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Effects of certain pre-analytical factors on the performance of plasma phospho-tau217
Bali D, Hansson O, Janelidze S.. Alzheimer's research & therapy, 2024-02-08
Topic: Brain proteins, microglia and lab models
Results In the whole cohort (combining Aβ + and Aβ - participants), we found significant correlations between plasma p-tau217 and both CSF p-tau217 (R range, 0.614-0.717, p < 0.001) and CSF Aβ42/Aβ40 (Spearman R range , - 0.515 to - 0.652, p < 0.001) for each of the four tested conditions. Correlations between plasma and CSF p-tau217 were also significant for all conditions in the Aβ + group (R range , 0.506-0.579, p < 0.001). However, in this Aβ + subgroup, correlations with CSF Aβ42/Aβ40 were only significant for centrifuged samples (thawed at RT, R = - 0.394, p = 0.010; thawed on ice, R = - 0.406; p = 0.007). In Aβ - participants, correlations between plasma and CSF p-tau217 were again significant only for centrifuged samples (thawed at RT, R = 0.394, p = 0.007; thawed on ice, R = 0.334; p = 0.022), with no correlations seen between plasma p-tau217 and CSF Aβ42/Aβ40 for any of the conditions. Conclusion Centrifugation improved the performance of plasma p-tau217, but thawing temperatures and up to three freeze-thaw cycles did not have a significant impact. These results may inform the future development of standardized sample-handling protocols for AD biomarkers.
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APA 7th
Bali, D., Hansson, O., & Janelidze, S. (2024). Effects of certain pre-analytical factors on the performance of plasma phospho-tau217. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-024-01391-1
Vancouver
Bali D, Hansson O, Janelidze S. Effects of certain pre-analytical factors on the performance of plasma phospho-tau217. Alzheimer's research & therapy. 2024. doi:10.1186/s13195-024-01391-1. PMID: 38331843.
BibTeX
@article{bali2024-38331843,
author = {Bali, D. and Hansson, O. and Janelidze, S.},
title = {{Effects of certain pre-analytical factors on the performance of plasma phospho-tau217}},
journal = {Alzheimer's research \& therapy},
year = {2024},
doi = {10.1186/s13195-024-01391-1},
pmid = {38331843},
url = {https://doi.org/10.1186/s13195-024-01391-1}
}
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Key findings
- Results In the whole cohort (combining Aβ + and Aβ - participants), we found significant correlations between plasma p-tau217 and both CSF p-tau217 (R range, 0.614-0.717, p < 0.001) and CSF Aβ42/Aβ40 (Spearman R range , - 0.515 to - 0.652, p < 0.001) for each of the four tested conditions.
- Correlations between plasma and CSF p-tau217 were also significant for all conditions in the Aβ + group (R range , 0.506-0.579, p < 0.001).
- However, in this Aβ + subgroup, correlations with CSF Aβ42/Aβ40 were only significant for centrifuged samples (thawed at RT, R = - 0.394, p = 0.010; thawed on ice, R = - 0.406; p = 0.007).
- In Aβ - participants, correlations between plasma and CSF p-tau217 were again significant only for centrifuged samples (thawed at RT, R = 0.394, p = 0.007; thawed on ice, R = 0.334; p = 0.022), with no correlations seen between plasma p-tau217 and CSF Aβ42/Aβ40 for any of the conditions.
- Conclusion Centrifugation improved the performance of plasma p-tau217, but thawing temperatures and up to three freeze-thaw cycles did not have a significant impact.
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Study details
- Participants50
- Evidence strengthModerate
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 32 of the 58 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's research & therapy) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 50 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38331843) |
| Free to read | 2 / 2 | Free to read |
| Points | 32 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 32 of the 58 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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