27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
Among community-dwelling older adults, reports of shorter sleep duration and poorer sleep quality are associated with greater Aβ burden. 4 key findings →
Design: cross-sectional Participants: 70 Evidence: moderate
Full summary, score breakdown and related studies → Original source
For optimal design of anti-amyloid-β (Aβ) and anti-tau clinical trials, we need to better understand the pathophysiological cascade of Aβ- and tau-related processes. 3 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
We developed a robust algorithm to automatically evaluate retinal fundus image that can identify subjects with high WMH burden. 3 key findings →
Design: cross-sectional Participants: 180 Evidence: low
Full summary, score breakdown and related studies → Original source
The results from this study provide information about a group void in the literature pertaining to activity restriction from fear of falling - community-based seniors receiving home care services. 4 key findings →
Design: cross-sectional Participants: 2,304 Evidence: low
Full summary, score breakdown and related studies → Original source
Many VA nursing home residents have SMI. 1 key finding →
Design: cross-sectional Participants: 9,618 Evidence: low
Full summary, score breakdown and related studies → Original source
GIM services care for a markedly heterogeneous population but the most common conditions were similar across 7 hospitals. 3 key findings →
Design: cross-sectional Participants: 223 Evidence: low
Full summary, score breakdown and related studies → Original source
Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. 4 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
We observed significantly higher serum NfL and GFAP levels in PD patients than in HC (p < 0.001). 5 key findings →
Design: cross-sectional Participants: 140 Evidence: low
Full summary, score breakdown and related studies → Original source
Higher GAP-43 was cross-sectionally related to all AD biomarkers (p-values < 0.0001) and predicted longitudinal reductions in Aβ42 (p < 0.0001). 5 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
Higher body mass index at baseline was correlated with lower levels of plasma phosphorylated tau (p-tau)217, p-tau217 ratio, neurofilament light chain (NfL), glial fibrillary acidic protein, and CLs. 4 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
There was a direct and indirect bidirectional effect through the glial fibrillary acidic protein of WMH on phosphorylated tau 217 concentration, which was associated with neurofilament light chain concentration in the entire sample. 3 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
The participants with PD had significantly weaker FC between the vermis and peristriate visual association cortex compared to controls, and the strength of this FC correlated with visuospatial function and global cognition. 5 key findings →
Design: cross-sectional Participants: 47 Evidence: low
Full summary, score breakdown and related studies → Original source
Compared to controls, returning FTD patients (143 vs. 130 μm, p = 0.005) and the tauopathy subgroup (143 vs. 128 μm, p = 0.03) had thinner outer retinas but similar inner layer thicknesses. 5 key findings →
Design: cross-sectional Participants: 16 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Methylation across all the CpGs strongly correlated with each other. 5 key findings →
Design: cross-sectional Participants: 96 Evidence: moderate
Full summary, score breakdown and related studies → Original source
No association was found between MeSy and prevalent dementia. 5 key findings →
Design: cross-sectional Participants: 236 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Higher CRI scores were associated with better cognition. 5 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
80% of participants were lonely. Loneliness was associated with having contacts in less social network domains, in women but not in men. 5 key findings →
Design: cross-sectional Participants: 181 Evidence: low
Full summary, score breakdown and related studies → Original source
Greater mindfulness was associated with positive outcomes and inversely associated with negative outcomes. 4 key findings →
Design: cross-sectional Participants: 128 Evidence: low
Full summary, score breakdown and related studies → Original source
Yet, the association became not significant after controlling for individual physical function. 4 key findings →
Design: cross-sectional Participants: 199 Evidence: low
Full summary, score breakdown and related studies → Original source
The levels of α-synuclein oligomers and oligomers/total-α-synuclein ratio in CSF were higher in the PD group (n = 32; p < 0.0001, Mann-Whitney U test) compared to the control group (n = 28). 5 key findings →
Design: cross-sectional Participants: 32 Evidence: low
Full summary, score breakdown and related studies → Original source
Social cognitive impairments are consistently reported in schizophrenia and are associated with functional outcome. 3 key findings →
Design: cross-sectional Participants: 50 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Serum GFAP is increased in FTLD, correlates with cognition and GABAergic deficits, and thus shows promise as a biomarker of disease severity in FTLD. 3 key findings →
Design: cross-sectional Participants: 406 Evidence: moderate
Full summary, score breakdown and related studies → Original source
In this Delphi survey study, international experts reached consensus on a range of criteria for referral to specialist palliative care. 1 key finding →
Design: cross-sectional Participants: 60 Evidence: early
Full summary, score breakdown and related studies → Original source Free full text
We selected the cerebellum as a pseudo-reference region based on the immunohistochemical comparison of age-matched PS2APP and WT mice. 2 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Our results reveal a spatial association between the epileptogenic focus and tau deposition, amyloid deposition, and neurodegeneration in early clinical stages of AD. 5 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →