Topic: Brain proteins, microglia and lab models
Abstract Alterations of resting state intrinsic functional networks have been associated with neurodegenerative diseases even before the onset of cognitive symptoms. Power and sensitivity analyses were completed to assess the robustness of the results. None of the genetically proxied functional network features were significantly associated with neurodegenerative outcomes (adjusted P value >0.05), despite sufficient calculated power. The genetically proxied DMN connectivity was associated with the risk of depression (P = 0.024), supporting the validity of the genetic instruments. Sensitivity analyses were supportive of the main results. Overall, the results do not support a causal role for the tested associations.
Key findings
- Abstract Alterations of resting state intrinsic functional networks have been associated with neurodegenerative diseases even before the onset of cognitive symptoms.
- Power and sensitivity analyses were completed to assess the robustness of the results.
- None of the genetically proxied functional network features were significantly associated with neurodegenerative outcomes (adjusted P value >0.05), despite sufficient calculated power.
- The genetically proxied DMN connectivity was associated with the risk of depression (P = 0.024), supporting the validity of the genetic instruments.
- Sensitivity analyses were supportive of the main results.
Why it matters
This genetic analysis found no evidence that resting-state functional network features cause neurodegenerative diseases. The results do not support a causal role for the tested associations.
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Study details
- Participants47
- Evidence strengthLow
How this study scored 43/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain Communications) |
| Journal's citation record | 0 / 4 | Brain Communications: journal h-index 67 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 47 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Emily Joy Rogalski: h-index 59 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40103583) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
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Read the original
- DOI: 10.1093/braincomms/fcaf098
- PubMed: 40103583
- Original source →
- Free full text: Brain Communications →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Nassan, M. M., Daghlas, I., Diamond, B. R., Martersteck, A., & Rogalski, E. J. (2025). The causal association between resting state intrinsic functional networks and neurodegeneration. Brain Communications. https://doi.org/10.1093/braincomms/fcaf098
Vancouver
Nassan MM, Daghlas I, Diamond BR, Martersteck A, Rogalski EJ. The causal association between resting state intrinsic functional networks and neurodegeneration. Brain Communications. 2025. doi:10.1093/braincomms/fcaf098. PMID: 40103583.
BibTeX
@article{nassan2025-40103583,
author = {Nassan, Malik M. and Daghlas, Iyas and Diamond, Bram R and Martersteck, Adam and Rogalski, Emily Joy},
title = {{The causal association between resting state intrinsic functional networks and neurodegeneration}},
journal = {Brain Communications},
year = {2025},
doi = {10.1093/braincomms/fcaf098},
pmid = {40103583},
url = {https://doi.org/10.1093/braincomms/fcaf098}
}
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