27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
The analytical sample comprised 1481 NCI (76.7% female) and 515 MCI (69.7% female) participants. 5 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
) had a 14% increase in the rate of dementia incidence (HR 1.14, 95% CI 1.06-1.23; P <.001), and each standard deviation (SD) decrease in eBMD was associated with a 49% increase in dementia risk (HR 1.49, 95% CI 1.19-1.86; P <.001). 5 key findings →
Design: cohort study Participants: 131,030 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Despite a well-known inverse association between education and dementia risk, the mediating mechanisms are not well understood. 1 key finding →
Participants: 7,655 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Some 5695 patients were identified and included in the final analysis. 5 key findings →
Design: cohort study Participants: 5,695 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Of the patients, 82.2% were receiving at least one dizziness-associated medication and 71.2% at least one hypotension-associated medication. 5 key findings →
Design: cohort study Participants: 210 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
During the COVID-19 pandemic, home health agencies (HHAs) discharges following acute hospitalizations increased. 1 key finding →
Design: cohort study Participants: 426,766 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Adherence to Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) may lower the risk of dementia by impacting immunity and cholesterol, which are pathways also implicated by genome-wide association studies of Alzheimer’s Dementia (AD). 3 key findings →
Participants: 2,449 Evidence: low
Full summary, score breakdown and related studies → Original source
In this large cohort, heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later. 5 key findings →
Participants: 5,367 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Increasing oily fish intake has been proposed as a strategy for Alzheimer's disease (AD) prevention, but evidence for long-term benefit remains limited. 2 key findings →
Design: cohort Participants: 2,012 Evidence: null result
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Relationship between alcohol drinking and incident dementia remained uncertain. 2 key findings →
Design: cohort Participants: 296,715 Evidence: early
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The results of this study indicate an AD-specific peripheral complement signature associated with disease development, highlighting complement factors as critical immune mediators that link aging and AD. 2 key findings →
Design: cohort Participants: 558 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
We studied the association between mid-life smoking and late-life dementia in the Honolulu Heart Program (1965-1971) and follow-up assessment for dementia (1991-1996) of 3734 Japanese-American men (80% of survivors). 2 key findings →
Evidence: low
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As the population ages due to demographic trends and gains in life expectancy, the incidence and prevalence of dementia increases, and the need to understand the etiology and pathogenesis of dementia becomes ever more urgent. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
There is increasing evidence that hypertension may contribute to the development of dementia. 1 key finding →
Participants: 2,015 Evidence: moderate
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Antioxidants have been hypothesized to protect against Alzheimer's disease, but studies conducted in late life have been inconsistent. 2 key findings →
Participants: 2,459 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Among Swedish women, a high cardiovascular fitness in midlife was associated with a decreased risk of subsequent dementia. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
On average, the risk of dementia seems to increase with the number of episodes in depressive and bipolar affective disorders. 2 key findings →
Participants: 18,726 Evidence: low
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Change in eating behaviour was significantly more common in both of the frontotemporal dementia groups than in Alzheimer's disease. 2 key findings →
Participants: 23 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
We surveyed 1,545 subjects--recruited into the UK Medical Research Council elderly hypertension treatment trial between 1982 and 1987--to detect incident cases of dementia, identifying 50 cases of dementia, including 31 cases of probable or possible Alzheimer's disease (AD). 2 key findings →
Participants: 1,545 Evidence: low
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Adverse childhood events are related to continued vulnerability among older adults, enhancing the impact of chronic stressors. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The gender-specific results for obesity, but not for diabetes, suggests that the underlying mechanisms linking them to cognition may be different. 2 key findings →
Participants: 551 Evidence: low
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Cerebral microbleeds (CMBs) are MRI markers attributed to the most common cerebral angiopathies in the elderly and in patients with dementia: hypertensive and cerebral amyloid angiopathy. 4 key findings →
Participants: 85 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Herpes simplex virus 1 (HSV1) is a neuroinvasive virus capable of entering the brain which makes it a candidate pathogen for increasing risk of dementia. 4 key findings →
Participants: 244 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Additionally, we investigated the relation between cardiac function and MRI markers of subclinical cerebrovascular disease. 4 key findings →
Participants: 3,291 Evidence: low
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Visual impairment and interventions to preserve vision may impact dementia risk. 4 key findings →
Participants: 300,823 Evidence: low
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10 of the 1,130 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →