- 47studies, of 27,380 in the library
- 47peer-reviewed
- 2013–2026years published
- 66median usefulness score out of 100
These counts and lists are worked out from the library itself each time the page loads. A score rates how much weight a study can bear — its design, journal, evidence and recency — not whether its result is good news.
How the records spell this journal (2 spellings)
- JAMA Internal Medicine — 8 studies
- JAMA internal medicine — 39 studies
The 20 highest-scoring
- Advance Care Planning Video Intervention Among Long-Stay Nursing Home Residents: A Pragmatic Cluster Randomized Clinical Trial
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Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial
In this randomized trial of an older population, 334 participants had follow-up cognitive tests after a median of 4.1 years. The group assigned to a Mediterranean diet plus olive oil scored better than the control-diet group on two tests (RAVLT, P = .049; Color Trail Test part 2, P = .04), with no differences on the other tests. The study measured test scores, not dementia, so it does not show that this diet prevents or treats Alzheimer's disease.
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Effect of Personalized Risk-Reduction Strategies on Cognition and Dementia Risk Profile Among Older Adults: The SMARRT Randomized Clinical Trial
In this trial of 172 older adults at elevated dementia risk, those assigned to personalized risk-reduction strategies showed larger improvements in a composite cognitive score and a better composite risk factor score after two years than the control group. This suggests multidomain risk-reduction may help cognition in people with risk factors, but it does not show that Alzheimer's disease is cured or prevented.
- An Advance Care Planning Video Decision Support Tool for Nursing Home Residents With Advanced Dementia: A Cluster Randomized Clinical Trial
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The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults
In this 12-week trial of 126 inactive older adults with cognitive complaints, global cognitive scores improved significantly over time in all groups, but there were no significant differences between the groups. This means the study did not show that combining physical and mental activity produced better cognitive results than either alone.
- Effect of the Goals of Care Intervention for Advanced Dementia: A Randomized Clinical Trial
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Effect of Collaborative Dementia Care via Telephone and Internet on Quality of Life, Caregiver Well-being, and Health Care Use: The Care Ecosystem Randomized Clinical Trial
In this randomized trial of 780 people with dementia and 780 caregivers, a telephone and internet collaborative care program improved patient quality of life, reduced emergency department visits, and decreased caregiver depression and burden compared with usual care. It improves care and well-being but does not treat, cure or prevent Alzheimer's disease itself.
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Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study
In 3,434 adults aged 65+ in Seattle followed for a mean of 7.3 years, those who had filled more anticholinergic prescriptions over the previous 10 years were more likely to develop dementia and Alzheimer's, with risk rising as cumulative dose rose. The drugs most used were tricyclic antidepressants, first-generation antihistamines and bladder antimuscarinics. This is an association, not proof the drugs cause dementia or that stopping them prevents it. The authors call for more awareness among clinicians and older adults so these drugs are used less over time.
- Evaluation of a Palliative Care Program for Nursing Homes in 7 Countries: The PACE Cluster-Randomized Clinical Trial
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Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study
This nested case-control study found that higher cumulative exposure to anticholinergic drugs was associated with increased dementia risk. It identifies a possible modifiable risk factor, but does not show that avoiding these drugs prevents Alzheimer's disease.
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Effects of the Finnish Alzheimer disease exercise trial (FINALEX): a randomized controlled trial
In a one-year randomized trial of 210 people with Alzheimer disease living at home with a spouse, everyone's daily functioning declined, but less with twice-weekly exercise: on the Functional Independence Measure scores fell 7.1 points with home exercise and 10.3 with group exercise, compared with 14.4 with usual care. The exercise groups also had significantly fewer falls, and total care costs were not higher (only the group programme's lower cost, $22,066 vs $34,121 per couple per year, was statistically significant). The trial measured physical function, not memory, and it showed slower decline, not prevention of decline.
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Association of Cardiovascular Health With Life Expectancy Free of Cardiovascular Disease, Diabetes, Cancer, and Dementia in UK Adults
This study quantified how levels of cardiovascular health relate to life expectancy free of major chronic disease, including dementia, in UK adults. It is observational, so it cannot show that improving cardiovascular health prevents dementia.
- Development and External Validation of a Mortality Prediction Model for Community-Dwelling Older Adults With Dementia
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High-Risk Medications in Persons Living With Dementia: A Randomized Clinical Trial
Mailing educational materials to patients and their prescribers did not reduce dispensing of high-risk medications such as antipsychotics, sedative-hypnotics, or strong anticholinergics. This means this type of educational mailing alone did not change prescribing for people with Alzheimer's disease or related dementias.
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A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012
This study compared dementia prevalence in the United States in 2000 and 2012 using nationally representative survey data. It examines population trends in dementia prevalence and does not test any treatment, cure, or prevention.
- Association of Clinical Outcomes With Surgical Repair of Hip Fracture vs Nonsurgical Management in Nursing Home Residents With Advanced Dementia
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Cognitive Tests to Detect Dementia: A Systematic Review and Meta-analysis
This review compared 11 cognitive screening tests across 149 studies with more than 49,000 participants for detecting dementia. It concerns diagnosis only and provides no information on treating, curing or preventing Alzheimer's disease.
- Health insurance status and the care of nursing home residents with advanced dementia
- Unrecognized Cardiovascular Emergencies Among Medicare Patients
- Comparison of Particulate Air Pollution From Different Emission Sources and Incident Dementia in the US
See all 47 studies, with filters →
Newest additions
- Benefits and Harms of Dementia Screening for Family Members of Older Adults: A Randomized Clinical Trial
- Patient and Caregiver Outcomes of Health System, Community-Based, and Usual Dementia Care
- Continued Use of Cholinesterase Inhibitors and Memantine in Hospice
- Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias
- Dementia Prevention and Treatment: A Narrative Review
- Care Ecosystem Collaborative Model and Health Care Costs in Medicare Beneficiaries With Dementia: A Secondary Analysis of a Randomized Clinical Trial
- Six-Year Cognitive Trajectory in Older Adults Following Major Surgery and Delirium
- Low-Value Care at the Actionable Level of Individual Health Systems
- The Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer Disease and Other Dementias (TRAIN-AD): A Cluster Randomized Clinical Trial
- Financial Presentation of Alzheimer Disease and Related Dementias
From across this list
3 of the 46 studies in this list, picked by a fixed rule (a hash of each study's address), not by score or date. The same 3 appear here every time.
By review status
- Peer-reviewed — 47