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Autonomic Dysfunction in Patients With Dementia With Lewy Bodies and Its Relationship With Nigrostriatal Denervation
Chiara Giuseppina Bonomi, Alessandro Martorana, Caterina Motta, Chiara Serafini, Agostino Chiaravalloti, Benedetta Lauretti, Orazio Schillaci, Nicola Biagio Mercuri et al.. Neurology, 2025-03-20
Topic: Brain proteins, microglia and lab models
= 0.029). Despite the absence of overt nOH, patients with DLB show covert dysautonomia encompassing adrenergic, parasympathetic, and sudomotor dysfunction, highlighting the importance of standardized autonomic evaluation. Patients with normal DaT-SPECT exhibited greater peripheral autonomic impairment, reflected by lower HG responses, suggesting diverse α-synuclein pathology trajectories within DLB. Further research is needed to explore autonomic nervous system dysfunctions across different DLB subtypes and stages.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Bonomi, C. G., Martorana, A., Motta, C., Serafini, C., Chiaravalloti, A., Lauretti, B., et al. (2025). Autonomic Dysfunction in Patients With Dementia With Lewy Bodies and Its Relationship With Nigrostriatal Denervation. Neurology. https://doi.org/10.1212/wnl.0000000000213463
Vancouver
Bonomi CG, Martorana A, Motta C, Serafini C, Chiaravalloti A, Lauretti B, et al. Autonomic Dysfunction in Patients With Dementia With Lewy Bodies and Its Relationship With Nigrostriatal Denervation. Neurology. 2025. doi:10.1212/wnl.0000000000213463. PMID: 40112273.
BibTeX
@article{bonomi2025-40112273,
author = {Bonomi, Chiara Giuseppina and Martorana, Alessandro and Motta, Caterina and Serafini, Chiara and Chiaravalloti, Agostino and Lauretti, Benedetta and Schillaci, Orazio and Mercuri, Nicola Biagio and others},
title = {{Autonomic Dysfunction in Patients With Dementia With Lewy Bodies and Its Relationship With Nigrostriatal Denervation}},
journal = {Neurology},
year = {2025},
doi = {10.1212/wnl.0000000000213463},
pmid = {40112273},
url = {https://doi.org/10.1212/wnl.0000000000213463}
}
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Key findings
- Despite the absence of overt nOH, patients with DLB show covert dysautonomia encompassing adrenergic, parasympathetic, and sudomotor dysfunction, highlighting the importance of standardized autonomic evaluation.
- Patients with normal DaT-SPECT exhibited greater peripheral autonomic impairment, reflected by lower HG responses, suggesting diverse α-synuclein pathology trajectories within DLB.
- Further research is needed to explore autonomic nervous system dysfunctions across different DLB subtypes and stages.
Why it matters
This cohort study found that patients with dementia with Lewy bodies show covert dysautonomia affecting adrenergic, parasympathetic and sudomotor function even without overt orthostatic hypotension, and that those with normal DaT-SPECT had greater peripheral autonomic impairment. The authors call for further research into autonomic dysfunction across dementia with Lewy bodies subtypes and stages, and no treatment, cure or prevention is reported.
Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 50/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 6 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 3.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Camilla Rocchi: h-index 13 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Rome Tor Vergata: institution h-index 778 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40112273) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
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