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Cardiovascular risk factors and cerebral atrophy in a middle-aged cohort
Knopman DS, Mosley TH, Catellier DJ, Sharrett AR, Atherosclerosis Risk in Communities (ARIC) Study.. Neurology, 2005-09-01
Topic: Risk, prevention and care in population studies
Background Because cardiovascular (CV) risk factors have been associated with declines in cognitive functions and late life dementia, CV risk factors should also be associated with brain atrophy. Objective To study the association of CV risk factors with ventricular size (VS) and sulcal size (SS) in the middle-aged and young-elderly Atherosclerosis Risk in Communities (ARIC) Study cohort. Methods Cerebral MRI was performed on 1,812 individuals (aged 50 to 73 [mean 62.3] years, 60% women, 50% African American) with no history of stroke or TIA from the ARIC cohort at study sites in Forsyth County, NC, and Jackson, MS.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Knopman, D. S., Mosley, T. H., Catellier, D. J., & Sharrett, A. R. (2005). Cardiovascular risk factors and cerebral atrophy in a middle-aged cohort. Neurology. https://doi.org/10.1212/01.wnl.0000176074.09733.a8
Vancouver
Knopman DS, Mosley TH, Catellier DJ, Sharrett AR. Cardiovascular risk factors and cerebral atrophy in a middle-aged cohort. Neurology. 2005. doi:10.1212/01.wnl.0000176074.09733.a8. PMID: 16186527.
BibTeX
@article{knopman2005-16186527,
author = {Knopman, D. S. and Mosley, T. H. and Catellier, D. J. and Sharrett, A. R.},
title = {{Cardiovascular risk factors and cerebral atrophy in a middle-aged cohort}},
journal = {Neurology},
year = {2005},
doi = {10.1212/01.wnl.0000176074.09733.a8},
pmid = {16186527},
url = {https://doi.org/10.1212/01.wnl.0000176074.09733.a8}
}
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Key findings
- Objective To study the association of CV risk factors with ventricular size (VS) and sulcal size (SS) in the middle-aged and young-elderly Atherosclerosis Risk in Communities (ARIC) Study cohort.
- Methods Cerebral MRI was performed on 1,812 individuals (aged 50 to 73 [mean 62.3] years, 60% women, 50% African American) with no history of stroke or TIA from the ARIC cohort at study sites in Forsyth County, NC, and Jackson, MS.
- Neuroradiologists rated VS and SS using a semiquantitative, 10-point scale by visual comparison with a standardized reference atlas.
- CV risk factors were assessed approximately 6 years prior to the MR scan.
Why it matters
This study looked at whether cardiovascular risk factors are associated with brain atrophy in middle-aged and young-elderly adults. It reports associations only and does not show that treating these risk factors prevents Alzheimer's disease.
Study details
- Participants1,812
- Effect sizeOR = 1.63; OR = 1.07
- Evidence strengthModerate
How this study scored 57/100
Published in a leading specialty journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 3 / 4 | 1,812 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 113 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.9 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 3 / 6 | Cited 4.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author A. Richey Sharrett: h-index 59 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16186527) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
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