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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Tau biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Background Neural autoantibodies are being increasingly detected in conjunction with neurodegenerative dementias such as Alzheimer's disease dementia (AD), yet their significance is not well clarified. In this case report, we report the previously unreported long-lasting persistence of potassium voltage-gated channel subfamily A member 2 (KCNA2) antibodies in biomarker-supported AD. Methods We report on a 77-year-old, male patient evaluated in our outpatient memory clinic of the Department of Psychiatry and Psychotherapy, University Medical Center Göttingen.

Key findings

In this case report, we report the previously unreported long-lasting persistence of potassium voltage-gated channel subfamily A member 2 (KCNA2) antibodies in biomarker-supported AD.
Methods We report on a 77-year-old, male patient evaluated in our outpatient memory clinic of the Department of Psychiatry and Psychotherapy, University Medical Center Göttingen.
Neuropsychological test results and autoantibody testing in serum over a period of 4-5 years is provided.
Report Our patient exhibited mild dementia syndrome and was diagnosed with AD on the basis of a prototypical biomarker profile (reduced Aβ42/40 ratio and elevated p-tau181 protein in cerebrospinal fluid).

Why it matters

This single case report describes long-lasting KCNA2 antibodies in one 77-year-old man with biomarker-supported Alzheimer's disease. As one case report, it cannot show that these antibodies cause, treat, cure or prevent the disease.

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Study details

Study designcase report
Evidence strengthLow

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Behavioural brain research)
Journal's citation record	3 / 4	Behavioural Brain Research: journal h-index 252 (OpenAlex, 2026-10-29)
Study design	0 / 12	Design recorded as “case report”, which our rubric does not rank (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (pubmed indexes it as a clinical or observational study)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Claudia Bartels: h-index 26 (OpenAlex, whole career)
Institution's track record	1 / 3	University of Göttingen: institution h-index 934 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39855473)
Free to read	0 / 2	Behind a paywall — scores zero
Total	41 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Hansen, N., Teegen, B., Hirschel, S., Fox, J., Fitzner, D., Wiltfang, J., et al. (2025). Longitudinally persisting KCNA2-autoantibodies in mild amnestic dementia with Alzheimer´s pathology - Report and literature review. Behavioural brain research. https://doi.org/10.1016/j.bbr.2025.115437

Vancouver

Hansen N, Teegen B, Hirschel S, Fox J, Fitzner D, Wiltfang J, et al. Longitudinally persisting KCNA2-autoantibodies in mild amnestic dementia with Alzheimer´s pathology - Report and literature review. Behavioural brain research. 2025. doi:10.1016/j.bbr.2025.115437. PMID: 39855473.

BibTeX

@article{hansen2025-39855473,
  author  = {Hansen, N. and Teegen, B. and Hirschel, S. and Fox, J. and Fitzner, D. and Wiltfang, J. and Bartels, C.},
  title   = {{Longitudinally persisting KCNA2-autoantibodies in mild amnestic dementia with Alzheimer´s pathology - Report and literature review}},
  journal = {Behavioural brain research},
  year    = {2025},
  doi     = {10.1016/j.bbr.2025.115437},
  pmid    = {39855473},
  url     = {https://doi.org/10.1016/j.bbr.2025.115437}
}

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