- 34studies, of 27,380 in the library
- 34peer-reviewed
- 2013–2026years published
- 64median usefulness score out of 100
These counts and lists are worked out from the library itself each time the page loads. A score rates how much weight a study can bear — its design, journal, evidence and recency — not whether its result is good news.
How the records spell this journal (2 spellings)
- JAMA Psychiatry — 9 studies
- JAMA psychiatry — 25 studies
The 20 highest-scoring
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Association of the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet With the Risk of Dementia
This analysis of three cohort studies plus a meta-analysis found that higher MIND diet scores were linked to lower dementia risk. Because it is observational, it shows an association and cannot prove that the diet prevents dementia.
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Effectiveness and Safety of Dementia Care Management in Primary Care: A Randomized Clinical Trial
This randomized clinical trial found that dementia care management significantly decreased behavioral and psychological symptoms of dementia. It suggests that collaborative care provided by trained nurses can improve relevant patient outcomes.
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Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis
Pooling 57 studies of 20,892 people with mild cognitive impairment, this review estimated that about 1 in 3 (32%) have depression. The figure was 25% in community samples and 40% in clinic samples, and estimates varied widely between studies. It measures how common depression is, not what causes it, and it does not test any treatment, cure or prevention for Alzheimer's disease.
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Effect of a Lay Counselor Intervention on Prevention of Major Depression in Older Adults Living in Low- and Middle-Income Countries: A Randomized Clinical Trial
This randomized trial enrolled 181 older adults in low- and middle-income countries to test a lay counselor intervention for prevention of major depression. It addresses depression prevention, not the treatment, cure, or prevention of Alzheimer's disease.
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Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm
In 90,786 veterans aged 65 or older with dementia, this study set out to measure how much a new prescription for an antipsychotic changes the absolute risk of death over 180 days. For haloperidol, death risk was 3.8 percentage points higher than in matched people not taking the drug (95% CI 1.0–6.6), and the authors conclude the absolute effect of antipsychotics "may be higher than previously reported and increases with dose." This is an observational association, not proof of cause, and it is a reason to discuss risks and alternatives with the prescriber, not to stop a medication without advice.
- Association of Lithium in Drinking Water With the Incidence of Dementia
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Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study
Depressive symptoms in midlife, even when chronic or recurring, did not significantly increase dementia risk, while symptoms closer to diagnosis did. This suggests depression may be an early sign of dementia rather than a cause that could be treated to prevent it.
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Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies
In 987 brain donors (average age at death 90) from three population-based cohorts, people who had ever had delirium already scored 2.8 MMSE points lower six years before death, and delirium occurring alongside dementia-type brain changes was linked to faster decline than either one alone would predict. The authors conclude delirium appears to act "independently and multiplicatively" with classic dementia pathology, possibly through brain processes they did not measure. It is an observational study: it shows an association and does not test whether preventing or treating delirium changes the course of dementia.
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Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial
This large randomized trial found no significant differences in the proportions of older adults with elevated depression scores between those taking low-dose aspirin and those taking placebo. It tested aspirin for prevention of depression, not for treating, curing, or preventing Alzheimer's disease.
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Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia
In 2488 older adults, a high and increasing trajectory of depressive symptoms was associated with increased risk of dementia, while a moderate and increasing trajectory was not. This is an observational link between symptom patterns and dementia risk, not evidence that treating depression prevents dementia.
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Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment
This cohort study assessed whether specific features of subjective cognitive decline predict future mild cognitive impairment, Alzheimer's disease, and all-cause dementia. It is about identifying risk, not about treating, curing, or preventing the disease.
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Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment: A Randomized Clinical Trial
In this trial of 375 older adults, cognitive remediation and transcranial direct current stimulation slowed cognitive decline in some participants, particularly those with remitted major depressive disorder. The effect on delaying progression from normal cognition to mild cognitive impairment or from mild cognitive impairment to dementia was weak and not significant.
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Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study
Depressive symptoms closer to a dementia diagnosis were linked to higher dementia risk, while symptoms up to 28 years earlier were not, and symptoms began diverging about 11 years before diagnosis. The authors conclude this pattern suggests late-life depression is more likely an early warning sign of brewing dementia than a cause of it.
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Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression
This study examined heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression. It is about late-life depression and does not test any treatment, cure, or prevention for Alzheimer's disease.
- Neuropsychiatric Ramifications of Severe COVID-19 and Other Severe Acute Respiratory Infections
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Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study
In people without symptoms who had abnormal amyloid levels, those with more anxiety symptoms declined faster in memory and thinking than those with less anxiety. Since anxiety can be treated, this finding may help identify and manage people at higher risk, though it does not show that treating anxiety prevents Alzheimer's disease.
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Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia
This cohort study found that older adults with recent diagnoses of mild cognitive impairment or dementia were at increased risk of attempting suicide. It identifies a risk needing supportive services and does not test any treatment, cure or prevention for Alzheimer's disease.
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Neurofilament Light Chain and Differentiation of Behavioral Variant Frontotemporal Dementia From Psychiatric Disorders
This systematic review found that levels of neurofilament light chain in CSF and blood were higher in patients with behavioral variant frontotemporal dementia than in patients with psychiatric disorders. It suggests NfL may help supplement clinical diagnostic evaluations in telling these conditions apart, but it is about diagnosis, not treating, curing or preventing Alzheimer's disease.
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Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia
This cross-sectional study examined whether amyloid-beta aggregation is associated with cognitive functioning in 2908 people with normal cognition and 4133 with mild cognitive impairment. It describes an association only and does not test any treatment, so it cannot show how to treat, cure, or prevent Alzheimer's disease.
- Medial temporal lobe structures and hippocampal subfields in psychotic disorders: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study
See all 34 studies, with filters →
Newest additions
- The 25-Year Evolution of Lithium as a Disease-Modifying Agent in Dementia: A Narrative Review
- Dementia in Severe Schizophrenia
- Alzheimer Disease–Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment
- Sweetened Beverages and Incident All-Cause Dementia Among Older Adults
- Genetic Analysis of Retinal Cell Types in Neuropsychiatric Disorders
- Psychosis in Alzheimer Disease and Elevations in Disease-Relevant Biomarkers
- Social Vulnerability and Prevalence and Treatment for Mental Health and Substance Use Disorders
- Longitudinal Associations of Mental Disorders With Dementia: 30-Year Analysis of 1.7 Million New Zealand Citizens
- Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults
- Prediction of Individual Response to Electroconvulsive Therapy via Machine Learning on Structural Magnetic Resonance Imaging Data
By review status
- Peer-reviewed — 34