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66/100

✓ Peer-reviewed alzhub usefulness score 66 out of 100. Down syndrome and Alzheimer's

Topic: Amyloid, tau and blood-test diagnosis

Results There were 132 720 unique adults with Down syndrome from 2011 to 2019: 79 578 (53.2%) were male, 17 090 (11.7%) were non-Hispanic Black, 20 777 (15.7%) were Hispanic, 101 120 (68.8%) were non-Hispanic White, and 47 692 (23.3%) had ever had an Alzheimer dementia diagnosis. The mean (SD) age at onset for the Hispanic group was 54.2 (9.2) years, 52.4 (7.8) years for the American Indian or Alaska Native group, and 52.8 (8.2) years for the mixed race groups compared with 55.0 (7.8) years for the White non-Hispanic group. The mean (SD) age at death was later for the White non-Hispanic group (59.3 [6.8] years) compared with the Hispanic group (58.5 [7.8] years), Native American group (57.8 [7.1] years), and mixed race group (58.2 [7.0] years).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Rubenstein, E., Tewolde, S., Michals, A., Weuve, J., Fortea, J., Fox, M. P., et al. (2024). Alzheimer Dementia Among Individuals With Down Syndrome. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2024.35018

Vancouver

Rubenstein E, Tewolde S, Michals A, Weuve J, Fortea J, Fox MP, et al. Alzheimer Dementia Among Individuals With Down Syndrome. JAMA network open. 2024. doi:10.1001/jamanetworkopen.2024.35018. PMID: 39312235.

BibTeX

@article{rubenstein2024-39312235,
  author  = {Rubenstein, E. and Tewolde, S. and Michals, A. and Weuve, J. and Fortea, J. and Fox, M. P. and Pescador Jimenez, M. and Scott, A. and others},
  title   = {{Alzheimer Dementia Among Individuals With Down Syndrome}},
  journal = {JAMA network open},
  year    = {2024},
  doi     = {10.1001/jamanetworkopen.2024.35018},
  pmid    = {39312235},
  url     = {https://doi.org/10.1001/jamanetworkopen.2024.35018}
}

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Key findings

Results There were 132 720 unique adults with Down syndrome from 2011 to 2019: 79 578 (53.2%) were male, 17 090 (11.7%) were non-Hispanic Black, 20 777 (15.7%) were Hispanic, 101 120 (68.8%) were non-Hispanic White, and 47 692 (23.3%) had ever had an Alzheimer dementia diagnosis.
The mean (SD) age at onset for the Hispanic group was 54.2 (9.2) years, 52.4 (7.8) years for the American Indian or Alaska Native group, and 52.8 (8.2) years for the mixed race groups compared with 55.0 (7.8) years for the White non-Hispanic group.
The mean (SD) age at death was later for the White non-Hispanic group (59.3 [6.8] years) compared with the Hispanic group (58.5 [7.8] years), Native American group (57.8 [7.1] years), and mixed race group (58.2 [7.0] years).

Why it matters

In a cohort of 132,720 adults with Down syndrome from 2011 to 2019, 47,692 had ever had an Alzheimer dementia diagnosis, and mean age at onset and age at death differed across racial and ethnic groups. This is a descriptive study of diagnosis and age patterns and does not test any treatment, cure or prevention.

Study details

Study designcohort study
Participants132
Effect size53.2%; 11.7%; 15.7%
Evidence strengthModerate

How this study scored 66/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA network open)
Journal's citation record	2 / 4	JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2024 — within 3 year(s) of the newest study here
Sample size	2 / 4	132 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 37 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	9.2 citations a year over 4 year(s) since 2024
Impact for its field and year	4 / 6	Cited 14.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 8 other studies in this library
Still being cited	2 / 4	Cited 37 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Brian G. Skotko: h-index 40 (OpenAlex, whole career)
Institution's track record	2 / 3	Massachusetts General Hospital: institution h-index 2,057 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 5 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39312235)
Free to read	2 / 2	Free to read
Total	66 / 100	—

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