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Home › Research › Topic

Brain proteins, microglia and lab models

4,766 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Gating of fear in prelimbic cortex by hippocampal and amygdala inputs

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2012-11-01 Hippocampus size on brain scans

    The prefrontal cortex (PFC) regulates emotional responses, but it is unclear how PFC integrates diverse inputs to select the appropriate response.

  2. Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Autophagy 2012-08-09 Disease mechanisms

    The most common neurodegenerative diseases are characterized by the accumulation of misfolded proteins.

  3. Cognitive enhancement by pharmacological and behavioral interventions: the murine Down syndrome model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemical pharmacology 2012-08-08 Down syndrome and Alzheimer's

    The cognitive deficits in Down syndrome (DS) are attributed to an excessive hippocampal inhibition, which obstructs neuronal plasticity and normal learning and memory, a view which is largely based on studies of Ts65Dn mice, the best characterized mouse model of DS.

    Why it matters

    In the Ts65Dn mouse model of Down syndrome, reducing GABAergic inhibition improved cognitive performance, and the Alzheimer drugs memantine and donepezil largely failed to show any benefit. These are mouse findings, though one compound acting on α5 GABA-A receptors has entered clinical trials in Down syndrome.

  4. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology 2012-08-04 Disease mechanisms

    In Alzheimer disease (AD), deposition of neurofibrillary tangles and loss of synapses in the neocortex and limbic system each correlate strongly with cognitive impairment.

  5. Tau alternative splicing in familial and sporadic tauopathies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemical Society transactions 2012-08-01 Disease mechanisms

    Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain.

  6. Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2012-05-18 Disease mechanisms

    Increased Tau protein amyloidogenicity has been causatively implicated in several neurodegenerative diseases, collectively called tauopathies.

  7. Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012-05-01 Clinical safety

    Delirium is a profound, acute confusional state that leads to long-term cognitive decline.

  8. Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2012-04-12 Disease mechanisms

    Insulin-like growth factor (IGF)-1 is an important neurotrophic hormone.

  9. Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 2012-04-10 Disease mechanisms

    Disruption of intracellular calcium homeostasis via abnormal and excessive activation of ryanodine receptors plays an important role in the neuropathology of Alzheimer's disease.

  10. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Autophagy 2012-04-01 Disease mechanisms

    More than 30 neurodegenerative diseases including Alzheimer disease (AD), frontotemporal lobe dementia (FTD), and some forms of Parkinson disease (PD) are characterized by the accumulation of an aggregated form of the microtubule-binding protein tau in neurites and as intracellular lesions called neurofibrillary tangles.

  11. Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012-04-01 Clinical safety

    Hypertension, a powerful risk factor for stroke and dementia, has damaging effects on the brain and its vessels.

  12. Abnormalities in hippocampal functioning with persistent pain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012-04-01 Hippocampus size on brain scans

    Chronic pain patients exhibit increased anxiety, depression, and deficits in learning and memory.

  13. Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2012-03-05 Disease mechanisms

    Cerebral deposition of amyloid β protein (Aβ) is an invariant feature of Alzheimer disease (AD), and epidemiological evidence suggests that moderate consumption of foods enriched with phenolic compounds reduce the incidence of AD.

  14. Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 2012-02-01 Disease mechanisms

    Traumatic brain injury (TBI) is a major environmental risk factor for subsequent development of Alzheimer disease (AD).

  15. Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurochemistry international 2012-01-27 Clinical safety

    TDP-43 proteinopathies are characterized by loss of nuclear TDP-43 and accumulation of the protein in the cytosol as ubiquitinated protein aggregates.

  16. A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2011-12-08 Disease mechanisms

    Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia in the elderly.

  17. CSF biomarkers in different phenotypes of Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neural transmission (Vienna, Austria : 1996) 2011-11-08 Tau biomarkers

    CSF biomarker studies were performed in 6 patients each with tremor-dominant (TD) and non-tremor-dominant (NT) Parkinson disease (PD) patients, 27 Alzheimer disease (AD) and 17 age-matched controls.

    Why it matters

    In a small group of patients, this study found that total tau levels and the ratio of tau to amyloid-42 in spinal fluid were higher in people with non-tremor-dominant Parkinson's disease and Alzheimer's disease than in those with tremor-dominant Parkinson's disease or controls. The authors suggest these markers may reflect the severity of nerve cell loss, but the study is small and does not test a treatment.

  18. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2011-11-04 Disease mechanisms

    Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be modulated by disease-associated tau modifications suggest that secretion may be an important element in tau-induced neurodegeneration.

  19. c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2011-10-27 Disease mechanisms

    Alzheimer disease (AD) is characterized by cognitive impairment that starts with memory loss to end in dementia.

  20. Synaptic dysfunction in progranulin-deficient mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2011-10-25 Disease mechanisms

    Progranulin haploinsufficiency is a common cause of familial frontotemporal dementia (FTD), but the role of progranulin in the brain is poorly understood.

  21. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2011-10-25 Disease mechanisms

    Tauopathies, characterized by neurofibrillary tangles (NFTs) of phosphorylated tau proteins, are a group of neurodegenerative diseases, including frontotemporal dementia and both sporadic and familial Alzheimer's disease.

  22. Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research bulletin 2011-10-21 Hippocampus size on brain scans

    Reduction of cerebral blood flow is an important risk factor for dementia states and other brain dysfunctions.

  23. NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2011-09-30 Disease mechanisms

    Tauopathies, including Alzheimer's disease, are a group of neurodegenerative diseases characterized by abnormal tau hyperphosphorylation that leads to formation of neurofibrillary tangles.

  24. Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2011-09-28 Disease mechanisms

    Alzheimer's disease (AD) is a progressive, neurodegenerative disorder and the most prevalent senile dementia.

  25. The interplay of cholinergic function, attention, and falls in Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Movement disorders : official journal of the Movement Disorder Society 2011-09-06 Clinical safety

    Dopamine loss in the substantia nigra causes several of the motor signs seen in Parkinson's disease, but there is now increasing evidence highlighting the importance of cholinergic loss in the pathophysiology of nonmotor symptoms.

From across this topic

10 of the 4,748 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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