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Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study
Girard TD, Thompson JL, Pandharipande PP, Brummel NE, Jackson JC, Patel MB, Hughes CG, Chandrasekhar R et al.. The Lancet. Respiratory medicine, 2018-03-01
Topic: Risk, prevention and care in population studies
Background Delirium during critical illness results from numerous insults, which might be interconnected and yet individually contribute to long-term cognitive impairment. Interpretation Our findings suggest that clinicians should consider sedative-associated, hypoxic, and septic delirium, which often co-occur, as distinct indicators of acute brain injury and seek to identify all potential risk factors that may impact on long-term cognitive impairment, especially those that are iatrogenic and potentially modifiable such as sedation.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Girard, T. D., Thompson, J. L., Pandharipande, P. P., Brummel, N. E., Jackson, J. C., Patel, M. B., et al. (2018). Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. The Lancet. Respiratory medicine. https://doi.org/10.1016/s2213-2600(18)30062-6
Vancouver
Girard TD, Thompson JL, Pandharipande PP, Brummel NE, Jackson JC, Patel MB, et al. Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. The Lancet. Respiratory medicine. 2018. doi:10.1016/s2213-2600(18)30062-6. PMID: 29508705.
BibTeX
@article{girard2018-29508705,
author = {Girard, T. D. and Thompson, J. L. and Pandharipande, P. P. and Brummel, N. E. and Jackson, J. C. and Patel, M. B. and Hughes, C. G. and Chandrasekhar, R. and others},
title = {{Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study}},
journal = {The Lancet. Respiratory medicine},
year = {2018},
doi = {10.1016/s2213-2600(18)30062-6},
pmid = {29508705},
url = {https://doi.org/10.1016/s2213-2600(18)30062-6}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Background Delirium during critical illness results from numerous insults, which might be interconnected and yet individually contribute to long-term cognitive impairment.
- Interpretation Our findings suggest that clinicians should consider sedative-associated, hypoxic, and septic delirium, which often co-occur, as distinct indicators of acute brain injury and seek to identify all potential risk factors that may impact on long-term cognitive impairment, especially those that are iatrogenic and potentially modifiable such as sedation.
Why it matters
In a prospective cohort of critically ill patients, the authors concluded that sedative-associated, hypoxic and septic delirium — which "often co-occur" — should each be treated as a distinct indicator of acute brain injury linked to later long-term cognitive impairment. They single out sedation as a risk factor that is "iatrogenic and potentially modifiable", but the study is observational, tested no treatment, and does not address Alzheimer's disease directly.
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Study details
- Study designcohort study
- Participants1,048
- Evidence strengthModerate
How this study scored 70/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Lancet. Respiratory medicine) |
| Journal's citation record | 3 / 4 | The Lancet Respiratory Medicine: journal h-index 253 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,048 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 438 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 43.8 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 5 / 6 | Cited 33.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 147 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Eugene Wesley Ely: h-index 135 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 12 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29508705) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 70 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s2213-2600(18)30062-6
- PubMed: 29508705
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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