Immunoreactivity of presenilin-1 in human, rat and mouse brain

Topic: Brain proteins, microglia and lab models

Plain-language summary

Monoclonal antibodies (mAbs) D3G6 and C8A5, specific for amino acid residues 160-168 of S182 protein, immunolabeled neurons, ependymal and choroid plexus cells, and myocytes in brain sections from normal subjects and people with Alzheimer disease or Down syndrome and in rats and mice. Oligodendroglia, microglia, and the majority of astrocytes were negative. S182 protein or a fragment of the protein detected with these mAbs is not a constituent of amyloid-beta deposits or tangles.

@article{kim1997-9200512,
  author  = {Kim, K. S. and Wegiel, J. and Sapienza, V. and Chen, J. and Hong, H. and Wisniewski, H. M.},
  title   = {{Immunoreactivity of presenilin-1 in human, rat and mouse brain}},
  journal = {Brain research},
  year    = {1997},
  doi     = {10.1016/s0006-8993(97)00243-6},
  pmid    = {9200512},
  url     = {https://doi.org/10.1016/s0006-8993(97)00243-6}
}

Key findings

• Monoclonal antibodies (mAbs) D3G6 and C8A5, specific for amino acid residues 160-168 of S182 protein, immunolabeled neurons, ependymal and choroid plexus cells, and myocytes in brain sections from normal subjects and people with Alzheimer disease or Down syndrome and in rats and mice.
• Oligodendroglia, microglia, and the majority of astrocytes were negative.
• S182 protein or a fragment of the protein detected with these mAbs is not a constituent of amyloid-beta deposits or tangles.

Why it matters

Antibodies to the presenilin-1 protein labelled neurons and some other cells in brain tissue from normal people and people with Alzheimer's disease or Down syndrome. The protein detected was not part of amyloid-beta deposits or tangles, so this describes where the protein is found rather than any treatment or prevention.

Study details

• Evidence strengthLow

Read the original

• DOI: 10.1016/s0006-8993(97)00243-6
• PubMed: 9200512
• Original source →

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Studies this one cites

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• Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease Nature · 1995-06-01 · usefulness score 64/100 · Genetics
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