Delirium is a complex neurocognitive syndrome suspected to be bidirectionally linked to dementia. 4 key findings →
Participants: 551 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Research
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
56/100
Chronic musculoskeletal pain has been linked to dementia; however, chronic pain typically occurs in multiple sites; therefore, this study was to investigate whether greater number of chronic pain sites is associated with a higher risk of dementia and its subtypes. 4 key findings →
Participants: 356,383 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
We examined whether sarcopenia is associated with the occurrence of late-life cognitive impairment. 4 key findings →
Participants: 1,175 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Totally 7499 participants were included in the analysis, representing 40,728,543 community-living older Americans. 5 key findings →
Design: longitudinal study Participants: 7,499 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Among non-Latino Whites, ADI was associated with dementia incidence (most vs. least disadvantaged ADI quintile HR = 1.09, 95% confidence interval [CI] = 1.02-1.15). 4 key findings →
Participants: 18,103 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
This cohort study compares the risk of incident all-cause dementia among people with hearing loss who use vs do not use hearing aids. 1 key finding →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
During follow-up ranging from 1.0 to 22.9 years, 75 patients (29.88%) converted to AD. 5 key findings →
Design: longitudinal study Participants: 75 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
A multivariate analysis was also performed to predict specific risk factors associated with male and female EOAD and LOAD patients. 5 key findings →
Design: cohort study Participants: 6,212 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
56/100
We found no significant difference in dementia incidence over a 20‐year follow‐up period compared with matched TIA‐free controls. 3 key findings →
Design: cohort study Participants: 297 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Compared with those without CMD, those with CMD multimorbidity had an elevated risk of ACD (hazard ratio [HR]: 2.27, 95% confidence interval [95% CI]: 1.95-2.63), AD (HR: 1.49, 95% CI: 1.13-1.97), and VD (HR: 3.70, 95% CI: 2.93-4.69). 5 key findings →
Design: cohort study Participants: 287,748 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
We identified 62 928 patients with OSA and 62 928 in the propensity score-matched comparison cohort (76% male, median age 52 years). 5 key findings →
Design: cohort study Participants: 928 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Each 1-unit increase in cumulative score was associated with a 3%-8% higher dementia hazard across cohorts. 5 key findings →
Design: cohort study Participants: 23,305 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Individuals with both physical frailty and depression had the highest risk of dementia. 5 key findings →
Design: longitudinal study Participants: 947 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Among the 393 497 All of Us participants with linked EHRs, we identified 9444 individuals (2.40%) with glaucoma diagnoses (excluding participants with diagnoses of dementia before glaucoma) and 37 776 matched controls without glaucoma. 5 key findings →
Design: cohort study Participants: 5,756 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
We found significant impacts of hypertension, diabetes and their comorbidity on cognitive impairment occurrence. 5 key findings →
Design: case-control study Participants: 40,103 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Our analysis identified risk factors that contribute to sex differences in ADEN. 4 key findings →
Design: cohort study Participants: 128,769 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
= 0.991). Optimal sleep modified both cognitive performance and dementia risk in individuals with focal epilepsy compared with stroke patients and healthy controls. 2 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Outdoor activity is linked to lower dementia risk, particularly in those living in more accessible GS. 5 key findings →
Design: longitudinal study Participants: 187,724 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Of 10 974 participants (60.0% female, mean [SD] age: 73.2 [6.8] years), 2445 developed incident all-cause dementia over 116 067 person-years of follow-up. 5 key findings →
Participants: 974 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Among 2,335 participants (mean age 52.3 ± 11.2 years; 56.6% women), CVD risk trajectories over 10 years were classified as accelerated increase (29.2%), moderate increase (30.9%), or stable (39.9%). 5 key findings →
Design: cohort study Participants: 2,335 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
In Fine-Gray models, dementia risk was higher in female than in male participants (subdistribution hazard ratio [sHR] 1·89, 95% CI 1·30-2·76) and Black than Asian participants (sHR 1·75, 1·07-2·88), lower in APOE ε2 carriers than in non-carriers (sHR 0·39, 0·17-0·88), and not significantly higher in APOE ε4 carriers than in non-carriers (sHR 1·51, 0·92-2·47). 3 key findings →
Design: cohort Participants: 805 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
55/100
Despite differences in prevalence of APOE-ε4, its association with dementia risk was similar across Chinese, Japanese, Filipino, and non-Latino White participants. 2 key findings →
Design: cohort Participants: 46,325 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
55/100
However, in this study, the additional risk of dementia conferred by being a first-degree relative, by being female, or by the probability of having an APOE epsilon4 allele appeared similar in African American and white families. 1 key finding →
Participants: 17 Evidence: low
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High HDL-C levels in elderly individuals may be associated with a decreased risk of AD. 3 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Caffeine is the most widely consumed behaviourally active substance in the western world. 4 key findings →
Design: case-control study Participants: 54 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
From across this tag
10 of the 1,131 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- The Impact of Behavioral and Psychological Symptoms of Dementia on Mental Health, Sleep Quality, and Caregiver’s Burden
- Food Insecurity, Local Food Environments, and Incident Dementia Among Older Adults
- Polygenic risk of Alzheimer disease is associated with early- and late-life processes
- Posttraumatic stress disorder and risk of dementia among US veterans
- Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study
- Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study
- Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study
- Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm
- Age at First Childbirth and Dementia Risk: A Cross‐Sectional Ecological Analysis of Female Prevalence, Sex Disparities, and Public Health Implications
- Glucagon-Like Peptide-1 Receptor Agonists and Incidence of Dementia Among Older Adults With Type 2 Diabetes: A Target Trial Emulation
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →