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57/100

✓ Peer-reviewed alzhub usefulness score 57 out of 100. Risk factors

Topic: Brain proteins, microglia and lab models

A total of 110 participants (mean [SD] age, 67.9 [4.6] years; 68 female [61.8%]) were randomized to the experimental group (n = 55) and the sham group (n = 55) and included in the intention-to-treat analysis. At 6 weeks after the intervention, compared with the sham group, the experimental group showed a lower PSQI score (between-group mean difference, -3.1 [95% CI, -4.2 to -2.1]; P < .001) and a higher MoCA score (between-group mean difference, 1.4 [95% CI, 0.7-2.1]; P < .001). The per-protocol dataset analyses and 12-week follow-up showed similar results. The generalized estimated equation model revealed an interaction effect between the PSQI score (mean difference, -2.1 [95% CI, -3.1 to -0.1]; P < .001) and the MoCA total score (mean difference, 0.9 [95% CI, 0.1-1.6]; P = .01). There were 7 nonserious, unrelated adverse events (experimental group: 2; sham group: 5) with no significant difference between the 2 groups. Conclusions and Relevance: In this randomized clinical trial, the findings suggest that 1-Hz rTMS enhanced the clinical benefits of tai chi chuan in improving sleep quality and cognitive function among older adults with sleep disorders and MCI, which may be related to alterations in neural plasticity. These findings provide novel data on nonpharmacologic strategies for the rehabilitation of sleep disorders and may delay or even prevent MCI. Trial Registration: Chinese Clinical Trial Registry Identifier: ChiCTR2200063274.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Liu, Z., Zhang, L., Bai, L., Guo, Z., Gao, J., Lin, Y., et al. (2025). Repetitive Transcranial Magnetic Stimulation and Tai Chi Chuan for Older Adults With Sleep Disorders and Mild Cognitive Impairment. JAMA Network Open. https://doi.org/10.1001/jamanetworkopen.2024.54307

Vancouver

Liu Z, Zhang L, Bai L, Guo Z, Gao J, Lin Y, et al. Repetitive Transcranial Magnetic Stimulation and Tai Chi Chuan for Older Adults With Sleep Disorders and Mild Cognitive Impairment. JAMA Network Open. 2025. doi:10.1001/jamanetworkopen.2024.54307. PMID: 39792383.

BibTeX

@article{liu2025-39792383,
  author  = {Liu, Zhizhen and Zhang, Lin and Bai, Linxin and Guo, Zhenxing and Gao, Jiahui and Lin, Yongsheng and Zhou, Yongjin and Lai, Jinghui and others},
  title   = {{Repetitive Transcranial Magnetic Stimulation and Tai Chi Chuan for Older Adults With Sleep Disorders and Mild Cognitive Impairment}},
  journal = {JAMA Network Open},
  year    = {2025},
  doi     = {10.1001/jamanetworkopen.2024.54307},
  pmid    = {39792383},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.54307}
}

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Key findings

A total of 110 participants (mean [SD] age, 67.9 [4.6] years; 68 female [61.8%]) were randomized to the experimental group (n = 55) and the sham group (n = 55) and included in the intention-to-treat analysis.
At 6 weeks after the intervention, compared with the sham group, the experimental group showed a lower PSQI score (between-group mean difference, -3.1 [95% CI, -4.2 to -2.1]; P < .001) and a higher MoCA score (between-group mean difference, 1.4 [95% CI, 0.7-2.1]; P < .001).
The per-protocol dataset analyses and 12-week follow-up showed similar results.
The generalized estimated equation model revealed an interaction effect between the PSQI score (mean difference, -2.1 [95% CI, -3.1 to -0.1]; P < .001) and the MoCA total score (mean difference, 0.9 [95% CI, 0.1-1.6]; P = .01).
There were 7 nonserious, unrelated adverse events (experimental group: 2; sham group: 5) with no significant difference between the 2 groups.

Why it matters

In this trial of 110 older adults with sleep disorders and mild cognitive impairment, combining repetitive transcranial magnetic stimulation with tai chi improved sleep quality and cognitive test scores compared to a sham group. These findings suggest a non-drug approach may help delay or prevent mild cognitive impairment, though longer-term benefits are not yet known.

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Study details

Participants55
Effect size61.8%
Evidence strengthHigh

How this study scored 57/100

Published in a leading specialty journal. Scored zero for study design because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA Network Open)
Journal's citation record	2 / 4	JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	55 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	1 / 2	Randomized (as stated in the record)
Times cited	3 / 7	Cited 30 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.0 citations a year over 3 year(s) since 2025
Impact for its field and year	4 / 6	Cited 9.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	2 / 4	Cited 30 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Lidian Chen: h-index 54 (OpenAlex, whole career)
Institution's track record	0 / 3	Shenzhen University: institution h-index 530 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39792383)
Free to read	2 / 2	Free to read
Total	57 / 100	—

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