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Development of Alzheimer disease in Down syndrome individuals
Miniszek NA.. American journal of mental deficiency, 1983-01-01
Topic: Amyloid, tau and blood-test diagnosis
Results of autopsies have indicated that people with Down syndrome who live longer than 40 years develop the brain pathology of Alzheimer disease, a presenile dementia. Because of their initially low levels of mental functioning, Down syndrome persons' clinical symptoms frequently go undetected until the disease is advanced and deterioration severe. Study of this doubly inflicted population is critical to development of appropriate assessment methods and to the study of the role of genetics in aging. A preliminary investigation of the AAMD Adaptive Behavior Scale (ABS) as a potential diagnostic tool was presented. The ABS clearly differentiated the regressed from the well-functioning Down syndrome individuals, offering promise as a practical assessment device.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Miniszek, N. A. (1983). Development of Alzheimer disease in Down syndrome individuals. American journal of mental deficiency.
Vancouver
Miniszek NA. Development of Alzheimer disease in Down syndrome individuals. American journal of mental deficiency. 1983. PMID: 6219583.
BibTeX
@article{miniszek1983-6219583,
author = {Miniszek, N. A.},
title = {{Development of Alzheimer disease in Down syndrome individuals}},
journal = {American journal of mental deficiency},
year = {1983},
pmid = {6219583}
}
Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results of autopsies have indicated that people with Down syndrome who live longer than 40 years develop the brain pathology of Alzheimer disease, a presenile dementia.
Why it matters
This paper notes that people with Down syndrome who live past 40 develop the brain pathology of Alzheimer disease, and it presents a preliminary test for assessing regression. It does not report any treatment or cure.
Study details
- Evidence strengthLow
How this study scored 34/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, senior author's track record and institution's track record, so those were left out: it earned 30 of the 89 points we could judge it on, which is 34 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American journal of mental deficiency) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1983 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 62 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.4 citations a year over 45 year(s) since 1983 |
| Impact for its field and year | 4 / 6 | Cited 8.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Miniszek Na holds only 1 work(s), too few to judge a track record — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 6219583) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 30 / 89 | Scored on 17 of 20 parts. We have no data for the rest, so they are left out: 30 of the 89 points we could judge it on is 34 out of 100. |
| Total | 34 / 100 | — |
What each of these 20 components measures, and what this score is not →
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