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A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two?
Seltzer B, Sherwin I.. Archives of neurology, 1983-03-01
Topic: Risk, prevention and care in population studies
The prevalence of a number of clinical features occurring in patients with early- (before age 65) and late-onset primary degenerative dementia of the Alzheimer type (PDDAT) are compared. The data from a total of 65 patients demonstrated a greater prevalence of language disturbance, a disproportionate number of left-handers, and a much shorter relative survival time in the early-onset group. Taken together with other data, these findings indicate a degree of heterogeneity in the clinical features of patients with PDDAT and suggest a possible heightened selective vulnerability of the left hemisphere in early-onset cases.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Seltzer, B., & Sherwin, I. (1983). A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two? Archives of neurology. https://doi.org/10.1001/archneur.1983.04050030037006
Vancouver
Seltzer B, Sherwin I. A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two? Archives of neurology. 1983. doi:10.1001/archneur.1983.04050030037006. PMID: 6830452.
BibTeX
@article{seltzer1983-6830452,
author = {Seltzer, B. and Sherwin, I.},
title = {{A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two?}},
journal = {Archives of neurology},
year = {1983},
doi = {10.1001/archneur.1983.04050030037006},
pmid = {6830452},
url = {https://doi.org/10.1001/archneur.1983.04050030037006}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The data from a total of 65 patients demonstrated a greater prevalence of language disturbance, a disproportionate number of left-handers, and a much shorter relative survival time in the early-onset group.
- Taken together with other data, these findings indicate a degree of heterogeneity in the clinical features of patients with PDDAT and suggest a possible heightened selective vulnerability of the left hemisphere in early-onset cases.
- We interpret the data as raising the possibility that the current view of PDDAT as a unitary disorder may not be entirely valid.
Why it matters
In 65 patients with Alzheimer-type dementia, those whose symptoms began before age 65 had more language problems, a disproportionate number of left-handers and a much shorter relative survival than those with later onset. The authors read this as a sign that the disease may vary between patients, and they suggest the left side of the brain may be more vulnerable in early-onset cases. Both points are put forward as possibilities rather than proven, and the study reports no treatment, cure or prevention.
Study details
- Participants65
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on institution's track record, so that was left out: it earned 47 of the 97 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | 3 / 4 | Archives of Neurology: journal h-index 353 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1983 — older than 20 years, still counted |
| Sample size | 1 / 4 | 65 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 365 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.1 citations a year over 45 year(s) since 1983 |
| Impact for its field and year | 4 / 6 | Cited 16.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Benjamin Seltzer: h-index 23 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 6830452) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 47 / 97 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 47 of the 97 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
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