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Neuropathologic Changes in People With Essential Tremor With Dementia
Ethan Wainman, Diane S. Berry, Nora C. Hernandez, T. Sloane Guy, Stephanie Cosentino, Phyllis L. Faust, Elan D. Louis. Neurology, 2025-10-29
Topic: Risk, prevention and care in population studies
= 0.009). Other neuropathologies were similar across cognitive groups. Our neuropathologic description of ET-dementia shows that, in this sample of 40 participants with ET-dementia, Alzheimer pathology is the prime driver of marked cognitive impairment in ET. Further studies are needed to refine our understanding of the nature of tau aggregation in ET and the extent to which this is similar to or diverges from that seen in AD. One implication of the current finding, which is a more direct link between ET and AD, is that this opens the door to blood-based biomarker testing in individuals with ET who are experiencing cognitive difficulties.
Key findings
- Other neuropathologies were similar across cognitive groups.
- Our neuropathologic description of ET-dementia shows that, in this sample of 40 participants with ET-dementia, Alzheimer pathology is the prime driver of marked cognitive impairment in ET.
- Further studies are needed to refine our understanding of the nature of tau aggregation in ET and the extent to which this is similar to or diverges from that seen in AD.
- One implication of the current finding, which is a more direct link between ET and AD, is that this opens the door to blood-based biomarker testing in individuals with ET who are experiencing cognitive difficulties.
Why it matters
In 40 participants with essential tremor and dementia, Alzheimer pathology was the prime driver of marked cognitive impairment. The authors say further studies are needed to understand the nature of tau aggregation in essential tremor and note this finding opens the door to blood-based biomarker testing in people with essential tremor who have cognitive difficulties.
Study details
- Study designcohort study
- Participants40
- Evidence strengthModerate
How this study scored 58/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 40 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Elan D. Louis: h-index 87 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Columbia University: institution h-index 1,824 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41160795) |
| Free to read | 2 / 2 | Free to read |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1212/wnl.0000000000214310
- PubMed: 41160795
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Wainman, E., Berry, D. S., Hernandez, N. C., Guy, T. S., Cosentino, S., Faust, P. L., et al. (2025). Neuropathologic Changes in People With Essential Tremor With Dementia. Neurology. https://doi.org/10.1212/wnl.0000000000214310
Vancouver
Wainman E, Berry DS, Hernandez NC, Guy TS, Cosentino S, Faust PL, et al. Neuropathologic Changes in People With Essential Tremor With Dementia. Neurology. 2025. doi:10.1212/wnl.0000000000214310. PMID: 41160795.
BibTeX
@article{wainman2025-41160795,
author = {Wainman, Ethan and Berry, Diane S. and Hernandez, Nora C. and Guy, T. Sloane and Cosentino, Stephanie and Faust, Phyllis L. and Louis, Elan D.},
title = {{Neuropathologic Changes in People With Essential Tremor With Dementia}},
journal = {Neurology},
year = {2025},
doi = {10.1212/wnl.0000000000214310},
pmid = {41160795},
url = {https://doi.org/10.1212/wnl.0000000000214310}
}
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