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small
904 studies tagged small, dated 1975-09-01 to 2026-09-14. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease 2026-09-14
- Cerebral Small Vessel Disease and Risk of Cardiovascular Events and All-Cause Mortality: The Framingham Heart Study 2026-09-07
- Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study 2026-09-01
Studies
904 studies carry this tag.
Date range
1975 to 2026
Top journals
- Neurology 93
- Stroke 61
- Alzheimer s & Dementia 31
- Brain : a journal of neurology 20
- Annals of neurology 19
342 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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These results suggest that mechanisms leading to atherosclerosis might also lead to an increased number of perivascular spaces.
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Over the past decade, public awareness of the long-term pathological consequences of traumatic brain injury (TBI) has increased.
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Parietal and occipital lobar CMBs counts were higher in PiB(+) ADCI with moderate WMH than PiB(+) ADCI with minimal WMH, whereas PiB(-) patients with SVCI (ie, "pure" SVCI) showed both lobar and deep CMBs.
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We identified 24 relevant studies of 7575 patients, including 2860 with lacunar stroke; 24% had MCI or dementia post stroke.
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These findings support the idea that vascular amyloid burden directly contributes to chronic cerebral ischemia and highlights the possible utility of amyloid imaging as a marker of CAA severity.
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Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia.
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70/100
A single traumatic brain injury is associated with an increased risk of dementia and, in a proportion of patients surviving a year or more from injury, the development of hallmark Alzheimer's disease-like pathologies.
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Cerebrovascular disease has an important role in cognitive decline and dementia.
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40/100
Microinfarctions are present in the aged and injured human brain.
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Microinfarcts are a common clinical feature of the aging brain, particularly in patients with cognitive decline or vascular or Alzheimer's dementia.
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51/100
A growing body of evidence demonstrates an association between vascular risk factors and Alzheimer's disease.
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Recent studies suggest that a complex, distributed neural network underpins semantic cognition.
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These results indicate an association between brain hypoperfusion and the dementia of AD.
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Of 1,212,015 beneficiaries, 11.9 per 1,000 had prevalent and 2.9 new cases of epilepsy.
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The past decade has shed new light on the etiology of Alzheimer's disease (AD), which is the consequence of interactions between numerous lesions.
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Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an alternative mechanism.
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Acceleration in WMH burden, a common indicator of cerebrovascular disease in the elderly, is a pathologic change that emerges early in the presymptomatic phase leading to MCI.
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Aging-associated WMHs evolve significantly over a 4-year period.
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Abnormalities of functional connectivity in the default mode network (DMN) recently have been reported in patients with amnestic mild cognitive impairment (aMCI), Alzheimer's disease (AD) or other psychiatric diseases.
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Subcortical vascular mild cognitive impairment (svMCI) is known to be a prodromal stage of subcortical vascular dementia (SVaD) (1-3) who may also developed to mixed Alzheimer's disease (AD) (4).
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The Framingham Heart Study has enrolled 3 generations of participants, the original cohort (gen 1) enrolled in 1948, the offspring cohort (gen 2) enrolled in 1971 and the third generation enrolled in 2002.
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Stepwise decreases in WM integrity as measured by both DTI and FLAIR were independently associated with stepwise increases in WMH risk, emphasizing that these modalities may provide complementary information for understanding the time course of aging-associated WM degeneration.
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Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD).
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Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries.
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Although epidemiological data associate hypertension with a strong predisposition to develop Alzheimer disease, no mechanistic explanation exists so far.
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This study investigated the role of microglia in remodeling synapses within the developing brain.
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Delirium is a profound, acute confusional state that leads to long-term cognitive decline.
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Increasing evidence suggests a role of atherosclerosis in the pathogenesis of cognitive impairment and dementia.
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Hypertension, a powerful risk factor for stroke and dementia, has damaging effects on the brain and its vessels.
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Our study demonstrated that rTMS improved action naming in subjects with PNFA, possibly due to the modulation of DLPFC pathways and a facilitation effect on lexical retrieval processes.
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A staging system based on this conceptual model of cerebrovascular pathology could enable the neuropathologic quantification of the cerebrovascular burden in dementia.
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According to the vascular depression hypothesis, subclinical cerebrovascular disease can cause depression in older adults.
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IL-6, and, to a lesser degree, CRP levels were associated with WMH severity as well as global markers of brain atrophy.
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Cerebral microbleeds are frequently found in the general elderly population and may reflect underlying vascular disease, but their role in cognitive function is unknown.
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Vascular cognitive impairment is an umbrella term for cognitive dysfunction associated with and presumed to be caused by vascular brain damage.
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Among 91 nondemented subjects completing neuropsychological testing (mean/SD age, 73.4/11.6 years; 44% female; 56% stroke), 39 (42%) had MCI (amnestic multiple domain=10, nonamnestic multiple domain=9, nonamnestic single domain=19, amnestic single domain=1).
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To assess the contribution of hyperammonemia and inflammation to induction of mild cognitive impairment (or MHE).
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Aortic stiffness increases with age and vascular risk factor exposure and is associated with increased risk for structural and functional abnormalities in the brain.
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These preliminary study results show an association between human brain activity of microglia, astrocytes, and IL-6 and delirium in elderly patients and add to the accumulating evidence that inflammatory mechanisms are involved in delirium.
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Chronic traumatic encephalopathy (CTE) has been linked to participation in contact sports such as boxing and American football.
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Granulovacuolar degeneration (GVD) is characterized by the presence of vacuolar cytoplasmic lesions in nerve cells of the medial temporal lobe.
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Various experimental models are used to study brain development and degeneration.
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Baseline DBP and longitudinal increases in DBP were independently associated with a greater WMHV, and the association between DBP and WMHV was greatest among blacks.
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Recent genetic and proteomic studies demonstrate that clusterin/apolipoprotein-J is associated with risk, pathology, and progression of Alzheimer's disease (AD).
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This statement serves as an overall guide for practitioners to gain a better understanding of VCI and dementia, prevention, and treatment.
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Asymptomatic Aβ deposition in older adults is strongly associated with LMH.
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The aim of the study was to compare the long-term efficacy of high versus low frequency repetitive transcranial magnetic stimulation (rTMS), applied bilaterally over the dorsolateral prefrontal cortex (DLPFC), on cognitive function and cortical excitability of patients with Alzheimer's disease (AD).
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Diseases of the central nervous system (CNS) pose a significant health challenge, but despite their diversity, they share many common features and mechanisms.
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75/100
This large GWAS of WMH burden in community-based cohorts of individuals of European descent identifies a novel locus on chromosome 17.
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SVaD without abnormal amyloid imaging was more common than expected.
From across this tag
9 of the 903 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Cholesterol metabolism in aging simultaneously altered in liver and nervous system
- Vascular smooth muscle contraction in hypertension
- Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications
- Post-stroke depression, executive dysfunction and functional outcome
- A neuroradiologist's guide to arterial spin labeling MRI in clinical practice
- Exposure to antipsychotics and risk of stroke: self controlled case series study
- Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study
- Association between the social exposome and vascular brain injury in brain bank donors
- Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?