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Home › Research › Journals › Diabetes Care

Research published in Diabetes Care

Every study in the alzhub library that its record lists as published in Diabetes Care, summarised in plain English and scored out of 100.

These counts and lists are worked out from the library itself each time the page loads. A score rates how much weight a study can bear — its design, journal, evidence and recency — not whether its result is good news.

How the records spell this journal (2 spellings)

The 20 highest-scoring

  1. Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia Diabetes care · 2015-12-17 · · Peer-reviewed

    Pooling data from 14 studies of more than 2.3 million people, this analysis found type 2 diabetes was associated with about a 60% higher risk of dementia, and the increase was similar in women (RR 1.62) and men (RR 1.58). For vascular dementia, the link was stronger in women: women with diabetes had a 19% greater risk than men (RRR 1.19, 95% CI 1.08–1.30). The cohorts were observational, so this shows an association, not that diabetes causes dementia or that treating it would prevent dementia.

  2. Effect of Linagliptin on Cognitive Performance in Patients With Type 2 Diabetes and Cardiorenal Comorbidities: The CARMELINA Randomized Trial Diabetes care · 2019-08-09 · · Peer-reviewed
  3. Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia Diabetes Care · 2016-02-01 · · Peer-reviewed

    Type 2 diabetes was linked to about 60% higher dementia risk in both women and men, with a notably higher excess risk of vascular dementia in women. This identifies diabetes as a modifiable risk factor, but the analysis does not show that treating diabetes prevents dementia.

  4. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial Diabetes care · 2009-02-01 · · Peer-reviewed

    In people with diabetes, higher A1C levels were linked to lower scores on all four cognitive tests, suggesting worse blood sugar control goes with worse thinking. Whether lowering glucose actually improves cognitive function was not answered here and is being tested in the ongoing trial.

  5. Brain atrophy in type 2 diabetes: regional distribution and influence on cognition Diabetes care · 2013-08-12 · · Peer-reviewed

    In this cross-sectional study, type 2 diabetes was associated with more cerebral infarcts and lower total gray, white, and hippocampal volumes, with cortical atrophy resembling patterns seen in preclinical Alzheimer disease. The findings suggest neurodegeneration rather than cerebrovascular lesions may play a key role in diabetes-related cognitive impairment.

  6. Tight glycemic control and use of hypoglycemic medications in older veterans with type 2 diabetes and comorbid dementia Diabetes care · 2015-01-15 · · Peer-reviewed

    Many older veterans with diabetes and dementia had tight blood sugar control and were at high risk of hypoglycemia from intensive diabetes treatment. The authors suggest these patients may be candidates for reducing or changing diabetes medications, but the study did not test whether this affects dementia itself.

  7. Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults Diabetes care · 2012-10-15 · · Peer-reviewed

    In this longitudinal study of 372 cognitively healthy late middle-aged people, insulin resistance was examined for links to less gray matter in Alzheimer disease-sensitive brain regions and worse cognitive performance. The findings suggest insulin resistance may play a role in how Alzheimer's disease develops, but the study does not show that treating insulin resistance prevents or cures the disease.

  8. Dementia Risk in People With Type 1 Diabetes and Associated Risk Factors: A Nationwide, Register-Based Cohort Study Diabetes Care · 2025-09-19 · · Peer-reviewed

    This nationwide register-based cohort study found that people with type 1 diabetes had a higher risk of all-cause dementia, Alzheimer's disease, vascular dementia, and non-Alzheimer-nonvascular dementia compared with matched controls. Risk factors included lower education, being single, higher systolic blood pressure, higher HbA1c, history of stroke or transient ischemic attack, history of cardiovascular disease, and longer diabetes duration, but the study did not test treatments to prevent or cure dementia.

  9. Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS) Diabetes care · 2017-09-15 · · Peer-reviewed

    More-severe diabetes, defined by higher HbA1c and longer disease duration, was associated with smaller total and regional brain volumes and an increased burden of white matter hyperintensities, but prediabetes and less-severe diabetes were not. This suggests that more severe diabetes, rather than prediabetes, is linked to brain volume loss and vascular pathology.

  10. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study Diabetes care · 2011-06-16 · · Peer-reviewed
  11. The Association of Late-Life Diabetes Status and Hyperglycemia With Incident Mild Cognitive Impairment and Dementia: The ARIC Study Diabetes care · 2019-05-21 · · Peer-reviewed

    This study found that diabetes status, poor glycemic control, and longer diabetes duration were associated with worse cognitive outcomes, including incident mild cognitive impairment and dementia, over a median follow-up of 5 years. It also found that glycated albumin and fructosamine were associated with incident dementia independently of HbA1c.

  12. Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle Diabetes care · 2024-10-01 · · Peer-reviewed

    In this study of UK Biobank participants, both prediabetes and diabetes were associated with a higher brain age gap, and diabetes was further associated with an increase in brain age gap over time. Having a healthy lifestyle significantly attenuated the diabetes-brain age gap association.

  13. Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline Diabetes care · 2017-05-12 · · Peer-reviewed

    This study examined whether glucose peaks in midlife, measured by 1,5-anhydroglucitol, are associated with dementia risk and 20-year cognitive decline. It reports an association with a blood measure, so it does not show that controlling glucose peaks prevents or treats Alzheimer's disease.

  14. Contrasting Adult and Pediatric Populations in a Cohort of At-Risk Relatives in The T1D TrialNet Pathway to Prevention Study Diabetes Care · 2025-07-22 · · Peer-reviewed

    This study compares adults and children at risk of type 1 diabetes and reports differences in autoantibody patterns and progression to diabetes, with no Alzheimer's disease outcomes. It suggests that monitoring and intervention strategies for type 1 diabetes may need to differ between adults and children.

  15. Association of Type 2 Diabetes, According to the Number of Risk Factors Within Target Range, With Structural Brain Abnormalities, Cognitive Performance, and Risk of Dementia Diabetes care · 2021-09-29 · · Peer-reviewed

    In people with type 2 diabetes, this study looked at whether having more risk factors (like blood pressure, cholesterol, blood sugar) within target range was linked to better brain health and lower dementia risk. It suggests that managing these factors may help, but it does not prove that doing so prevents dementia.

  16. Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study Diabetes care · 2020-09-23 · · Peer-reviewed
  17. Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study Diabetes care · 2008-10-22 · · Peer-reviewed

    In 7,087 older French adults followed for 4 years, metabolic syndrome was linked to higher risk of vascular dementia but not Alzheimer's disease, and high triglycerides were linked to both all-cause and vascular dementia. This identifies metabolic factors associated with certain dementias but does not test a treatment or cure.

  18. Plasma Biomarkers of Brain Injury and Their Association With Brain MRI and Cognition in Type 1 Diabetes Diabetes care · 2024-09-01 · · Peer-reviewed

    Among 373 adults with type 1 diabetes, brain injury biomarkers did not show an Alzheimer's-like pattern, though higher NfL was linked to older predicted brain age and cognitive problems. The findings suggest early neurodegeneration in type 1 diabetes may involve non-amyloid mechanisms, and they do not address treating or preventing Alzheimer's disease.

  19. Insulin and cognitive function in an elderly population. The Rotterdam Study Diabetes care · 1997-05-01 · · Peer-reviewed

    This study examined the association between insulin levels after a glucose load and cognitive function in an elderly population. It is an observational study of a possible relationship and does not test any treatment, cure, or prevention.

  20. White Matter Hyperintensities Moderate the Association Between Diabetes and Non-AD Brain Atrophy Diabetes Care · 2025-10-27 · · Peer-reviewed

    Diabetes alone was not linked to brain atrophy, but diabetes and white matter hyperintensities together were linked to more atrophy, independent of Alzheimer's pathology. This suggests that diabetes-related cognitive problems may be driven mainly by cerebrovascular disease, but the study does not test any treatment.

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