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Perivascular spaces are associated with atherosclerosis: an insight from the Northern Manhattan Study
Gutierrez J, Rundek T, Ekind MS, Sacco RL, Wright CB.. AJNR. American journal of neuroradiology, 2013-04-04
Topic: Brain proteins, microglia and lab models
Background and purpose Perivascular spaces are potential spaces found between brain blood vessels and surrounding leptomeninges that have been associated with cardiovascular risk factors and dementia, but less is known about their relationship to atherosclerosis. We tested the hypothesis that perivascular spaces are associated with atherosclerosis. Materials and methods Participants from the Northern Manhattan Study who remained stroke-free were invited to participate in an MR imaging substudy. Parenchymal hypointensities of Results The studied sample included 706 participants (mean age, 72.6 ± 8.0 years; 60% women, 61% Hispanic, 68% with hypertension, 19% with diabetes, and 57% with high cholesterol). The perivascular spaces score ranged from 0 to 19 with 52% of the sample having a perivascular spaces score of ≤4. In unadjusted analysis, perivascular spaces were associated with age (β = 0.01 per year, P = Conclusions Perivascular spaces were more frequently found in older participants, in those with hypertension, and in the presence of carotid plaque. These results suggest that mechanisms leading to atherosclerosis might also lead to an increased number of perivascular spaces. These results need confirmation in prospective studies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Gutierrez, J., Rundek, T., Ekind, M. S., Sacco, R. L., & Wright, C. B. (2013). Perivascular spaces are associated with atherosclerosis: an insight from the Northern Manhattan Study. AJNR. American journal of neuroradiology. https://doi.org/10.3174/ajnr.a3498
Vancouver
Gutierrez J, Rundek T, Ekind MS, Sacco RL, Wright CB. Perivascular spaces are associated with atherosclerosis: an insight from the Northern Manhattan Study. AJNR. American journal of neuroradiology. 2013. doi:10.3174/ajnr.a3498. PMID: 23557952.
BibTeX
@article{gutierrez2013-23557952,
author = {Gutierrez, J. and Rundek, T. and Ekind, M. S. and Sacco, R. L. and Wright, C. B.},
title = {{Perivascular spaces are associated with atherosclerosis: an insight from the Northern Manhattan Study}},
journal = {AJNR. American journal of neuroradiology},
year = {2013},
doi = {10.3174/ajnr.a3498},
pmid = {23557952},
url = {https://doi.org/10.3174/ajnr.a3498}
}
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Key findings
- Background and purpose Perivascular spaces are potential spaces found between brain blood vessels and surrounding leptomeninges that have been associated with cardiovascular risk factors and dementia, but less is known about their relationship to atherosclerosis.
- We tested the hypothesis that perivascular spaces are associated with atherosclerosis.
- Parenchymal hypointensities of Results The studied sample included 706 participants (mean age, 72.6 ± 8.0 years; 60% women, 61% Hispanic, 68% with hypertension, 19% with diabetes, and 57% with high cholesterol).
- In unadjusted analysis, perivascular spaces were associated with age (β = 0.01 per year, P = Conclusions Perivascular spaces were more frequently found in older participants, in those with hypertension, and in the presence of carotid plaque.
- These results suggest that mechanisms leading to atherosclerosis might also lead to an increased number of perivascular spaces.
Why it matters
This study found that perivascular spaces were more frequently found in older participants, in those with hypertension, and in the presence of carotid plaque, suggesting mechanisms leading to atherosclerosis might also lead to more perivascular spaces. The authors state these results need confirmation in prospective studies, and no treatment or prevention is tested.
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Study details
- Participants706
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (AJNR. American journal of neuroradiology) |
| Journal's citation record | 2 / 4 | American Journal of Neuroradiology: journal h-index 182 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 706 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 86 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.7 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 2 / 6 | Cited 2.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Clinton B. Wright: h-index 67 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Columbia University: institution h-index 1,824 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23557952) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 46 / 100 | — |
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Read the original
- DOI: 10.3174/ajnr.a3498
- PubMed: 23557952
- Original source →
- Free full text: American Journal of Neuroradiology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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