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59/100

✓ Peer-reviewed alzhub usefulness score 59 out of 100. Mild cognitive impairment

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

BackgroundAlzheimer's disease (AD) accounts for the majority of dementia-related disorders among aging populations. Given the irreversible nature of AD, early detection of cognitive impairment is critical for improving prognosis and facilitating timely interventions before individuals meet the clinical criteria for AD.ObjectiveThe objective of this review is to provide a comprehensive summary of recent advances in task-based electroencephalography (EEG), such as using attention and inhibitory control tasks, which has recently emerged as a promising non-invasive biomarker for assessing neurophysiological alterations associated with AD and mild cognitive impairment (MCI).MethodsThis systematic review evaluates the efficacy of task-based EEG biomarkers in distinguishing cognitively impaired individuals from those without impairment. A comprehensive literature search was conducted across PubMed, Semantic Scholar, and SpringerLink databases for studies published between 2017 and 2024.ResultsFindings indicate consistent neurophysiological alterations in MCI and AD, particularly reductions in event-related potential amplitudes and prolonged latencies, with P3 abnormalities observed in about half of the studies assessing selective attention and inhibitory control. Similarly, a comparable number of studies using working memory tasks report disrupted functional connectivity patterns, increased low-frequency oscillations (delta and theta activity), and reduced fast oscillations (alpha and beta activity).ConclusionsThese EEG-based indices demonstrate potential as objective biomarkers for detecting neural alterations associated with cognitive decline in both AD and preclinical dementia stages. Further research is needed to standardize EEG protocols and validate their clinical utility for early diagnosis and disease progression monitoring.

What this study adds

Evidence grade: High

This is a pooled review. This review found that task-based EEG shows consistent brain wave changes in people with mild cognitive impairment and Alzheimer's disease, such as reduced event-related potential amplitudes and disrupted connectivity. These EEG measures may help detect cognitive impairment early, but the review does not evaluate any treatment or cure.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Tripanpitak, K., Wolf, A., Kapitonova, M., Umeda, S., Ball, T., & Otake, M. (2026). Biomarkers for Alzheimer's disease and mild cognitive impairment: Recent advances in task-based EEG. Journal of Alzheimer s Disease. https://doi.org/10.1177/13872877251413700

Vancouver

Tripanpitak K, Wolf A, Kapitonova M, Umeda S, Ball T, Otake M. Biomarkers for Alzheimer's disease and mild cognitive impairment: Recent advances in task-based EEG. Journal of Alzheimer s Disease. 2026. doi:10.1177/13872877251413700. PMID: 41636372.

BibTeX

@article{tripanpitak2026-41636372,
  author  = {Tripanpitak, Kornkanok and Wolf, Alexandra and Kapitonova, Maryna and Umeda, Satoshi and Ball, Tonio and Otake, Mihoko},
  title   = {{Biomarkers for Alzheimer's disease and mild cognitive impairment: Recent advances in task-based EEG}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1177/13872877251413700},
  pmid    = {41636372},
  url     = {https://doi.org/10.1177/13872877251413700}
}

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How to read this study

Design: this is a pooled review. It combines earlier studies, so it is only as good as the studies it pools. Check how many were included, whether they were similar enough to combine, and whether the authors report inconsistency between them.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded high. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. High means the abstract mentions a randomized design, a meta-analysis or a systematic review. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Given the irreversible nature of AD, early detection of cognitive impairment is critical for improving prognosis and facilitating timely interventions before individuals meet the clinical criteria for AD.ObjectiveThe objective of this review is to provide a comprehensive summary of recent advances in task-based electroencephalography (EEG), such as using attention and inhibitory control tasks, which has recently emerged as a promising non-invasive biomarker for assessing neurophysiological alterations associated with AD and mild cognitive impairment (MCI).MethodsThis systematic review evaluates the efficacy of task-based EEG biomarkers in distinguishing cognitively impaired individuals from those without impairment.
Similarly, a comparable number of studies using working memory tasks report disrupted functional connectivity patterns, increased low-frequency oscillations (delta and theta activity), and reduced fast oscillations (alpha and beta activity).ConclusionsThese EEG-based indices demonstrate potential as objective biomarkers for detecting neural alterations associated with cognitive decline in both AD and preclinical dementia stages.

Why it matters

This review found that task-based EEG shows consistent brain wave changes in people with mild cognitive impairment and Alzheimer's disease, such as reduced event-related potential amplitudes and disrupted connectivity. These EEG measures may help detect cognitive impairment early, but the review does not evaluate any treatment or cure.

Study details

Study designsystematic review
Evidence strengthHigh

How this study scored 59/100

Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease)
Journal's citation record	2 / 4	Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29)
Study design	12 / 12	A systematic review of all the studies on the question
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	A review of other studies — randomization is not credited here
Times cited	2 / 7	Cited 6 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.0 citations a year over 2 year(s) since 2026
Impact for its field and year	5 / 6	Cited 28.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Mihoko Otake: h-index 15 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Freiburg: institution h-index 1,068 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 5 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41636372)
Free to read	2 / 2	Free to read
Total	59 / 100	—

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