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Magnetoencephalographic analysis of cortical activity in Alzheimer's disease: a pilot study
Berendse HW, Verbunt JP, Scheltens P, van Dijk BW, Jonkman EJ.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2000-04-01
Topic: Amyloid, tau and blood-test diagnosis
Objectives In the present study, MEG was used to analyze spectral power and reference-free coherence in patients with probable Alzheimer's disease (AD). Methods Sixty-one channel MEG was recorded in 5 AD patients and 5 age-matched controls at rest with eyes open and eyes closed, as well as during the performance of two different mental tasks. Artefact-free epochs were selected for the analysis of power and coherence values in each of 5 4-Hz wide frequency bands ranging from 2 to 22 Hz. Results In AD patients, the absolute low frequency magnetic power was significantly and rather diffusely increased relative to controls with a fronto-central maximum. High frequency power values were significantly decreased over the occipital and temporal areas. Reactivity to eye-opening and mental tasks was reduced in the patient group. Relative to controls, a general decrease of MEG coherence values, including all frequencies analyzed, was found in AD patients. Conclusions These observations confirm the pattern of changes in spectral power and reactivity known from EEG studies and suggest that coherence decreases in AD patients are widespread and include frequencies outside the alpha band.
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APA 7th
Berendse, H. W., Verbunt, J. P., Scheltens, P., van Dijk, B. W., & Jonkman, E. J. (2000). Magnetoencephalographic analysis of cortical activity in Alzheimer's disease: a pilot study. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. https://doi.org/10.1016/s1388-2457(99)00309-0
Vancouver
Berendse HW, Verbunt JP, Scheltens P, van Dijk BW, Jonkman EJ. Magnetoencephalographic analysis of cortical activity in Alzheimer's disease: a pilot study. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2000. doi:10.1016/s1388-2457(99)00309-0. PMID: 10727911.
BibTeX
@article{berendse2000-10727911,
author = {Berendse, H. W. and Verbunt, J. P. and Scheltens, P. and van Dijk, B. W. and Jonkman, E. J.},
title = {{Magnetoencephalographic analysis of cortical activity in Alzheimer's disease: a pilot study}},
journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
year = {2000},
doi = {10.1016/s1388-2457(99)00309-0},
pmid = {10727911},
url = {https://doi.org/10.1016/s1388-2457(99)00309-0}
}
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Key findings
- Results In AD patients, the absolute low frequency magnetic power was significantly and rather diffusely increased relative to controls with a fronto-central maximum.
- High frequency power values were significantly decreased over the occipital and temporal areas.
- Conclusions These observations confirm the pattern of changes in spectral power and reactivity known from EEG studies and suggest that coherence decreases in AD patients are widespread and include frequencies outside the alpha band.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2000 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 10727911) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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