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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Brain scans and imaging

Topic: Brain proteins, microglia and lab models

Aβ + CN individuals performed worse than Aβ-CN participants in the SCBC while the SOC only distinguished Aβ − CN from MCI participants. The SCBC performance was predicted by tau burden in the EC after adjusting for Aβ, white matter hypointensities, inferior temporal cortex (ITC) tau burden, age, sex, and education. The SCBC was more sensitive than the PACC5 in identifying CN individuals with a positive tau-PET scan. Impaired visual short-term memory binding performance was evident from the preclinical stage of sporadic AD and related to tau pathology in the EC, suggesting that SCBC performance could detect early tau pathology in the EC among CN individuals.

Key findings

Aβ + CN individuals performed worse than Aβ-CN participants in the SCBC while the SOC only distinguished Aβ − CN from MCI participants.
The SCBC performance was predicted by tau burden in the EC after adjusting for Aβ, white matter hypointensities, inferior temporal cortex (ITC) tau burden, age, sex, and education.
The SCBC was more sensitive than the PACC5 in identifying CN individuals with a positive tau-PET scan.
Impaired visual short-term memory binding performance was evident from the preclinical stage of sporadic AD and related to tau pathology in the EC, suggesting that SCBC performance could detect early tau pathology in the EC among CN individuals.

Why it matters

This study found that a short-term memory binding test was worse in cognitively normal people with amyloid and was linked to tau in the entorhinal cortex, detecting early tau pathology better than a standard cognitive test. It is an observational study about early detection and does not test any treatment, cure, or prevention.

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Study details

Evidence strengthLow

How this study scored 42/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of the International Neuropsychological Society)
Journal's citation record	2 / 4	Journal of the International Neuropsychological Society: journal h-index 176 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 5 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.7 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Bernard Jimmy Hanseeuw: h-index 48 (OpenAlex, whole career)
Institution's track record	3 / 3	Harvard University: institution h-index 3,235 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 7 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40400392)
Free to read	2 / 2	Free to read
Total	42 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Huyghe, L., Quenon, L., Salman, Y., Colmant, L., Gérard, T., Malotaux, V., et al. (2025). Entorhinal tau impairs short-term memory binding in preclinical Alzheimer’s disease. Journal of the International Neuropsychological Society. https://doi.org/10.1017/s1355617725000165

Vancouver

Huyghe L, Quenon L, Salman Y, Colmant L, Gérard T, Malotaux V, et al. Entorhinal tau impairs short-term memory binding in preclinical Alzheimer’s disease. Journal of the International Neuropsychological Society. 2025. doi:10.1017/s1355617725000165. PMID: 40400392.

BibTeX

@article{huyghe2025-40400392,
  author  = {Huyghe, Lara and Quenon, Lisa and Salman, Yasmine and Colmant, Lise and Gérard, Thomas and Malotaux, Vincent and Boyer, Emilien and Dricot, Laurence and others},
  title   = {{Entorhinal tau impairs short-term memory binding in preclinical Alzheimer’s disease}},
  journal = {Journal of the International Neuropsychological Society},
  year    = {2025},
  doi     = {10.1017/s1355617725000165},
  pmid    = {40400392},
  url     = {https://doi.org/10.1017/s1355617725000165}
}

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