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Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia
Nilton Custodio, Gregory L. Brown, Belén Custodio, Rosa Montesinos, Milagros Nuñez-Huanca, Pamela Bartolo, Zadith Yauri, Katherine Agüero et al.. Alzheimer s & Dementia, 2025-12-01
Topic: Amyloid, tau and blood-test diagnosis
Functional impairment increased progressively from normal cognition to dementia. Alzheimer's disease (AD) and frontotemporal dementia (FTD) groups showed significantly greater total PFAQ scores compared to controls and mild cognitive impairment (MCI). Distinct profiles of impairment emerged: AD was more associated with memory-dependent tasks, while FTD showed disproportionate deficits in executive and social activities. Functional abilities are differentially impacted in AD and FTD within the Peruvian population. Our findings highlight the importance of item-level functional evaluation to support early detection and subtype differentiation of dementia in underserved regions. HIGHLIGHTS: We characterized and compared functional abilities among Peruvian older adults with normal cognition and neurodegenerative disease in different stages. PFAQ scores were analyzed across dementia stages in a Peruvian population. Functional abilities were differentially impacted in Peruvian participants with AD compared to FTD. AD was more associated with memory-dependent tasks, while FTD showed disproportional deficits in executive and social activities.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Custodio, N., Brown, G. L., Custodio, B., Montesinos, R., Nuñez-Huanca, M., Bartolo, P., et al. (2025). Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70979
Vancouver
Custodio N, Brown GL, Custodio B, Montesinos R, Nuñez-Huanca M, Bartolo P, et al. Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70979. PMID: 41400005.
BibTeX
@article{custodio2025-41400005,
author = {Custodio, Nilton and Brown, Gregory L. and Custodio, Belén and Montesinos, Rosa and Nuñez-Huanca, Milagros and Bartolo, Pamela and Yauri, Zadith and Agüero, Katherine and others},
title = {{Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70979},
pmid = {41400005},
url = {https://doi.org/10.1002/alz.70979}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Functional impairment increased progressively from normal cognition to dementia.
- Alzheimer's disease (AD) and frontotemporal dementia (FTD) groups showed significantly greater total PFAQ scores compared to controls and mild cognitive impairment (MCI).
- Distinct profiles of impairment emerged: AD was more associated with memory-dependent tasks, while FTD showed disproportionate deficits in executive and social activities.
- Functional abilities are differentially impacted in AD and FTD within the Peruvian population.
- Our findings highlight the importance of item-level functional evaluation to support early detection and subtype differentiation of dementia in underserved regions.
Why it matters
This cross-sectional study found that functional impairment increased progressively from normal cognition to dementia, with Alzheimer's disease more associated with memory-dependent tasks and frontotemporal dementia showing disproportionate deficits in executive and social activities. It is about functional profiles, not about treating, curing or preventing dementia.
Study details
- Study designcross-sectional
- Participants1,445
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,445 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Agustín M. Ibáñez: h-index 81 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 5 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41400005) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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