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63/100

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Disparities

Topic: Brain proteins, microglia and lab models

Background and purpose Elevated blood pressure (BP) is a risk factor for stroke and dementia, but the effect of BP, and change in BP over time, on white matter hyperintensity volume (WMHV) is not fully understood. Few studies have included Hispanics, who are at greater risk of stroke and dementia than non-Hispanic whites. We examined BP in relation to WMHV in a stroke-free cohort. Methods The Northern Manhattan Study includes 1290 stroke-free participants who had brain MRI. We examined baseline systolic and diastolic (DBP) BP, and changes in BP from baseline to MRI, and WMHV. Results There were 1281 participants with brain MRI and 2 BP measurements (mean age, 64 years; SD=8; range, 40 to 94 years). Baseline DBP was associated with greater WMHV (P 5 mm Hg DBP from baseline to MRI had 1.21% greater WMHV relative to those whose BP did not increase (P=0.02). The association between baseline DBP and WMHV was strongest for blacks compared with Hispanics and whites (interaction P=0.04). Conclusions Baseline DBP and longitudinal increases in DBP were independently associated with a greater WMHV, and the association between DBP and WMHV was greatest among blacks.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Marcus, J., Gardener, H., Rundek, T., Elkind, M. S., Sacco, R. L., Decarli, C., et al. (2011). Baseline and longitudinal increases in diastolic blood pressure are associated with greater white matter hyperintensity volume: the northern Manhattan study. Stroke. https://doi.org/10.1161/strokeaha.111.617571

Vancouver

Marcus J, Gardener H, Rundek T, Elkind MS, Sacco RL, Decarli C, et al. Baseline and longitudinal increases in diastolic blood pressure are associated with greater white matter hyperintensity volume: the northern Manhattan study. Stroke. 2011. doi:10.1161/strokeaha.111.617571. PMID: 21836088.

BibTeX

@article{marcus2011-21836088,
  author  = {Marcus, J. and Gardener, H. and Rundek, T. and Elkind, M. S. and Sacco, R. L. and Decarli, C. and Wright, C. B.},
  title   = {{Baseline and longitudinal increases in diastolic blood pressure are associated with greater white matter hyperintensity volume: the northern Manhattan study}},
  journal = {Stroke},
  year    = {2011},
  doi     = {10.1161/strokeaha.111.617571},
  pmid    = {21836088},
  url     = {https://doi.org/10.1161/strokeaha.111.617571}
}

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Key findings

Results There were 1281 participants with brain MRI and 2 BP measurements (mean age, 64 years; SD=8; range, 40 to 94 years).
Baseline DBP was associated with greater WMHV (P 5 mm Hg DBP from baseline to MRI had 1.21% greater WMHV relative to those whose BP did not increase (P=0.02).
The association between baseline DBP and WMHV was strongest for blacks compared with Hispanics and whites (interaction P=0.04).
Conclusions Baseline DBP and longitudinal increases in DBP were independently associated with a greater WMHV, and the association between DBP and WMHV was greatest among blacks.

Why it matters

In this stroke-free cohort, baseline diastolic blood pressure and increases in diastolic blood pressure over time were independently associated with greater white matter hyperintensity volume, with the strongest association among blacks. This is an observational link between blood pressure and a brain imaging measure, not evidence that any treatment prevents or cures Alzheimer's disease.

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Study details

Study designlongitudinal study
Participants1,281
Effect size1.21%
Evidence strengthModerate

How this study scored 63/100

Published in a peer-reviewed journal, and it is a randomised controlled trial.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Stroke)
Journal's citation record	3 / 4	Stroke: journal h-index 455 (OpenAlex, 2026-10-29)
Study design	11 / 12	A randomised controlled trial (from PubMed type “Randomized Controlled Trial”)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2011 — within 20 year(s) of the newest study here
Sample size	3 / 4	1,281 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	4 / 7	Cited 79 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.6 citations a year over 17 year(s) since 2011
Impact for its field and year	2 / 6	Cited 1.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 7 other studies in this library
Still being cited	2 / 4	Cited 15 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Clinton B. Wright: h-index 67 (OpenAlex, whole career)
Institution's track record	1 / 3	University of California, Davis: institution h-index 1,257 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 21836088)
Free to read	0 / 2	Behind a paywall — scores zero
Total	63 / 100	—

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