Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Growing evidence highlights sex-related differences in the pathogenesis of Alzheimer's disease (AD).
Why it matters
In a mouse model of Alzheimer's-like pathology before symptoms appeared, male and female mice showed opposite changes in hippocampal neuronal activity, and males had more microglia and plaque coverage. These early animal findings point to sex differences in the disease process but do not yet indicate a treatment.
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Both LBDs and SPs exhibit distinct visual aberrations, ranging from minor metamorphopsias to complex hallucinations.
Why it matters
This narrative review compares visual hallucinations in serotonergic psychedelics and Lewy body diseases and suggests they may share neural mechanisms, including serotonin receptor involvement. It proposes future research directions but reports no treatment, cure or prevention tested in patients.
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Traumatic brain injury (TBI) has been linked to the development of neurodegenerative diseases, particularly Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE).
Why it matters
This review examines the possible relationship between traumatic brain injury and cerebral amyloid angiopathy, noting that diagnosing CAA after head trauma is difficult because symptoms and pathologies overlap. It raises questions for future research rather than reporting any treatment, cure or prevention.
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40/100
Repulsive guidance molecule-a (RGMa) has emerged as a significant therapeutic target in a variety of neurological disorders, including neurodegenerative diseases and acute conditions.
Why it matters
This review reports that in preclinical studies, blocking RGMa with agents like elezanumab improved neuronal survival and recovery, but these findings are not yet confirmed in people. The authors state that further clinical trials are needed to validate the safety and efficacy of RGMa-targeted therapies.
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Chronic cerebral hypoperfusion can lead to neuronal necrosis, trigger inflammatory responses, promote white matter damage, and ultimately result in cognitive impairment.
Why it matters
This review describes how chronic cerebral hypoperfusion activates microglia, which can damage the blood-brain barrier and myelin sheath and contribute to vascular dementia. It discusses potential therapeutic implications of targeting microglia, but does not report a tested treatment.
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Small extracellular vesicles (sEVs), including exosomes as a subtype, with a diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting a diverse array of bioactive molecules, including proteins, nucleic acids, and lipids, thereby facilitating intercellular communication and modulating cellular functions.
Why it matters
This review discusses the role of small extracellular vesicles in vascular dementia pathogenesis and their potential as therapeutic approaches, noting that current treatment emphasizes symptom management with no specific pharmacological cure. It offers novel insights for future research but no confirmed therapy.
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246 older adults (mean age = 58.84 ± 7.00 years; 38.21 % males) were included in our data analysis.
Why it matters
In 246 older adults, lower retinal arteriole and venule density was linked to higher small vessel disease burden in the brain. This suggests eye imaging might reflect brain vessel changes, but it is an association study and does not show any effect on treating or preventing dementia.
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40/100
High Resolution Image Download MS PowerPoint Slide The aggregation of α-synuclein is crucial to the development of Lewy body diseases, including Parkinson’s disease and dementia with Lewy bodies.
Why it matters
This laboratory study used Raman spectroscopy and machine learning to track how purified alpha-synuclein protein clumps together over seven days, a process relevant to Lewy body diseases such as dementia with Lewy bodies. It is early, in-vitro work and does not test any treatment, prevention or cure in people.
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BackgroundSleep disturbances often precede motor symptoms in neurodegenerative diseases like Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Why it matters
In a mouse model of synucleinopathy, sleep architecture changes and brain wave shifts occurred early, along with signs of brain inflammation, before REM sleep deficits appeared. These early sleep and inflammation changes may help understand how sleep problems develop in diseases like Parkinson's and dementia with Lewy bodies, but this is animal research.
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40/100
Dementia affects over 55 million people globally, with early cognitive decline, such as Mild Cognitive Impairment (MCI), often preceding neurodegenerative diseases.
Why it matters
This preliminary study of nine participants with mild to moderate dementia found high engagement, increased autonomy and focus, and positive emotional responses during four weeks of training with the social robot Pepper. It did not measure whether this training improves or prevents Alzheimer's disease, so any cognitive or emotional benefit remains unproven.
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Patients with hearing impairment presented slightly altered results on cognitive tests, typical of a mild cognitive impairment.
Why it matters
This study found that patients with hearing impairment and mild cognitive impairment had increased serum levels of neurofilament light chain and phospho-tau 181, and these values improved after hearing aid fitting. These biomarkers may be useful for monitoring, but no treatment or cure for Alzheimer's disease is tested.
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Gastric cancer, a prevalent malignant tumor worldwide, poses a significant challenge to global health.
Why it matters
This review is about gastric cancer and contains no information on Alzheimer's disease treatment, cure, or prevention. It summarizes environmental, dietary, lifestyle, and infectious risk factors for gastric cancer.
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A network neuroscience perspective can significantly advance the understanding of neurodegenerative disorders, particularly frontotemporal dementia (FTD).
Why it matters
Using combined cortical thickness and FDG-PET network analysis across two sites, this study found increased global multiplex participation coefficient in primary progressive aphasia and nodal changes in frontal and temporal regions. These are imaging findings about disease patterns and do not test any treatment, cure or prevention.
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Disease-specific oligomers Tau assay system is anticipated in Alzheimer disease (AD) to elucidate their etiological roles.
Why it matters
Researchers developed a new lab test that detects large clumps of tau protein in brain tissue and found these clumps increase with disease stage. This is laboratory work only and does not yet provide a treatment or cure.
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Protein folding is a critical process that determines the functional state of proteins.
Why it matters
This study introduces a method for classifying protein folding states, which the authors say could help understand disease mechanisms and develop therapeutic strategies. It is a computational method tested on two proteins and reports no findings about treating or preventing Alzheimer's disease.
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Our data provide an atlas of immunological alterations that can lead to improved diagnostic and therapeutic strategies for HFpEF.
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This study did not demonstrate evidence of a significant change in the MFV in the middle cerebral arteries or evidence of a significant change in the PI between UPA and EPA groups.
Why it matters
In this small pilot trial of 23 participants, 26 weeks of aerobic exercise training did not significantly change blood flow velocity or pulsatility in the middle cerebral arteries. Although fitness improved in the exercise group, this study found no evidence that exercise training changed these measures of cerebral blood flow.
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40/100
Adult brain activities are generally believed to be dominated by chemical and electrical transduction mechanisms.
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Microglia-mediated synaptic loss contributes to the development of cognitive impairments in Alzheimer's disease (AD).
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Next, we review human PET imaging results in multiple neurodegenerative disorders.
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Salvia species have a longstanding traditional culinary use, mostly being consumed in the Mediterranean diet as a common herb added to food.
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Alzheimer's disease (AD) is the most dominant form of dementia characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tau tangles (NFTs).
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Recent advances have revealed common pathological changes in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis with related frontotemporal dementia (ALS/FTD).
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Materials and methods Differentially expressed proteins (DEPs) in patients after cerebral ischemic stroke were revealed by a RayBio protein array.
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Activation of glial cells and neuroinflammation play an important role in the onset and development of Alzheimer's disease (AD).
Why it matters
In a mouse model, lowering TREM2 worsened neuroinflammatory responses through a TLR4-mediated pathway. This is animal research and does not yet show a treatment for people.
From across this topic
10 of the 4,748 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
- Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila
- Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum
- Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis
- α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
- Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer's Disease and Systemic Inflammation
- Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline
- Sex-aware Cross-tissue Regulatory Transformer Identified Sexually Dimorphic Alzheimer's Disease Risk Loci and Causal Cellular Circuit
- Absorption and Co-expression Modules Show Where Polygenic and Proteomic Risk Scores Diverge in Neurodegenerative Diseases
- Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807