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Comparison of plasma and CSF biomarkers across ethnoracial groups in the ADNI
Windon C, Iaccarino L, Mundada N, Allen I, Boxer AL, Byrd D, Rivera-Mindt M, Rabinovici GD et al.. Alzheimer's & dementia (Amsterdam, Netherlands), 2022-05-01
Topic: Risk, prevention and care in population studies
Introduction Ethnoracial differences in cerebrospinal fluid (CSF; amyloid beta 42 [Aβ42], total tau [t-tau], phosphorylated tau 181 [p-tau181], and plasma (p-tau181, neurofilament light [NfL]) biomarkers of Alzheimer's disease (AD) are incompletely understood. Methods We performed cross-sectional analyses with and without adjustment for covariates comparing baseline CSF (Aβ42, t-tau, p-tau181) and plasma (p-tau181, NfL) values in 47 African Americans (AAs) matched to 141 non-Hispanic Whites (NHWs) and 43 Latinos (LAs) matched to 129 NHWs from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Results Unadjusted comparisons revealed no significant differences in plasma or CSF biomarkers between AAs and NHWs. A trend toward a lower CSF t-tau and p-tau181 in LAs compared to NHWs was observed, without significant differences in plasma biomarkers. After adjusting for covariates, there were no significant differences in CSF or plasma biomarkers between AAs and NHWs or between LAs and NHWs. Discussion Plasma and CSF AD biomarkers may perform similarly across diverse populations but future studies in large, diverse cohorts are needed.
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APA 7th
Windon, C., Iaccarino, L., Mundada, N., Allen, I., Boxer, A. L., Byrd, D., et al. (2022). Comparison of plasma and CSF biomarkers across ethnoracial groups in the ADNI. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.12315
Vancouver
Windon C, Iaccarino L, Mundada N, Allen I, Boxer AL, Byrd D, et al. Comparison of plasma and CSF biomarkers across ethnoracial groups in the ADNI. Alzheimer's & dementia (Amsterdam, Netherlands). 2022. doi:10.1002/dad2.12315. PMID: 35510092.
BibTeX
@article{windon2022-35510092,
author = {Windon, C. and Iaccarino, L. and Mundada, N. and Allen, I. and Boxer, A. L. and Byrd, D. and Rivera-Mindt, M. and Rabinovici, G. D. and others},
title = {{Comparison of plasma and CSF biomarkers across ethnoracial groups in the ADNI}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2022},
doi = {10.1002/dad2.12315},
pmid = {35510092},
url = {https://doi.org/10.1002/dad2.12315}
}
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Key findings
- Results Unadjusted comparisons revealed no significant differences in plasma or CSF biomarkers between AAs and NHWs.
- A trend toward a lower CSF t-tau and p-tau181 in LAs compared to NHWs was observed, without significant differences in plasma biomarkers.
- After adjusting for covariates, there were no significant differences in CSF or plasma biomarkers between AAs and NHWs or between LAs and NHWs.
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Study details
- Study designcross-sectional
- Evidence strengthLow
How this study scored 53/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 31 of the 58 points we could judge it on, which is 53 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35510092) |
| Free to read | 2 / 2 | Free to read |
| Points | 31 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 31 of the 58 points we could judge it on is 53 out of 100. |
| Total | 53 / 100 | — |
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