Cerebrovascular co-pathology and… | 2025

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48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Lewy body dementia

Topic: Brain proteins, microglia and lab models

Lewy body patients showed a significantly higher degree of WMSA in the external capsule cholinergic pathway despite no significant differences in global WMSA compared to controls. Furthermore, higher CHIPS scores, Fazekas scale and tractography mean diffusivity were associated with more pronounced frontal atrophy in Lewy body patients but not in controls. In conclusion, cholinergic WMSA were more pronounced in Lewy body patients compared to healthy controls, independently of global WMSA. Our findings indicate that cerebrovascular disease-related disruptions in cholinergic white matter may be linked to frontal atrophy in Lewy body patients.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Jerele, C., Tzortzakakis, A., Němý, M., Rennie, A., Arranz, J., Montal, V., et al. (2025). Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum. Brain Communications. https://doi.org/10.1093/braincomms/fcaf173

Vancouver

Jerele C, Tzortzakakis A, Němý M, Rennie A, Arranz J, Montal V, et al. Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum. Brain Communications. 2025. doi:10.1093/braincomms/fcaf173. PMID: 40391186.

BibTeX

@article{jerele2025-40391186,
  author  = {Jerele, Cene and Tzortzakakis, Antonios and Němý, Milan and Rennie, Anna and Arranz, Javier and Montal, Víctor and Bejanin, Alexandre and Aarsland, Dag and others},
  title   = {{Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf173},
  pmid    = {40391186},
  url     = {https://doi.org/10.1093/braincomms/fcaf173}
}

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Key findings

Lewy body patients showed a significantly higher degree of WMSA in the external capsule cholinergic pathway despite no significant differences in global WMSA compared to controls.
Furthermore, higher CHIPS scores, Fazekas scale and tractography mean diffusivity were associated with more pronounced frontal atrophy in Lewy body patients but not in controls.
In conclusion, cholinergic WMSA were more pronounced in Lewy body patients compared to healthy controls, independently of global WMSA.
Our findings indicate that cerebrovascular disease-related disruptions in cholinergic white matter may be linked to frontal atrophy in Lewy body patients.

Why it matters

In Lewy body patients, white matter hyperintensities were greater in the external capsule cholinergic pathway than in controls even though global white matter hyperintensities did not differ, and these measures were linked to more frontal atrophy. This suggests cerebrovascular disruption of cholinergic pathways may relate to frontal atrophy but does not test any treatment, cure or prevention.

Study details

Participants82
Evidence strengthModerate

How this study scored 48/100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Brain Communications)
Journal's citation record	0 / 4	Brain Communications: journal h-index 67 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	82 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 6 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.0 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	1 / 4	Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Daniel Ferreira: h-index 41 (OpenAlex, whole career)
Institution's track record	1 / 3	Karolinska Institutet: institution h-index 1,477 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 12 institution(s) in 6 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40391186)
Free to read	2 / 2	Free to read
Total	48 / 100	—

What each of these 20 components measures, and what this score is not →

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