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Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults
May A Beydoun, Nicole Noren Hooten, Hind A Beydoun, Jordan Weiss, Ana I Maldonado, Leslie I Katzel, Christos Davatzikos, Rao P Gullapalli et al.. Neurobiology of aging, 2023-05-02
Topic: Brain imaging, connectivity and assessment
Elevated plasma neurofilament light chain (NfL) is associated with dementia though underlying mechanisms remain unknown. We examined cross-sectional relationships of time-dependent plasma NfL with selected brain structural magnetic resonance imaging (sMRI) prognostic markers of dementia. The sample was drawn from the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study, selecting participants with complete v1 (2004-2009) and v2 (2009-2013) plasma NfL exposure and ancillary sMRI data at vscan (2011-2015, n = 179, mean v1 to vscan time: 5.4 years). Multivariable-adjusted linear regression models were conducted, overall, by sex, and race, correcting for multiple testing with q-values. NfL(v1) was associated with larger WMLV (both Loge transformed), after 5-6 years' follow-up, overall (β = +2.131 ± 0.660, b = +0.29, p = 0.001, and q = 0.0029) and among females. NfLv2 was linked to a 125 mm3 lower left hippocampal volume (p = 0.004 and q = 0.015) in reduced models, mainly among males, as was observed for annualized longitudinal change in NfL (δNfLbayes). Among African American adults, NfLv1 was inversely related to total, gray and white matter volumes. Plasma NfL may reflect future brain pathologies in middle-aged adults.
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APA 7th
Beydoun, M. A., Hooten, N. N., Beydoun, H. A., Weiss, J., Maldonado, A. I., Katzel, L. I., et al. (2023). Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2023.04.013
Vancouver
Beydoun MA, Hooten NN, Beydoun HA, Weiss J, Maldonado AI, Katzel LI, et al. Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults. Neurobiology of aging. 2023. doi:10.1016/j.neurobiolaging.2023.04.013. PMID: 37257406.
BibTeX
@article{beydoun2023-37257406,
author = {Beydoun, May A and Hooten, Nicole Noren and Beydoun, Hind A and Weiss, Jordan and Maldonado, Ana I and Katzel, Leslie I and Davatzikos, Christos and Gullapalli, Rao P and others},
title = {{Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults}},
journal = {Neurobiology of aging},
year = {2023},
doi = {10.1016/j.neurobiolaging.2023.04.013},
pmid = {37257406},
url = {https://doi.org/10.1016/j.neurobiolaging.2023.04.013}
}
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Key findings
- Elevated plasma neurofilament light chain (NfL) is associated with dementia though underlying mechanisms remain unknown.
- Multivariable-adjusted linear regression models were conducted, overall, by sex, and race, correcting for multiple testing with q-values.
- NfL(v1) was associated with larger WMLV (both Loge transformed), after 5-6 years' follow-up, overall (β = +2.131 ± 0.660, b = +0.29, p = 0.001, and q = 0.0029) and among females.
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Study details
- Study designcross-sectional
- Participants179
- Evidence strengthModerate
How this study scored 61/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 34 of the 56 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 179 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37257406) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 34 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 34 of the 56 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
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