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46/100

✓ Peer-reviewed alzhub usefulness score 46 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

Purpose To apply a recently developed native-space (or native-surface) method to compare resting functional magnetic resonance (MR) imaging correlations (functional connectivity) measured in patients with Parkinson-related dementia (PRD) to those measured in cognitively unimpaired, age-matched control subjects with or without Parkinson disease (PD). Materials and methods The study was approved by the institutional review board and complied with HIPAA regulations. Participants included cognitively unimpaired elderly individuals (n = 19), cognitively unimpaired patients with PD (n = 19), and patients with PRD (n = 18). Resting functional MR data were assessed by calculating correlation coefficients between blood oxygen level-dependent time series of a seed region and of other regions of interest selected a priori. Two seeds were used: a medial parietal region that contributes to the default network affected in Alzheimer disease and the caudate, which is affected by loss of dopaminergic inputs in PD. Correlation analyses were performed in the native space of individual subjects to avoid confounds from transformation to an average brain. Two-sample t tests were applied to data from each native-surface region of interest, and vertex-wise comparisons were made by using two-sample t tests at each vertex on the group surface; statistical results were corrected for multiple comparisons. Cortical thickness and striatal volumes were also compared across groups for the regions of interest. Results Corticostriatal functional correlations were decreased in PRD patients relative to elderly control subjects in bilateral prefrontal regions; largest difference was observed in the right caudal middle frontal region (r = 0.48 in PRD patients and 0.81 in elderly control subjects, uncorrected P = .001). Conversely, there was no significant difference across groups in the strength of default-network correlations. There was also no significant difference across groups in cortical thickness or striatal volume. Conclusion PRD was associated with selective disruption of corticostriatal resting functional MR imaging correlations, which suggests that resting functional MR imaging analyzed in subject-native space may be a useful biomarker in this disease. Additionally, at least in the present cohort, this technique was more sensitive to PRD changes than was quantitative structural MR imaging.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Seibert, T. M., Murphy, E. A., Kaestner, E. J., & Brewer, J. B. (2012). Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging. Radiology. https://doi.org/10.1148/radiol.12111280

Vancouver

Seibert TM, Murphy EA, Kaestner EJ, Brewer JB. Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging. Radiology. 2012. doi:10.1148/radiol.12111280. PMID: 22371611.

BibTeX

@article{seibert2012-22371611,
  author  = {Seibert, T. M. and Murphy, E. A. and Kaestner, E. J. and Brewer, J. B.},
  title   = {{Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging}},
  journal = {Radiology},
  year    = {2012},
  doi     = {10.1148/radiol.12111280},
  pmid    = {22371611},
  url     = {https://doi.org/10.1148/radiol.12111280}
}

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Key findings

Two-sample t tests were applied to data from each native-surface region of interest, and vertex-wise comparisons were made by using two-sample t tests at each vertex on the group surface; statistical results were corrected for multiple comparisons.
Results Corticostriatal functional correlations were decreased in PRD patients relative to elderly control subjects in bilateral prefrontal regions; largest difference was observed in the right caudal middle frontal region (r = 0.48 in PRD patients and 0.81 in elderly control subjects, uncorrected P = .001).
Conversely, there was no significant difference across groups in the strength of default-network correlations.
There was also no significant difference across groups in cortical thickness or striatal volume.
Conclusion PRD was associated with selective disruption of corticostriatal resting functional MR imaging correlations, which suggests that resting functional MR imaging analyzed in subject-native space may be a useful biomarker in this disease.

Why it matters

This small imaging study compared resting brain connectivity in people with Parkinson-related dementia, Parkinson disease without dementia, and healthy controls. It is about understanding brain changes in Parkinson-related dementia, not about treating, curing or preventing Alzheimer's disease.

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Study details

Participants19
Evidence strengthModerate

How this study scored 46/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Radiology)
Journal's citation record	3 / 4	Radiology: journal h-index 431 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2012 — within 20 year(s) of the newest study here
Sample size	1 / 4	19 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 80 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	5.0 citations a year over 16 year(s) since 2012
Impact for its field and year	3 / 6	Cited 4.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 5 other studies in this library
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author James B. Brewer: h-index 47 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California San Diego: institution h-index 1,852 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 22371611)
Free to read	0 / 2	Behind a paywall — scores zero
Total	46 / 100	—

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