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Home › Research › Topics › syndrome

syndrome

534 studies tagged syndrome, dated 1975-09-01 to 2026-10-30. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Differential endothelial cell remodeling in Down syndrome and APP duplication drives distinct blood brain barrier dysfunction 2026-10-30
  2. Memory and Plasma pTau217 Refine Prognosis in Down Syndrome 2026-10-02
  3. Tau extent is associated with lower cognition in Down syndrome-related Alzheimer's disease 2026-10-01

Studies

534 studies carry this tag.

Date range

1975 to 2026

Top journals

  • Proceedings of the National Academy of Sciences of the United States of America 21
  • Alzheimer s & Dementia 20
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 15
  • Neurology 14
  • Neuroscience letters 14

239 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Thyroid stimulating hormone-receptor overexpression in brain of patients with Down syndrome and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Life sciences 1999-01-01 Down syndrome and Alzheimer's

    Thyroid hormone abnormalities are strongly associated with Down Syndrome (DS) with elevated thyroid stimulating hormone (TSH) levels as the most consistent finding.

  2. Biomarkers of oxidative stress are significantly elevated in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Free radical biology & medicine 1998-12-01 Down syndrome and Alzheimer's

    There is convincing epidemiological and in vitro evidence of chronic oxidative stress in individuals with Down syndrome (DS).

  3. Long-term basal forebrain cholinergic-rich grafts derived from trisomy 16 mice do not develop beta-amyloid pathology and neurodegeneration but demonstrate neuroinflammatory responses

    ✓ Peer-reviewed alzhub usefulness score 29 out of 100. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998-11-01 Down syndrome and Alzheimer's

    Patients with Down syndrome (human trisomy 21) develop neuropathological and cholinergic functional defects characteristic of Alzheimer's disease, which has been attributed to the location of the Alzheimer beta-amyloid precursor protein on chromosome 21.

  4. Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuropathology and experimental neurology 1998-11-01 Down syndrome and Alzheimer's

    To gain insights into the different forms of modified amyloid beta peptides (A beta) in the Alzheimer disease (AD) and Down syndrome (DS) brain, we used two-site ELISAs with antibodies specific for isomerized (i.e. A beta with L-isoaspartate at positions 1 and 7) and pyroglutamate-modified (i.e. A beta beginning with pyroglutamate at position 3) forms of A beta to quantitate the levels of these different A beta peptides in formic acid extracts of AD and DS frontal cortex.

  5. Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L)

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 1998-09-01 Down syndrome and Alzheimer's

    The presenilin-1 (PS1) gene mutation (Pro117Leu), recently identified in a Polish family is characterized by the earliest reported onset (from 24-31 years) of Alzheimer disease (AD) and a very short duration of disease (4-6 years).

  6. Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuroscience letters 1998-09-01 Hippocampus size on brain scans

    Ts65Dn mouse displays a partial triplication of chromosome 16 and is adopted as a model for Down syndrome (DS).

  7. Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurobiology of aging 1998-09-01 Risk genes beyond APOE

    Chronic overexpression of the neurite growth-promoting factor S100beta has been implicated in the pathogenesis of neuritic plaques in Alzheimer's disease.

  8. Effect of long term bed rest in men on enzymatic antioxidative defence and lipid peroxidation in erythrocytes

    ✓ Peer-reviewed alzhub usefulness score 29 out of 100. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 1998-07-01 Down syndrome and Alzheimer's

    However, bed rest results in many alterations which are disadavantageous.

  9. Apolipoprotein E epsilon 4 alleles and meiotic origin of non-disjunction in Down syndrome children and in their corresponding fathers and mothers

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Neuroscience letters 1998-05-01 Down syndrome and Alzheimer's

    An increased risk of Alzheimer disease (AD) has been reported in young mothers of Down syndrome (DS) probands.

  10. Glucose, memory, and aging

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The American journal of clinical nutrition 1998-04-01 Down syndrome and Alzheimer's

    Circulating glucose concentrations regulate many brain functions, including learning and memory.

  11. Molecular mapping of Alzheimer-type dementia in Down's syndrome

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Annals of neurology 1998-03-01 Risk genes beyond APOE

    Previous research has hypothesized an association between Alzheimer's disease and the amyloid precursor protein (APP) gene found on chromosome 21.

  12. The value of the Rivermead Behavioural Memory Test (Children's Version) in an epidemiological study of older adults with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The British journal of clinical psychology 1998-02-01 Down syndrome and Alzheimer's

    The Rivermead Behavioural Memory Test for Children (RBMT-C) was used to assess a population-based sample of 74 people with Down syndrome (DS) aged 30 years and over (range 30-65 years) living in the Cambridge health district.

  13. Tubulin immunopositive structures resembling intracellular neurofibrillary tangles

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Neurobiology of aging 1998-01-01 Down syndrome and Alzheimer's

    Tau protein promotes microtubule assembly.

  14. Cerebral cortical astroglia from the trisomy 16 mouse, a model for down syndrome, produce neuronal cholinergic deficits in cell culture

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1997-11-01 Down syndrome and Alzheimer's

    Trisomy 21 (Down syndrome) is associated with a high incidence of Alzheimer disease and with deficits in cholinergic function in humans.

  15. Evidence against increased oxidative DNA-damage in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuroscience letters 1997-10-01 Down syndrome and Alzheimer's

    In Down syndrome (DS), oxidative DNA-damage may play a role in the pathogenesis of characteristic mental retardation and precocious dementia of Alzheimer type.

  16. [The apolipoprotein E genotype and Down's syndrome]

    ✓ Peer-reviewed alzhub usefulness score 27 out of 100. Revista clinica espanola 1997-10-01 Down syndrome and Alzheimer's

    Some individuals with Down syndrome develop an Alzheimer-type dementia in the third and fourth decades of life.

  17. Developmental immunohistochemistry of growth inhibitory factor in normal brains and brains of patients with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Pediatric neurology 1997-09-01 Down syndrome and Alzheimer's

    Growth inhibitory factor, a new metallothioneinlike protein, was investigated at postmortem examination in the brains of 18 patients with Down syndrome ranging in age from 18 weeks gestation to 50 years of age and in 20 age-matched normal controls by developmental immunohistochemistry.

  18. Alzheimer-like visual deficits in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer disease and associated disorders 1997-06-01 Down syndrome and Alzheimer's

    Patients with Alzheimer disease (AD) show visual impairments in color discrimination (blue hues), stereoacuity, and contrast sensitivity.

  19. Allelic variability in D21S11, but not in APP or APOE, is associated with cognitive decline in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuroreport 1997-05-01 Down syndrome and Alzheimer's

    Genetic variation in the APOE gene and variation in chromosome 21 genotypes, including the APP locus, may influence age-associated cognitive decline in adults with Down syndrome.

  20. Immunoreactivity of presenilin-1 in human, rat and mouse brain

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Brain research 1997-05-01 Down syndrome and Alzheimer's

    Monoclonal antibodies (mAbs) D3G6 and C8A5, specific for amino acid residues 160-168 of S182 protein, immunolabeled neurons, ependymal and choroid plexus cells, and myocytes in brain sections from normal subjects and people with Alzheimer disease or Down syndrome and in rats and mice.

  21. Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 31 out of 100. Current opinion in neurology 1997-04-01 Down syndrome and Alzheimer's

    Down syndrome, trisomy of chromosome 21, is well investigated because it is a genetic disease with characteristic mental retardation and precocious dementia of Alzheimer type.

  22. Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuroscience letters 1997-02-01 Down syndrome and Alzheimer's

    In order to study whether Alzheimer-like neuropathological changes involve the central histaminergic system we measured the concentration of histamine, its precursor histidine as well as the activity of histidine decarboxylase (HDC) and histamine-N-methyl-transferase (HMT) in frontal cortex of aging Down syndrome (DS) patients, Alzheimer patients and control individuals.

  23. Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Molecular and chemical neuropathology 1997-01-01 Down syndrome and Alzheimer's

    Neuritic pathology is a major neuroanatomical correlate of dementia in Alzheimer disease (AD).

  24. Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. American journal of medical genetics 1997-01-01 Down syndrome and Alzheimer's

    During a study of the familial aggregation of Down syndrome (DS) and Alzheimer disease (AD), we observed an increase in mosaicism for disomy 21 in older individuals with DS.

  25. Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. American journal of mental retardation : AJMR 1997-01-01 Down syndrome and Alzheimer's

    Institutionalized patients with Down syndrome (n = 307) were monitored for 5 to 10 years prospectively to determine prevalence of Alzheimer-type dementia.

  26. The role of magnetic resonance imaging in the diagnosis of Alzheimer disease in adults with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Archives of neurology 1996-12-01 Down syndrome and Alzheimer's

    Magnetic resonance imaging is potentially a valuable tool in the diagnosis of Alzheimer disease in adults with Down syndrome, particularly in individuals for whom standard intellectual assessments are not possible.

  27. Abnormal pattern of platelet APP isoforms in Alzheimer disease and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Archives of neurology 1996-11-01 Down syndrome and Alzheimer's

    A consistent alteration in platelet APP isoforms has been found in Alzheimer disease and Down syndrome.

  28. Brain cognition and metabolism in Down syndrome adults in association with development of dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuroreport 1996-11-01 Down syndrome and Alzheimer's

    To identify changes in brain functions associated with the development of dementia, brain metabolism and cognition were assessed repeatedly in 12 adults with Down syndrome (DS) using positron emission tomography and neuropsychological tests.

  29. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1996-11-01 Down syndrome and Alzheimer's

    To study the pathogenesis of central nervous system abnormalities in Down syndrome (DS), we have analyzed a new genetic model of DS, the partial trisomy 16 (Ts65Dn) mouse.

  30. Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Acta neuropathologica 1996-09-01 Down syndrome and Alzheimer's

    A 53-year-old Japanese woman with a point mutation in mitochondrial DNA (tRNALeu(UUR), nt3243) consistent with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) and Alzheimer-type brain pathology is reported.

  31. Decreased cyclin dependent kinase in brain of patients with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Neuroscience letters 1996-09-01 Down syndrome and Alzheimer's

    In order to study whether phosphokinases might be involved in the neuropathology of Down Syndrome (DS) and Alzheimer disease (AD), cyclin dependent kinase (CDK) activity and protein, phosphokinase C (PKC) and phosphokinase A (PKA) activities have been determined in frontal lobes of DS, AD and control brains.

  32. Huntington's disease and eyeblink classical conditioning: normal learning but abnormal timing

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Journal of the International Neuropsychological Society : JINS 1996-07-01 Down syndrome and Alzheimer's

    On the basis of what is known about the neural circuitry essential or normally involved in eyeblink classical conditioning (EBCC), the pattern of neurodegeneration in Huntington's disease (HD) would not appear to interfere with this type of learning.

  33. Dementia and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 29 out of 100. The Journal of family practice 1996-06-01 Down syndrome and Alzheimer's

    Through deinstitutionalization, more adults with mental retardation are living in the community under the care of family physicians.

  34. Differential susceptibility to neurofibrillary pathology among patients with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Dementia (Basel, Switzerland) 1996-05-01 Down syndrome and Alzheimer's

    Individual differences in the development of neurofibrillary changes were examined in eight cortical regions in the brains of 43 subjects with Down syndrome (DS; age range, 15-69 years) using sections stained with monoclonal antibodies (mAb) tau-1 and 3-39.

  35. Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1996-05-01 Down syndrome and Alzheimer's

    The neurodegeneration and amyloid deposition of sporadic Alzheimer disease (AD) also occur in familial AD and in all trisomy-21 Down syndrome (DS) patients, suggesting a common pathogenetic mechanism.

  36. Cognition-related EEG abnormalities in nondemented Down syndrome subjects

    ✓ Peer-reviewed alzhub usefulness score 29 out of 100. Dementia (Basel, Switzerland) 1996-03-01 Down syndrome and Alzheimer's

    Down syndrome (DS) subjects develop Alzheimer disease (AD) histopathology before they develop dementia.

  37. Polyamines in frontal cortex of patients with Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Neuroscience letters 1996-03-01 Down syndrome and Alzheimer's

    Polyamines may play an important role in brain development, mature brain function and also in neurodegenerative conditions.

  38. Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurobiology of Disease 1996-02-01 Down syndrome and Alzheimer's

    Patients with trisomy 21 [Down syndrome (DS)] progressively develop amyloid beta-protein (A beta) deposits and then other features of Alzheimer's disease (AD), apparently due to increased gene dosage and thus expression of the beta-amyloid precursor protein.

  39. Down syndrome with partial duplication and del (21) syndrome: study protocol and call for collaboration. Study I: Clinical assessment

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Clinical genetics 1996-01-01 Down syndrome and Alzheimer's

    We report on the clinical and cytogenetic assessment of five cases of Down syndrome phenotype with either a partial duplication of chromosome 21 or a normal karyotype, and we quote a case of del (21q) syndrome.

  40. Endogenous opioids in frontal cortex of patients with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Neuroscience letters 1996-01-01 Down syndrome and Alzheimer's

    The main purpose of this study was to investigate differences regarding endogenous opioids in post-mortem frontal cortex of adult patients with Down syndrome (DS), patients with Alzheimer disease (AD) and neurologically healthy persons, respectively, using specific radioimmunoassays.

  41. Prevalence of dementia in adults with and without Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. American journal of mental retardation : AJMR 1996-01-01 Down syndrome and Alzheimer's

    Declines in adaptive behavior were examined in a study of dementia in adults with Down syndrome and other forms of mental retardation.

  42. [Parapsychotic disorders in mentally handicapped (particularly in Down's syndrome)]

    ✓ Peer-reviewed alzhub usefulness score 27 out of 100. Annales medico-psychologiques 1995-12-01 Down syndrome and Alzheimer's

    Para psychotic troubles in Mentally Handicapped Persons (particularly in Down syndrome)-Clinical examples of M.H.P. which had no trouble until their 25-40 (years) except their intellectual defect and then, slide in psychiatric or para psychiatric behaviour.

  43. Excessive glutamine sensitivity in Alzheimer's disease and Down syndrome lymphocytes

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Journal of the neurological sciences 1995-11-01 Down syndrome and Alzheimer's

    In addition to clinical and neuropathological similarities between Alzheimer's disease and Down syndrome there are genetic and biochemical data which suggest common disease mechanism.

  44. A mouse model for Down syndrome exhibits learning and behaviour deficits

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature genetics 1995-10-01 Down syndrome and Alzheimer's

    Trisomy 21 or Down syndrome (DS) is the most frequent genetic cause of mental retardation, affecting one in 800 live born human beings.

  45. Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-10-01 Down syndrome and Alzheimer's

    The survival of cultured mouse hippocampal neurons was found to be greatly enhanced by micromolar concentrations of the excitatory neurotransmitter glutamate.

  46. Role of increased cerebral myo-inositol in the dementia of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Magnetic resonance in medicine 1995-06-01 Down syndrome and Alzheimer's

    The purpose of this study was to determine cerebral myo-inositol (mI) in adults with Down syndrome (DS), and to trace the chronobiology of DS to Alzheimer disease (AD).

  47. Detection of Alzheimer disease in individuals with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. American journal of mental retardation : AJMR 1995-05-01 Down syndrome and Alzheimer's

    A comprehensive baseline of emotional functioning was established for adults with Down syndrome.

  48. Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-04-01 Genetics

    The discovery that the epsilon 4 allele of the apolipoprotein E (apoE) gene is a putative risk factor for Alzheimer disease (AD) in the general population has highlighted the role of genetic influences in this extremely common and disabling illness.

  49. [Alzheimer-type dementia and Down syndrome]

    ✓ Peer-reviewed alzhub usefulness score 26 out of 100. Ugeskrift for laeger 1995-02-01 Down syndrome and Alzheimer's

    Dementia is seen earlier and more often in patients with Down syndrome (DS) than in the general population.

  50. Assessment of cognitive decline associated with aging: a comparison of individuals with Down syndrome and other etiologies

    ✓ Peer-reviewed alzhub usefulness score 32 out of 100. Research in developmental disabilities 1995-01-01 Down syndrome and Alzheimer's

    Cognitive processes and their decline with aging were studied in individuals with Down Syndrome (DS) and individuals of comparable mental handicap without Down Syndrome (NonDS).

From across this tag

10 of the 527 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts