addition to this, AD-related functional connectivity changes observed in preclinical cases and risk carriers might be a potential bio-marker for AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Yıldırım, E., & Büyükişcan, E. S. (2019). Default Mode Network Connectivity in Alzheimers Disease. Turk psikiyatri dergisi = Turkish journal of psychiatry.
Vancouver
Yıldırım E, Büyükişcan ES. Default Mode Network Connectivity in Alzheimers Disease. Turk psikiyatri dergisi = Turkish journal of psychiatry. 2019. PMID: 32594490.
BibTeX
@article{yldrm2019-32594490,
author = {Yıldırım, Elif and Büyükişcan, Ezgi Soncu},
title = {{Default Mode Network Connectivity in Alzheimers Disease}},
journal = {Turk psikiyatri dergisi = Turkish journal of psychiatry},
year = {2019},
pmid = {32594490}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Studies generally indicate a progressive impairment in DMN connectivity during the course of AD.
- It has been also stated that DMN subsystems show differential connectivity patterns in the preclinical and prodromal stages of AD.
- There is also evidence suggesting that impairment in DMN connectivity could be associated with different connectivity patterns in other networks.
- Furthermore, findings point towards a relationship between DMN and AD-related neuropathology and genetic risk factors.
- It may be proposed that AD is a generalized disconnection syndrome that causes functional impairments in resting state networks, particularly in DMN.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Turk psikiyatri dergisi = Turkish journal of psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32594490) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
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