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Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid
Wisniewski T, Golabek A, Matsubara E, Ghiso J, Frangione B.. Biochemical and biophysical research communications, 1993-04-01
Topic: Amyloid, tau and blood-test diagnosis
Apolipoprotein E (apo E) is associated with Alzheimer's beta-amyloid (A beta) in senile plaques. A beta is now known to be a normal soluble peptide (sA beta) found in the cerebrospinal fluid (CSF) and other biological fluids. We have used synthetic A beta peptides bound to affinity membranes in order to determine whether apo E or any other amyloid associated protein will bind to these membranes, when they are bathed in CSF. Under these conditions apo E, as well as another apolipoprotein, apolipoprotein J (Apo J), bound to the membranes. Using ELISA and ligand binding studies, we found a high avidity binding of A beta peptides to apo E. This suggests that apo E, as well as other related proteins may bind not only amyloid A beta but also sA beta. This interaction may be critical in amyloid formation.
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APA 7th
Wisniewski, T., Golabek, A., Matsubara, E., Ghiso, J., & Frangione, B. (1993). Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid. Biochemical and biophysical research communications. https://doi.org/10.1006/bbrc.1993.1423
Vancouver
Wisniewski T, Golabek A, Matsubara E, Ghiso J, Frangione B. Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid. Biochemical and biophysical research communications. 1993. doi:10.1006/bbrc.1993.1423. PMID: 8484748.
BibTeX
@article{wisniewski1993-8484748,
author = {Wisniewski, T. and Golabek, A. and Matsubara, E. and Ghiso, J. and Frangione, B.},
title = {{Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid}},
journal = {Biochemical and biophysical research communications},
year = {1993},
doi = {10.1006/bbrc.1993.1423},
pmid = {8484748},
url = {https://doi.org/10.1006/bbrc.1993.1423}
}
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Key findings
- Apolipoprotein E (apo E) is associated with Alzheimer's beta-amyloid (A beta) in senile plaques.
- Using ELISA and ligand binding studies, we found a high avidity binding of A beta peptides to apo E.
- This suggests that apo E, as well as other related proteins may bind not only amyloid A beta but also sA beta.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biochemical and biophysical research communications) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1993 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 8484748) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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